Effects of immunoregulatory cytokines on the immunogenic potential of the cellular components of a bilayered living skin equivalent

Tissue Engineering

Volumn 5, Issue 2, 1999, Pages 171-181

  Laning, Joseph C ^a   Deluca, Jennifer E ^a   Hardin Young, Janet ^a  

^a ORGANOGENESIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 6;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KERATINOCYTE; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SKIN FIBROBLAST; T LYMPHOCYTE;

EID: 0032969440     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.1999.5.171     Document Type: Article

References (30)

1. Bilbo, P.R., Nolte, C.J.M., Oleson, M.A., Mason, V.S., and Parenteau, N.L. Skin in complex culture: the transition from "Culture" phenotype to organotypic phenotype. J. Toxicol. Cutan. Ocular Toxicol. 12, 183, 1993.
2. Parenteau, N.L., Sabolinski, M., Prosky, S., et al. Biological and physical factors influencing the successful engraftment of a cultured human skin equivalent. Biotechnol. Bioeng. 52, 3, 1996.
3. Falanga, V., Margolis, D., Alvarez, O., et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group. Arch. Dermatol. 134, 293, 1998.
4. Muhart, M., McFalls, S., Kirsner, R., Kerdel, F., and Eaglstein, W.H. Bioengineered skin. Lancet 350, 1142, 1997.
5. Eaglstein, W., Iriondo, M., and Laszlo, K. A composite skin substitute (Graftskin) for surgical wounds. Dermatol. Surg. 21, 839, 1995.
6. Phipps, R., Roper, R.L., and Stein, S.H. Alternative antigen presentation pathways: accessory cells which down-regulate immune responses. Regional Immunol. 2, 326, 1989.
7. Nickoloff, B.J., and Turka, L.A. Immunological functions of non-professional antigen-presenting cells. Immunol. Today 15, 464, 1994.
8. Rico, M.J., and Streilein, J.W. Comparison of alloimmunogenicity of Langerhans cells and keratinocytes from mouse epidermis. J. Invest. Dermatol. 89, 607, 1987.
9. Bal, V., McIndoe, A., Denton, G., et al. Antigen presentation by keratinocytes induces tolerance in human T cells. Eur. J. Immunol. 20, 1893, 1990.
10. Murray, A.G., Libby, P., and Pober, J.S. Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. J. Immunol. 154, 151, 1995.
11. Nickoloff, B.J., Mitra, R.S., Green, J., et al. Accessory cell function of keratinocytes for superantigens. Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. J. Immunol. 150, 2148, 1993.
12. Unutmaz, D., Pileri, P., and Abrignani, S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180, 1159, 1994.
13. Macatonia, S.E., Hosken, N.A., Litton, M., et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154, 5071, 1995.
14. Yawalker, N., Limat, A., Brand, C.U., and Braathen, L.R. Constitutive expression of both subunits in interleukin-12 in human keratinocytes. J. Invest. Dermatol. 106, 80, 1996.
15. Kubin, M., Kamoun, M., and Trinchieri, G. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180, 211, 1994.
16. Dalrymple, S.A., Lucian, L.A., Slattery, R., et al. Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect. Immunol. 63, 2262, 1995.
17. Dinarello, C.A. Biologic basis for interleukin-1 in disease. Blood 87, 2095, 1996.
18. Bianchi, R., Grohmann, U., Belladonna, M.L., et al. IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells. J. Immunol. 157, 1589, 1996.
19. Wilkins, L.M., Watson, S.R., Prosky, S.J., Meunier, S.F., and Parenteau, N.L. Development of a bilayered living skin construct for clinical applications. Biotechnol. Bioeng. 43, 747, 1994.
20. 2, but not IL-10. Cell. Immunol. 175, 16, 1997.
21. Becker, D., and Knop, J. Epidermal cell-derived cytokines and delayed-type hypersensitivity. In: Luger, T.A., and Schwarz, T., eds. Epidermal Growth Factors and Cytokines. New York: Marcel Dekker, 1994, pp. 365-374.
22. Hughes, C.C., and Pober, J.S. Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1. J. Immunol. 150, 3148, 1993.
23. Marini, M., Soloperto, M., Mezzetti, M., Fasoli, A., and Mattoli, S. Interleukin-1 binds specific receptors on human bronchial epithelial cells and upregulates granulocyte/macrophage colony-stimulating factor synthesis and release. Am. J. Respir. Cell Mol. Biol. 4, 519, 1991.
24. Maruo, S., Toyo-oka, K., Oh-hora, M., et al. IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones. J. Immunol. 156, 1748, 1996.
25. Niederwieser, D., Aubock, J., Troppmair, J., et al. IFN-mediated induction of MHC antigen expression on human keratinocytes and its influence on in vitro alloimmune responses. J. Immunol. 140, 2556, 1988.
26. Flynn, J.L., Goldstein, M.M., Triebold, K.J., Sypek, J., Wolf, S., and Bloom, B.R. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155, 2515, 1995.
27. Fallarino, F., Uyttenhove, C., Boon, T., and Gajewski, T.F. Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J. Immunol. 156, 1095, 1996.
28. Coughlin, C.M., Wysocka, M., Kurzawa, H.L., Lee, W.M., Trinchieri, G., and Eck, S.L. B7-1 and interleukin 12 synergistically induce effective antitumor immunity. Cancer Res. 55, 4980, 1995.
29. Blotta, M.H., Marshall, J.D., DeKruyff, R.H., and Umetsu, D.T. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J. Immunol. 156, 3133, 1996.
30. McLellan, A.D., Sorg, R.V., Williams, L.A., and Hart, D.N. Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand-dependent pathway. Eur J Immunol. 26, 1204, 1996.