Monoclonal autoantibodies from patients with autoimmune diseases: Synovial fluid B lymphocytes of a patient with rheumatoid arthritis produced an IgGλ antibody recognizing J-sequences of Igκ chains in a conformation-dependent way

Immunobiology

Volumn 200, Issue 2, 1999, Pages 205-214

  Von Landenberg, Philipp ^a,b   Rzepka, Rita ^a   Melchers, Inga ^a,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Klin und Poliklin fur Inn Med I   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ADULT; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; PHAGE DISPLAY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SEQUENCE HOMOLOGY; SYNOVIAL FLUID;

EID: 0032969274     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0171-2985(99)80070-9     Document Type: Article

References (41)

1. NATVIG, J. B. I. RANDEN, K. M. THOMPSON, O. FØRRE, and E. MUNTHE. 1989. The B cell system in the rheumatoid inflammation: new insights into the pathogenesis of rheumatoid arthritis using synovial B cell hybridoma clones. Springer Semin Ummunopathol 11: 301.
2. MELCHERS, I., H. H. PETER, and H. EIBEL. 1995. The T and B Cell Repertoire of Patients with Rheumatoid Arthritis. Scand. J. Rheumatol. 154: 1951.
3. PANAYI, G. S. 1993. The immunopathogenesis of rheumatoid arthritis. Br. J. Rheumatol. 32: 4.
4. KLARESKOG, L., J. RÖNNELID, and G. HOLM. 1993. Immunopathogenesis and immunotherapy in rheumatoid arthritis: an area in transition. J. Intern. Med. 32: 4.
5. + B cells specific for mycobacterial heat shock protein 60 or human type II collagen in synovial fluid and tissue. Arthritis & Rheumatism 40: 1409.
6. MUNTHE, E., and J. B. NATVIG. 1972. Immunoglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells. Clin. Exp. Immunol. 12: 55.
7. RANDEN, I., O. J. MELLBYE, O. FØRRE, and J. NATVIG. 1995. The identification of germinal centers and follicular dendritic cell networks in rheumatoid synovial tissue. Scand. J. Immunol. 41: 481.
8. SCHRÖDER, A. E., A. GREINER, C. SEYFERT, and C. BEREK. 1996. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Nat. Acad. Sci. U. S. A. 93: 221.
9. YOUINOU, P. Y., J. W. MORROW, A. W. LETTIN, P. M. LYDYARD, and I. M. ROITT. 1984. Specificity of plasma cells in the rheumatoid synovium. I. Immunoglobulin class of antiglobulin-producing cells. Scand. J. Immunol. 20: 307.
10. SMILEY, J. D., C. SACHS, and M. ZIFF. 1968. In vitro synthesis of immunoglobulin by rheumatoid synovial membrane. J. Clin. Invest. 47: 624.
11. MELLBYE, O. J., F. VARTDAL, and J. H. DOBLOUG. 1984. Subclasses of IgG produced in the rheumatoid synovium. Rheumatol. Int. 4: 49.
12. JASIN, H. E. 1985. Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis & Rheumatism 28: 241.
13. ROWLEY, M. J., D. J. WILLIAMSON, and I. R. MACKAY. 1987. Evidence for local synthesis of antibodies to denatured collagen in the synovium in rheumatoid arthritis. Arthritis & Rheumatism 30: 1420.
14. WINCHESTER, R. J., V. AGNELLO, and A. G. KUNKEL. 1970 Gammaglobulin complexes in synovial fluids of patients with rheumatoid arthritis: partial characterization and relationship to lowered complement levels. Clin. Exp. Immunol. 6: 689.
15. KRENN, V., H. P. VOLLMERS, P. VON LANDENBERG, B. SCHMAUSSER, M. RUPP, A. ROGGENKAMP, and H. K. MÜLLER-HERMELINK. 1996. Immortalized B-lymphocytes from rheumatoid synovial tissue show specificity for bacterial HSP60. Virchows Archiv 427: 511.
16. DEVLIN, J. J., L. C. PANGANIBAN, and P. E. DEVLIN. 1990. Random Peptide Libraries: A Source of Specific Protein Binding Molecules. Science 249: 404.
17. DYBWAD, A., B. BOGEN, J. B. NATVIG, O. FØRRE, and M. SIOUD. 1995. Peptide phage libraries can be an efficient tool for identifying antibody ligands for polyclonal antisera. Clin. Exp. Immunol. 102: 438.
18. ZHONG, G., J. D. BERRY, and S. CHOUKRI. 1997. Mapping epitopes of neutralizing monoclonal antibodies using phage random peptide libraries. J. Ind. Microbiol. Biotechnol. 19: 71.
19. DYBWAD, A., O. FØRRE, J. B. NATVIG, and M. SIOUD. 1995. Structural characterization of peptides that bind synovial fluid antibodies from RA patients: a novel strategy for identification of disease-related epitopes using a random peptide library. Clin. Immunol. Immunopathol. 75: 45.
20. YAO, Z. J., M. C. KAO, and C. CHUNG. 1995. Epitope identification by polyclonal antibody from phage-displayed random peptide library. J. Protein Chemistry 14: 161.
21. ARNETT, F. C. S. M. EDWORTHY, D. A. BLOCH, D. J. MCSHANE, J. F. FRIES, N. S. COOPER, L. A. HEALEY, S. R. KAPLAN, M. H. LIANG, and H. S. LUTHRA. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis & Rheumatism 31: 315.
22. GRUNOW, R., S. JAHN, T. PORSTMANN, S. T. KIESSIG, H. STEINKELLNER, F. STEINDL, D. MATTANOVICH, L. GÜRTLER, F. DEINHARDT, H. KATINGER, and R. VON BAEHR. 1988. The high efficiency human B cell immortalizing heteromyeloma CB-F7. J. Immunol. Meth. 106: 257.
23. LITTLEFIELD, J. W. 1964. Selection of hybrids from matings of fibroblasts in vitro and their presumed recombinants. Science 145: 709.
24. ZIMMERMANN, U., G. KLÖCK, P. GESSNER, D. W. SAMMONS, and G. A. NEIL. 1992. Microscale production of hybridomas by hypoosmolar electrofusion. Hum. Antibod. Hybridomas 3: 14.
25. VOLLMERS, H. P., P. VON LANDENBERG, J. DÄMMRICH, K. STULLE, E. WOZNIAK, C. RINGDÖRFER, H. K. MÜLLER-HERMELINK, B. HERRMANN, and U. ZIMMERMANN. 1993. Electro-Immortalization of B-Lymphocytes isolated from stomach carcinoma biopsy material. Hybridoma 12: 221.
26. SCHLEDZ, M., A. HOHLBAUM, H. H. PETER, U. RUDOLPHI, and I. MELCHERS. 1992. Specificity of monoclonal rheumatoid factors derived from patients with rheumatoid arthritis. Immunobiology 186: 93.
27. MENGE, T., R. HUMMES, M. SCHLEDZ, U. LANGENBERG, H. H. PETER, and I. MELCHERS. 1995. Functional characterization of human monoclonal antibodies with specificities related to rheumatoid arthritis. Immunobiology 194: 145.
28. RUDOLPHI, U., A. HOHLBAUM, B. LANG, H. H. PETER, and I. MELCHERS. 1993. The B cell repertoire of patients with rheumatoid arthritis. I. Frequencies and specificities of peripheral blood cells reacting with human IgG, human collagens, a mycobacterial heat shock protein and other antigens. Clin. Exp. Immunology 36: 660.
29. LOWE, J., P. BIRD, D. HARDIE, R. JEFFERIS, and N. R. LING. 1982. Monoclonal antibodies (McAbs) determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity. Immunology 47: 329.
30. GODING, J. W. 1998. Monoclonal Antibodies: principles and practice. 3rd ed. Academic Press, Harcourt Brace and Co. London.
31. PEARSON, W. R., and D. J. LIPMAN. 1988. Improved tools for biological sequence comparison. PNAS 85: 2444.
32. ALTSCHUL, S. F., W. GISH, W. MILLER, E. W. MYERS, and D. J. LIPMAN. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403.
33. WINKLER, T. H., H. FEHR, and J. R. KALDEN. 1992. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 22: 1719.
34. + B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur. J. of Immunol. 23: 3272.
35. PRATT, L. F., L. RASSENTI, J. LARRICK, B. ROBBINS, P. M. BANKS, and T. J. KIPPS. 1989. Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation. J. Immunology 143: 699.
36. GIUDICELLY, V., D. CHAUME, J. BODMER, W. MÜLLER, C. BUSIN, S. MARSH, R. BOUTROP, L. MARC, A. MALIK, and M. P. PEFRANC. 1997. IMGT, the international ImMunoGeneTics database. Nucleic Acids Research 25: 206.
37. HAMLYN, P. H., M. J. GAIT, and C. MILSTEIN. 1981. Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing. Nucleic Acids Res. 9: 4485.
38. KLEIN, R., R. JAENICHEN, and H. G. ZACHAU. 1993. Expressed human immunoglobulin κ genes and their hypermutation. Eur. J. Immunol. 23: 3248.
39. TRUJILLO, P. E., and M. MANNIK. 1992. IgG is bound by antigen-antibody bonds and some IgG and albumin are bound by intermolecular disulfide bonds to cartilage in rheumatoid arthritis and osteoarthritis. Rheumatol. Int. 11: 225.
40. DARST, S. A., C. R. ROBERTSON, and J. A. BERZOFSKY. 1988. Adsorption of the protein antigen myoglobin affects the binding of conformation-specific monoclonal antibodies. Biophysical Journal 53: 533.
41. COLMAN, P. M., W. G. LAVER, J. N. VARGHESE, A. T. BAKER, P. A. TULLOCH, G. M. AIR, and R. G. WEBSTER. 1987. Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature 326: 358.