Portal hyperglutamatemia after dietary supplementation with monosodium glutamate in pigs

Digestion

Volumn 60, Issue 4, 1999, Pages 349-357

  Blachier, François ^a   Guihot Joubrel, Gwénaële ^a   Vaugelade, Pierre ^a   Le Boucher, Jacques ^b   Bernard, Françoise ^a   Duée, Pierre Henri ^a   Cynober, Luc ^b  

^a CEMAGREF   (France)

^b HÔPITAL SAINT ANTOINE   (France)

Author keywords

Amino acid metabolism; Intestine; Monosodium glutamate; Pigs

Indexed keywords

ASPARTIC ACID; GLUTAMATE SODIUM; GLUTAMIC ACID; GLUTAMINE; GLYCINE; SODIUM CHLORIDE;

ADAPTATION; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMINOACIDEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; INTESTINE CELL; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; TRANSAMINATION;

ALANINE; ANIMALS; ASPARTIC ACID; DIETARY SUPPLEMENTS; FOOD ADDITIVES; GLUTAMIC ACID; GLUTAMINE; INTESTINAL ABSORPTION; MALE; PORTAL VEIN; POSTPRANDIAL PERIOD; SODIUM GLUTAMATE; SWINE;

EID: 0032968989     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007682     Document Type: Article

References (34)

1. Giacometti T: Free and bound glutamate in natural products; in Filer LJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds): Glutamic Acid: Advances in Biochemistry and Physiology. New York, Raven Press, 1979, pp 25-34.
2. Olney JW: Excitoxic amino acids: Research applications and safety implications; in Filer LJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds): Glutamic Acid: Advances in Biochemistry and Physiology. New York, Raven Press, 1979, pp 287-319.
3. Kerr GR, Wu-Lee M, El-Lozy M, McGandy R, Stare FJ: Food-symptomatology questionnaires: Risks of demand - bias questions and population - biased surveys; in Filer LJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ (eds): Glutamic Acid: Advances in Biochemistry and Physiology. New York, Raven Press, 1979, pp 375-387.
4. Bogdanov MB, Tjurmina OA, Wurtman RJ: Consumption of a high dietary dose of monosodium glutamate fails to affect extracellular glutamate levels in the hypothalamic arcuate nucleus of adult rats. Brain Res 1996;736:76-81.
5. Matthews DE, Campbell RG: Splanchnic bed utilization of glutamine and glutamic acid in humans. Am J Physiol 1993;264:E848-E854.
6. Meister A: Glutamine metabolism in mammalian tissues; in Häussinger D, Sies S (eds): Enzymology of Glutamine. Berlin, Springer, 1984, pp 9-15.
7. Dillon JC: L'acide glutamique. Cah Nutr Diet 1991;26:157-162.
8. Windmueller HG, Spaeth AE: Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 1974;249:5070-5079.
9. Windmueller HG, Spaeth AE: Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Arch Biochem Biophys 1975;171:662-672.
10. Watford M, Lund P, Krebs HA: Isolation and metabolic characteristics of rat and chicken enterocytes. Biochem J 1979;178:589-596.
11. Watford M: Glutamine metabolism in rat small intestine: Synthesis of three-carbon products in isolated enterocytes. Biochim Biophys Acta 1994;1200:73-78.
12. Blachier F, Darcy-Vrillon B, Sener A, Duée PH, Malaisse WJ: Arginine metabolism in rat enterocytes. Biochim Biophys Acta 1991;1092: 304-310.
13. Dugan MER, Knabe DA, Wu G: The induction of citrulline synthesis from glutamine in enterocytes of weaned pigs is not due primarily to age or change in the diet. J Nutr 1995;125: 2388-2393.
14. Henslee JG, Jones ME: Ornithine synthesis from glutamate in rat small intestinal mucosa. Arch Biochem Biophys 1982;219:186-197.
15. Murphy JM, Murch SJ, Ball RO: Proline is synthesized from glutamate during intragastric infusion but not during intravenous infusion in neonatal piglets. J Nutr 1996;126:878-886.
16. Porteous JW: Glutamate, glutamine, aspartate, asparagine, glucose and ketone-body metabolism in chick intestinal brush-border cells. Biochem J 1980;188:619-632.
17. Reeds PJ, Burrin DG, Stoll B, Jahoor F, Wykes L, Henry J, Frazer ME: Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets. Am J Physiol 1997;273: E408-E415.
18. Uchiyama C, Mori M, Tatibana M: Subcellular localization and properties of N-acetylglutamate synthase in rat small intestinal mucosa. J Biochem 1981;89:1777-1786.
19. Battezzati A, Brillon DJ, Matthews DE: Oxidation of glutamic acid by the splanchnic bed in humans. Am J Physiol 1995;269:E269-E276.
20. 15N] glutamic acid. Clin Sci 1988;75:499-502.
21. Reeds PJ, Burrin DG, Jahoor F, Wykes L, Henry J, Frazer EM: Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract in infant pigs. Am J Physiol 1996;270:E413-E418.
22. Darcy-Vrillon B, Morel MT, Cherbuy C, Bernard F, Posho L, Blachier F, Meslin JC, Duée PH: Metabolic characteristics of pig colonocytes after adaptation to a high fiber diet. J Nutr 1993;123:234-243.
23. Rérat A, Chayvialle JA, Kandé J, Vaissade P, Vaugelade P, Bourrier T: Metabolic and hormonal effects of test meals with various protein contents in pigs. Can J Physiol Pharmacol 1985;63:1547-1559.
24. Blachier F, M'Rabet-Touil H, Posho L, Darcy-Vrillon B, Duée PH: Intestinal arginine metabolism during development. Evidence for de novo synthesis of L-arginine in newborn pig enterocytes. Eur J Biochem 1993;216:109-117.
25. Bergmeyer HU: Methods of Enzymatic Analysis, ed 3. New York, Academic Press, 1974, vol 1-4.
26. Blachier F, Mignon A, Soubrane O: Polyamines inhibit lipopolysaccharide-induced nitric oxide synthase activity in rat liver cytosol. Nitric Oxide Biol Chem 1997;1:268-272.
27. M'Rabet-Touil H, Blachier F, Hellio N, Robert V, Cherbuy C, Darcy-Vrillon B, Duée PH: Transglutaminase activity in enterocytes isolated from pig jejunum. Mol Cell Biochem 1995;146:49-54.
28. Vaugelade P, Posho L, Darcy-Vrillon B, Bernard F, Morel MT, Duée PH: Intestinal oxygen uptake and glucose metabolism during nutrient absorption in the pig. Proc Soc Exp Biol Med 1994;207:309-316.
29. Häussinger D: Nitrogen metabolism in liver: Structural and functional organization and physiological relevance. Biochem J 1990;267: 281-290.
30. Fafournoux P, Remezy C, Demigne C: Fluxes and membrane transport of amino acids in rat liver under different protein diets. Am J Physiol 1990;259:E614-E625.
31. Stegink LD, Filer LJ, Baker GL: Effects of carbohydrate on plasma and erythrocyte glutamate levels in humans ingesting large doses of monosodium L-glutamate in water. Am J Clin Nutr 1983;37:961-968.
32. Stegink LD, Filler LJ, Baker GL, Bell EF: Effect of sucrose ingestion on plasma glutamate concentrations in humans administered monosodium L-glutamate. Am J Clin Nutr 1986;43: 510-515.
33. Cynober L: Metabolic interaction between ornithine and α-ketoglutarate as a basis for the action of ornithine α-ketoglutarate. Clin Nutr 1993;12:54-56.
34. Prior RL, Gross KL: Dietary arginine deficiency and gut ammonium infusion alter flux of urea cycle intermediates across the portal-drained viscera of pigs. J Nutr 1995;125:251-263.