Pharmacologic and therapeutic aspects of the developmentally regulated expression of GABA(A) and GABA(B) receptors: Cerebellar granule cells as a model system

Neurochemistry International

Volumn 34, Issue 5, 1999, Pages 373-377

  Schousboe, Arne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Baclofen; Disinhibition; Isoguvacine; THIP

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; GABOXADOL; PROTEIN G; RECEPTOR SUBTYPE;

ANIMAL CELL; CELL CULTURE; CEREBELLUM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SENSITIVITY; GENE EXPRESSION REGULATION; GRANULE CELL; HUMAN; IN VITRO STUDY; MODEL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION;

ANIMALS; CELLS, CULTURED; CEREBELLUM; GABA AGONISTS; GABA ANTAGONISTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MODELS, BIOLOGICAL; NEURONS; RECEPTORS, GABA-A; RECEPTORS, GABA-B;

EID: 0032969496     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00044-3     Document Type: Conference Paper

References (50)

1. Belhage B., Damgaard I., Saederup E., Squires R.F., Schousboe A. High- and low-affinity GABA-receptors in cultured cerebellar granule cells regulate transmitter release by different mechanisms. Neurochem. Int. 19:1991;475-482.
2. Belhage B., Hansen G.H., Elster E., Schousboe A. Effects of γ-aminobutyric acid (GABA) on synaptogenesis and synaptic function. Perspec. Devel. Neurobiol. 5:1998;235-246.
3. Bowery N.G., Hill D.R., Hudsun A.L., Doble A., Middlemiss D.N., Shaw J., Turnbull M.J. ( - )-Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature. 283:1980;92-94.
4. A receptors. J. Neurosci. Res. 50:1997;1053-1062.
5. A receptor subunit expression in the cerebellum. Eur. J. Pharmacol. 352:1998;1-14.
6. Cherubini E., Gaiarsa J.L., Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. TINS. 14:1991;515-519.
7. A receptor-activated current by norepinephrine in cerebellar Purkinje cells. Neuroscience. 51:1993;951-960.
8. +- and kainate-mediated depolarization on survival and functional maturation of GABAergic and glutamatergic neurons in cultures of dissociated mouse cerebellum. Neurochem. Res. 21:1996;267-275.
9. Drejer J., Schousboe A. Selection of a pure cerebellar granule cell culture by kainate treatment. Neurochem. Res. 14:1989;751-754.
10. Drejer J., Larsson O.M., Kvamme E., Svenneby G., Hertz L., Schousboe A. Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivo. Neurochem. Res. 10:1985;49-62.
11. Ebert B., Thompson S.A., Saounatsou K., McKernan R., Krogsgaard-Larsen P., Wafford K.A. Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human γ-aminobutyric acid type A receptors. Mol. Pharmacol. 52:1997;1150-1156.
12. A receptors. FASEB J. 5:1991;2466-2472.
13. B agonists and antagonists in transmitter release and somatic calcium channel currents in cultured neurons. Neuroscience. 38:1990;721-729.
14. Isaacson J.S., Solis J.M., Nicoll R.A. Local and diffuse synaptic actions of GABA in the hippocampus. Neuron. 10:1993;165-175.
15. BR2. Nature. 396:1998;674-679.
16. B receptors in regulation of transmitter release in cerebellar granule neurons. J. Neurosci. 29:1994;646-655.
17. B receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
18. B-receptor subtypes assemble into functional heteromeric complexes. Nature. 396:1998;683-687.
19. A receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects. J. Med. Chem. 37:1994;2489-2505.
20. A receptor phosphorylation: multiple sites, actions and artifacts. TIPS. 12:1991;84-87.
21. Levi G., Gallo V. Glutamate as a putative transmitter in the cerebellum: stimulation by GABA of glutamic acid release from specific pools. J. Neurochem. 37:1981;22-31.
22. A receptor channels. Ann. Rev. Neurosci. 17:1994;569-602.
23. Madtes P.C., Redburn D.A. GABA as a trophic factor during development. Life Sci. 33:1983;979-984.
24. Madtes P.C., Redburn D.A. Synaptic interactions in the GABA system during postnatal development in retina. Brain Res. Bull. 101:1983;741-745.
25. Meier E., Schousboe A. Differences between GABA receptor binding to membranes from cerebellum during postnatal development and from cultured cerebellar granule cells. Dev. Neurosci. 5:1982;546-553.
26. Meier E., Drejer J., Schousboe A. Trophic actions of GABA on the development of physiologically active GABA receptors. Mandel P., DeFeudis F.V. CNS-Receptors from Molecular Pharmacology to Behavior. 1983;47-58 Raven Press, New York.
27. Meier E., Drejer J., Schousboe A. GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells. J. Neurochem. 43:1984;1737-1744.
28. Meldrum B.S. Update on the mechanism of action of antiepileptic drugs. Epilepsia 37. Suppl. 6:1996;S4-S11.
29. Messer A. The maintenance and identification of mouse cerebellar granule cells in mono layer culture. Brain Res. 130:1977;1-12.
30. Mitchell R. A novel GABA receptor modulates stimulus induced glutamate release from cortico-striatal terminals. Eur. J. Pharmacol. 67:1980;119-122.
31. Mott D.D., Darrell V.L. Facilitation of the induction of long-term potentiation by GABAB receptors. Science. 252:1991;1718-1720.
32. 3H]aspartate from rat hippocampus monitored by intracerebral microdialysis. Neurochem. Res. 14:1989;321-326.
33. Nyitrai G., Szárics É, Kovács I., Kékesi K.A., Juhász G., Kardos J. Effect of CGP 36742 on the extracellular level of neurotransmitter amino acids in the thalamus. Neurochem. Int. 34:1999;391-398.
34. Palay S.L., Chan-Palay V. The Cerebellum - New Vistas. Exp. Brain Res. Suppl. 6:1982;1-620.
35. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature. 397:1999;251-255.
36. Roberts E. Living systems are tonically inhibited, autonomous optimizers, and disinhibition coupled to variability generation is their major organizing principle: Inhibitory command-control at levels of membrane, genome, metabolism, brain, and society. Neurochem. Res. 16:1991;409-421.
37. A receptors and glomerular geometry. Neuron. 20:1998;783-795.
38. A receptor isoforms. Mol. Pharmacol. 49:1996;567-579.
39. Schousboe A., Redburn D.A. Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. J. Neurosci. Res. 41:1995;1-7.
40. Schousboe A., Meier E., Drejer J., Hertz L. Preparation of primary cultures of mouse (rat) cerebellar granule cells. Shahar A., De Vellis J., Vernadakis A., Haber B. A Dissection and Tissue Culture Manual of the Nervous System. 1989;203-206 Alan R. Liss, New York.
41. ++ homeostasis and transmitter release in cerebellar granule neurons. In: Tanaka, L., Bowery, N.G. (Eds.), GABA: Receptors, Transporters and Metabolism. Birkhauser Publ. Comp., Basel, pp. 103-113.
42. A receptors. Neurochem. Int. 34:1999;379-385.
43. A receptors. TIPS. 16:1995;162-168.
44. Travagli R.A., Ulivi M., Wojcik W.J. γ-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx. J. Pharm. Exp. Ther. 258:1991;903-909.
45. Vale C., Damgaard I., Suñol C., Rodríguez-Farré E., Schousboe A. Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABAB receptors. J. Neurosci. Res. 52:1998;286-294.
46. A receptor subtypes. Mol. Pharmacol., 240-244.
47. Wafford, K.A., Bain, C.J., Whiting, P.J., Kemp, J.A., 1993b. A functional comparison of the role of γ subunits in recombinant γ-aminobutyric acid type A/benzodiazepine receptors, Mol. Pharmacol. 437-442.
48. A receptors, and glutamate receptors develop sequentially on embryonic rat spinal cord cells. J. Neurosci. 13:1993;2068-2084.
49. White J.H., Wise A., Main M.J., Green A., Fraser N.J., Disney G.H., Barnes A.A., Emson P., Foord S.M., Marshall F.H. Heterodimerization is required for the formation of a functional GABAB receptor. Nature. 396:1998;679-682.
50. A receptor gene family: new targets for therapeutical intervention. Neurochem. Int. 34:1999;387-390.