Effect of 2,3-butanedione monoxime on force of contraction and protein phosphorylation in bovine smooth muscle

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 359, Issue 6, 1999, Pages 484-492

  Waurick, R ^a   Knapp, J ^a   Van Aken, H ^a   Boknik P ^a   Neumann, J ^a   Schmitz, W ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

2,3 Butanedione monoxime; Cantharidin; Phosphorylation; Protein phosphatase; Smooth muscle; Vasoregulation

Indexed keywords

CANTHARIDIN; DIACETYL OXIME; ENZYME ACTIVATOR; MYOSIN LIGHT CHAIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; POTASSIUM CHLORIDE;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DEPOLARIZATION; MUSCLE FORCE; NONHUMAN; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE CONTRACTION; VASCULAR RING;

ANIMALS; AUTORADIOGRAPHY; CANTHARIDIN; CATTLE; CELLS, CULTURED; CORONARY VESSELS; DIACETYL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; IMMUNOHISTOCHEMISTRY; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOSIN LIGHT CHAINS; PHOSPHORYLATION;

EID: 0032969145     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005380     Document Type: Article

References (32)

1. Alessi D, MacDougall LK, Sola MM, Ikebe M, Cohen P (1992) The control of protein phosphatase-1 by targeting subunits. Eur J Biochem 210:1023-1035
2. 2+ sensitizer EMD 53998 antagonizes the effects of 2,3-butanedione monoxime on skinned cardiac muscle fibers. Eur J Pharmacol 296:285-289
3. Cohen P (1989) The structure and regulation of protein phosphatases. Annu Rev Biochem 58:453-508
4. Dobrowsky RT, Kamibayshi C, Mumby MC, Hannun YA (1993) Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem 268:15523-15530
5. 5. Erdödi F, Ito M, Hartshorne DJ (1996) Myosin light chain phosphatase. In: Biochemistry of smooth muscle contraction. Academic Press, pp 131-142
6. 2+ release by 2,3-butanedione monoxime in crustacean muscle. Pflügers Arch 424:39-44
7. Haase H, Morano I (1996) Alternative splicing of smooth muscle myosin heavy chains and its functional consequences. J Cell Biochem 60:521-528
8. Honkanen RE (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases type 1 and 2A. FEBS Lett 330:283-286
9. Horowitz A, Clement-Chomienne O, Walsh MP, Tao T, Katsuyama H, Morgan KG (1996) Effects of calponin on force generation by single smooth muscle cells. Am J Physiol 270: H1858-H1863
10. Hunter T (1995) Protein kinases and phosphatases: the ying and yang of protein phosphorylation and signaling. Cell 80: 225-236
11. Kamm KE, Stull JT (1985) The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol 25:593-620
12. Knapp J, Bokník P, Linck B, Lüss H, Müller FU, Nacke P, Neumann J, Vahlensieck U, Schmitz W (1997) The effect of protein phosphatases inhibitor cantharidin on ß-adrenoceptor-mediated vasorelaxation. Br J Pharmacol 120:421-428
13. Knapp J, Bokník P, Huke S, Lüss H, Müller FU, Müller T, Nacke P, Schmitz W, Vahlensieck U, Neumann J (1998) The mechanism of action of cantharidin in smooth muscle. Br J Pharmacol 123: 911-919
14. Miller-Hance WC, Kamm KE (1991) Force-velocity relation and myosin light chain phosphorylation in bovine coronary arterial smooth muscle. Circ Res 69:1207-1214
15. Morano M, Zacharzowski U, Maier M, Lange PE, Alexi-Meskishvili V, Haase H, Morano I (1997) Regulation of human heart contractility by essential myosin light chain isoforms. J Clin Invest 98:467-473
16. Mügge A, Harrison DG (1991) L-arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels 28:354-357
17. Mulieri LA, Alpert NR (1994) Differential effects of 2,3-butanedione monoxime (BDM) on activation and contraction. Biophys J 45:47A
18. Neumann J, Bokník P, Herzig S, Schmitz W, Scholz H, Gupta RC, Watanabe AM (1993) Evidence for physiological functions of protein phosphatases in the heart. Evaluation with okadaic acid. Am J Physiol 265:H257-H266
19. Neumann J, Bokník P, Herzig S, Schmitz W, Scholz H, Wiechen K, Zimmermann N (1994) Biochemical and electrophysiological mechanisms of the inotropic effects of calyculin A, a protein phosphatase inhibitor. J Pharmacol Exp Ther 271: 535-541
20. Neumann J, Herzig S, Bokník P, Apel M, Kaspareit G, Schmitz W, Scholz H, Tepel M, Zimmermann M (1995) On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor. J Pharmacol Exp Ther 274:530-539
21. Obara K, Szymanski PT, Tao T, Paul RJ (1996) Effects of calponin on isometric force and shortening velocity in permeabilized Taenia coli smooth muscle. Am J Physiol 270:C481-C487
22. 22. Otun H, Gillespie JI, Greenwell JR, Dunlop W (1993) The actions of caffeine and 2,3-butanedione monoxime on calcium transients in human vascular smooth muscle. Exp Physiol 78:255-258
23. Packer CS, Kagan ML, Kagan JF, Robertson SA, Stephans NL (1988) The effect of 2,3-butanedione monoxime (BDM) on smooth muscle mechanical properties. Pflügers Arch 412:659-664
24. Shenolikar S, Nairn AC (1991) Protein phosphatases: recent progress. In: Greengard P, Robinson GA (eds) Advances in second messenger and phosphoprotein research. Raven, New York, pp 1-121
25. Somlyo AP, Somlyo AV (1994) Signal transduction and regulation in smooth muscle. Nature 372:231-236
26. Tachibana K, Sheuer PJ, Tsukitani Y, Kikuchi H, VanEugen E, Clardy J, Schmitz FJ (1981) Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria. J Am Chem Soc 103:2469-2471
27. Warren TB, Butler TM, Siegman MI, Mooers SU (1985) Effects of 2,3-butanedione monoxime (BDM) on force production and myosin light chain phosphorylation (MYLCP) in mammalian smooth and skeletal muscle. Biophys J 47:295A
28. Watanabe M (1993) Effects of 2,3-butanedione monoxime on smooth-muscle contraction of guinea-pig portal vein. Pflügers Arch 425:462-468
29. Wera S, Hemmings BA (1995) Serine/threonine protein phosphatases. Biochem J 311:17-29
30. Wiggens JR, Reiser J, Fitzpatrick DF, Bergey JL (1980) Inotropic actions of diacetyl monoxime in cat ventricular muscle. J Pharmacol Exp Ther 212:217-224
31. 2+ currents, and action of potentials of rats. Am J Hypertens 8:1232-1240
32. Zimmermann N, Bokník P, Gams E, Gsell S, Jones LR, Maas R, Neumann J, Scholz H (1996) Mechanisms of the contractile effects of 2,3-butanedione monoxime in the mammalian heart. Naunyn-Schmiedeberg's Arch Pharmacol 354:431-436