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Volumn 13, Issue 3, 1999, Pages 359-365

Clinical cross-resistance between the HIV-1 protease inhibitors saquinavir and indinavir and correlations with genotypic mutations

Author keywords

Antiretroviral therapy; Cross resistance; HIV; Indinavir; Protease inhibitors; Resistance mutations; Saquinavir

Indexed keywords

CD4 ANTIGEN; INDINAVIR; LAMIVUDINE; PROTEINASE INHIBITOR; SAQUINAVIR; VIRUS RNA; ZIDOVUDINE;

EID: 0032969551     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199902250-00008     Document Type: Article
Times cited : (49)

References (33)
  • 1
    • 2442723342 scopus 로고    scopus 로고
    • Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine
    • Collier AC, Coombs RW, Schoenfeld DA, et al.: Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med 1996, 334:1011-1017.
    • (1996) N Engl J Med , vol.334 , pp. 1011-1017
    • Collier, A.C.1    Coombs, R.W.2    Schoenfeld, D.A.3
  • 2
    • 0028846165 scopus 로고
    • A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease
    • Danner SA, Carr A, Leonard JM, et al.: A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. N Engl J Med 1995, 333:1528-1533.
    • (1995) N Engl J Med , vol.333 , pp. 1528-1533
    • Danner, S.A.1    Carr, A.2    Leonard, J.M.3
  • 3
    • 0028806725 scopus 로고
    • A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
    • Markowitz M, Saag M, Powderly WG, et al.: A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N Engl J Med 1995, 333:1534-1539.
    • (1995) N Engl J Med , vol.333 , pp. 1534-1539
    • Markowitz, M.1    Saag, M.2    Powderly, W.G.3
  • 4
    • 0030317870 scopus 로고    scopus 로고
    • The effect of high dose saquinavir on viral load and CD4+ T-cell counts in HIV- infected patients
    • Schapiro JM, Winters MA, Stewart F, et al.: The effect of high dose saquinavir on viral load and CD4+ T-cell counts in HIV- infected patients. Ann Intern Med 1996, 124:1039-1050.
    • (1996) Ann Intern Med , vol.124 , pp. 1039-1050
    • Schapiro, J.M.1    Winters, M.A.2    Stewart, F.3
  • 5
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, et al.: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998, 338:853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella F.J., Jr.1    Delaney, K.M.2    Moorman, A.C.3
  • 6
    • 6844240219 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ritonavir in advanced HIV-1 disease
    • The Advanced HIV Disease Ritonavir Study Group
    • Cameron DW, Heath-Chiozzi M, Danner S, et al.: Randomized placebo-controlled trial of ritonavir in advanced HIV-1 disease. The Advanced HIV Disease Ritonavir Study Group. Lancet 1998, 351:543-549.
    • (1998) Lancet , vol.351 , pp. 543-549
    • Cameron, D.W.1    Heath-Chiozzi, M.2    Danner, S.3
  • 7
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior anfiretroviral therapy
    • Gulick RM, Mellors JW, Havlir D, et al.: Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior anfiretroviral therapy. N Engl J Med 1997, 337:734-739.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3
  • 8
    • 0442268112 scopus 로고    scopus 로고
    • Controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
    • AIDS Clinical Trials Group 320 Study Team
    • Hammer SM, Squires KE, Hughes MD, et al.: Controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med 1997, 337:725-733.
    • (1997) N Engl J Med , vol.337 , pp. 725-733
    • Hammer, S.M.1    Squires, K.E.2    Hughes, M.D.3
  • 9
    • 0030730288 scopus 로고    scopus 로고
    • Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure
    • Wong JK, Gunthard HF, Havlir DV, et al.: Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure. Proc Natl Acad Sci USA 1997, 94:12574-12579.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12574-12579
    • Wong, J.K.1    Gunthard, H.F.2    Havlir, D.V.3
  • 10
    • 17344367978 scopus 로고    scopus 로고
    • A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection
    • Markowitz M, Conant M, Hurley A, et al.: A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection. J Infect Dis 1998, 177:1533-1540.
    • (1998) J Infect Dis , vol.177 , pp. 1533-1540
    • Markowitz, M.1    Conant, M.2    Hurley, A.3
  • 11
    • 0029824426 scopus 로고    scopus 로고
    • In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: Mutations, kinetics, and frequencies
    • Jacobsen H, Hanggi M, Ott M, et al.: In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: mutations, kinetics, and frequencies. J Infect Dis 1996, 173:1379-1387.
    • (1996) J Infect Dis , vol.173 , pp. 1379-1387
    • Jacobsen, H.1    Hanggi, M.2    Ott, M.3
  • 12
    • 10344263394 scopus 로고    scopus 로고
    • Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor
    • Condra JH, Holder DJ, Schleif WA, et al.: Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol 1996, 70:8270-8276.
    • (1996) J Virol , vol.70 , pp. 8270-8276
    • Condra, J.H.1    Holder, D.J.2    Schleif, W.A.3
  • 13
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV-1 protease confers resistance to ritonavir
    • Molla A, Korneyeva M, Gao Q, et al.: Ordered accumulation of mutations in HIV-1 protease confers resistance to ritonavir. Nat Med 1996, 2:760-766.
    • (1996) Nat Med , vol.2 , pp. 760-766
    • Molla, A.1    Korneyeva, M.2    Gao, Q.3
  • 14
    • 0032103187 scopus 로고    scopus 로고
    • Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients
    • Shafer RW, Winters MA, Palmer S, Merigan TC: Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. Ann Intern Med 1998, 128:906-911.
    • (1998) Ann Intern Med , vol.128 , pp. 906-911
    • Shafer, R.W.1    Winters, M.A.2    Palmer, S.3    Merigan, T.C.4
  • 15
    • 2642704250 scopus 로고    scopus 로고
    • Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy
    • Gunthard HF, Wong JK, Ignacio CC, et al.: Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. J Virol 1998, 72:2422-2428.
    • (1998) J Virol , vol.72 , pp. 2422-2428
    • Gunthard, H.F.1    Wong, J.K.2    Ignacio, C.C.3
  • 17
    • 17344371054 scopus 로고    scopus 로고
    • 3 (ACTG 175)
    • AIDS Clinical Trials Group Protocol 175 Team
    • 3 (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team. J Infect Dis 1998, 177:617-624.
    • (1998) J Infect Dis , vol.177 , pp. 617-624
    • Lathey, J.L.1    Hughes, M.D.2    Fiscus, S.A.3
  • 18
    • 0344015847 scopus 로고    scopus 로고
    • Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients
    • Fätkenheuer G, Theisen A, Rockstroh J, et al.: Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients. AIDS 1997, 11:F113-F116.
    • (1997) AIDS , vol.11
    • Fätkenheuer, G.1    Theisen, A.2    Rockstroh, J.3
  • 19
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra JH, Schleif WA, Blahy OM, et al.: In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995, 374:569-571.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 20
    • 0030012398 scopus 로고    scopus 로고
    • Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538)
    • Schmit JC, Ruiz L, Clotet B, et al.: Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538). AIDS 1996, 10:995-999.
    • (1996) AIDS , vol.10 , pp. 995-999
    • Schmit, J.C.1    Ruiz, L.2    Clotet, B.3
  • 21
    • 0032568248 scopus 로고    scopus 로고
    • Resistance and cross-resistance with saquinavir and other HIV protease inhibitors: Theory and practice
    • Roberts NA, Craig JC, Sheldon J: Resistance and cross-resistance with saquinavir and other HIV protease inhibitors: theory and practice. AIDS 1998, 12:453-460.
    • (1998) AIDS , vol.12 , pp. 453-460
    • Roberts, N.A.1    Craig, J.C.2    Sheldon, J.3
  • 22
    • 0027431874 scopus 로고
    • Biological variation and quality control of plasma human immunodeficiency virus type 1 RNA quantitation by reverse transcriptase polymerase chain reaction
    • Winters M, Tan LB, Katzenstein DA, Merigan TC: Biological variation and quality control of plasma human immunodeficiency virus type 1 RNA quantitation by reverse transcriptase polymerase chain reaction. J Clin Microbiol 1993, 31:2960-2966.
    • (1993) J Clin Microbiol , vol.31 , pp. 2960-2966
    • Winters, M.1    Tan, L.B.2    Katzenstein, D.A.3    Merigan, T.C.4
  • 23
    • 0028092998 scopus 로고
    • Multicenter evaluation of quantification methods for plasma human immunodeficiency virus type 1 RNA
    • Lin HJ, Myers LE, Yen-Leiberman B, et al.: Multicenter evaluation of quantification methods for plasma human immunodeficiency virus type 1 RNA. J Infect Dis 1994, 170:553-562.
    • (1994) J Infect Dis , vol.170 , pp. 553-562
    • Lin, H.J.1    Myers, L.E.2    Yen-Leiberman, B.3
  • 24
    • 0027503137 scopus 로고
    • Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells
    • Wood R, Dong H, Katzenstein DA, Merigan TC: Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells. J Acquir Immune Defic Syndr 1993, 6:237-240.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 237-240
    • Wood, R.1    Dong, H.2    Katzenstein, D.A.3    Merigan, T.C.4
  • 25
    • 0030978122 scopus 로고    scopus 로고
    • AIDS trials ethics questioned
    • Cohen J: AIDS trials ethics questioned. Science 1997, 276:520-523.
    • (1997) Science , vol.276 , pp. 520-523
    • Cohen, J.1
  • 26
    • 0030948565 scopus 로고    scopus 로고
    • Current problems in the future of antirelroviral drug trials
    • Lange JMA: Current problems in the future of antirelroviral drug trials. Science 1997, 276:548-550.
    • (1997) Science , vol.276 , pp. 548-550
    • Lange, J.M.A.1
  • 27
    • 0028843163 scopus 로고
    • Characterisation of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro31-8959
    • Jacobsen H, Yasargil K, Winslow DL, et al.: Characterisation of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro31-8959. Virology 1995, 206:527-534.
    • (1995) Virology , vol.206 , pp. 527-534
    • Jacobsen, H.1    Yasargil, K.2    Winslow, D.L.3
  • 28
    • 0031949563 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease genotypes and in vitro protease inhibitor susceptibilities of isolates from individuals who were switched to other protease inhibitors after long-term saquinavir treatment
    • Winters MA, Schapiro JM, Lawrence J, Merigan TC: Human immunodeficiency virus type 1 protease genotypes and in vitro protease inhibitor susceptibilities of isolates from individuals who were switched to other protease inhibitors after long-term saquinavir treatment. J Virol 1998, 72:5303-5306.
    • (1998) J Virol , vol.72 , pp. 5303-5306
    • Winters, M.A.1    Schapiro, J.M.2    Lawrence, J.3    Merigan, T.C.4
  • 29
    • 0003247871 scopus 로고    scopus 로고
    • Predictors of antiviral response to saquinavir/ritonavir therapy in a clinical cohort who have failed prior protease inhibitors: A comparison of clinical characteristics, antiretroviral drug history and HIV genotype
    • Lake Maggiore, Italy, June [abstract 54]
    • Zolopa AR, Shafer RW, Warford A, Montoya JG, Katzenstein DA, Merigan TC: Predictors of antiviral response to saquinavir/ritonavir therapy in a clinical cohort who have failed prior protease inhibitors: a comparison of clinical characteristics, antiretroviral drug history and HIV genotype. Second International Workshop on Drug Resistance and Treatment Strategies, Lake Maggiore, Italy, June 1998 [abstract 54].
    • (1998) Second International Workshop on Drug Resistance and Treatment Strategies
    • Zolopa, A.R.1    Shafer, R.W.2    Warford, A.3    Montoya, J.G.4    Katzenstein, D.A.5    Merigan, T.C.6
  • 31
    • 0002100277 scopus 로고    scopus 로고
    • Correlations of virological response with genotype and phenotype of plasma HIV-1 variants in patients treated with nelfinavir in the US expanded access program
    • Lake Maggiore, Italy, Month? [abstract 57]
    • Patick AK, Zhang M, Hertogs K, et al.: Correlations of virological response with genotype and phenotype of plasma HIV-1 variants in patients treated with nelfinavir in the US expanded access program. Second International Workshop on Drug Resistance and Treatment Strategies. Lake Maggiore, Italy, Month? 1998 [abstract 57].
    • (1998) Second International Workshop on Drug Resistance and Treatment Strategies
    • Patick, A.K.1    Zhang, M.2    Hertogs, K.3
  • 32
    • 0007010412 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection in 1998: Updated recommendations of the international AIDS society-USA panel
    • Carpenter CC, Fischl MA, Hammer SM, et al.: Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel. JAMA 1998, 280:78-86.
    • (1998) JAMA , vol.280 , pp. 78-86
    • Carpenter, C.C.1    Fischl, M.A.2    Hammer, S.M.3
  • 33
    • 17344390474 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adults with HIV infection: Implications for clinical management
    • International AIDS Society-USA Panel
    • Hirsch MS, Conway B, D'Aquila RT, et al.: Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society-USA Panel. JAMA 1998, 279:1984-1991.
    • (1998) JAMA , vol.279 , pp. 1984-1991
    • Hirsch, M.S.1    Conway, B.2    D'Aquila, R.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.