The management of variceal bleeding: Past, present and future

Mount Sinai Journal of Medicine

Volumn 66, Issue 1, 1999, Pages 1-13

  Wolf, David C ^a  

^a WESTCHESTER MEDICAL CENTER   (United States)

Author keywords

Endoscopic variceal ligation; Gastrointestinal bleeding; Octreotide; Portal hypertension; Review; Sclerotherapy; Shunt surgery; TIPS; Variceal bleeding; Varices

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; NITRATE; OCTREOTIDE; SOMATOSTATIN; TERLIPRESSIN; VASOPRESSIN;

ARTICLE; BALLOON; CARDIOTOXICITY; CLINICAL TRIAL; DECOMPRESSION SURGERY; DRUG EFFICACY; DRUG MECHANISM; EMERGENCY TREATMENT; ENDOSCOPIC SCLEROTHERAPY; ENDOSCOPIC SURGERY; ESOPHAGUS DISEASE; ESOPHAGUS VARICES BLEEDING; FLUID THERAPY; GASTROINTESTINAL ENDOSCOPY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER TRANSPLANTATION; ORAL DRUG ADMINISTRATION; PORTAL HYPERTENSION; PORTOCAVAL SHUNT; PORTOSYSTEMIC ANASTOMOSIS; PROPHYLAXIS; RESUSCITATION; SPLENORENAL SHUNT; SUBCUTANEOUS DRUG ADMINISTRATION; VEIN LIGATION;

ACUTE DISEASE; ALGORITHMS; ESOPHAGEAL AND GASTRIC VARICES; GASTROINTESTINAL HEMORRHAGE; HUMANS; HYPERTENSION, PORTAL;

EID: 0032968964     PISSN: 00272507     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (96)

1. Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: Pathophysiology and clinical consequences. Hepatology 1994; 20:1359-1363.
2. Viallet A, Marleau D, Huet M, et al. Hemodynamic evaluation of patients with intrahepatic portal hypertension. Gastroenterology 1975; 69:1297-1300.
3. Garcia-Tsao G, Groszmann RJ, Fisher RL. et al. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 1985; 5:419-424.
4. de Franchis R and the North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med 1988; 319:983-989.
5. Rigau J, Bosch J, Bordas, JM, et al. Endoscopic measurement of variceal pressure in cirrhosis: Correlation with portal pressure and variceal hemorrhage. Gastroenterology 1989; 96:873-880.
6. Bosch J, Garcia-Pagan JC, Feu F, Rodes J. Portal hypertension: Clinical pathobiology. In: Arias IM, Boyer JL, Fausto N. et al., editors. The liver: Biology and pathobiology, 3rd ed. New York: Raven Press. Ltd.; 1994. pp. 1343-1355.
7. D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: A meta-analytic review. Hepatology 1995; 22:332-354.
8. Cales P, Desmorat H, Vinel JP, et al. Incidence of large esophageal varices in patients with cirrhosis: Application to prophylaxis of first bleeding. Gut 1990; 31:1298-1302.
9. D'Amico G, Pasta L, Vizzini GB, et al. Natural history of cirrhosis [abstract]. J Hepatol 1990; 13(Suppl 2):S22.
10. Baker LA, Smith C, Lieberman G. The natural history of esophageal varices. Am J Med 1959; 26:228-237.
11. Pagliaro L, D'Amico G, Sorensen TIA, et al. Prevention of first bleeding in cirrhosis: A meta-analysis of randomized clinical trials of nonsurgical treatment. Ann Intern Med 1992; 117:59-70.
12. Schlichting P, Christensen E, Fauerholdt L, et al. Main causes of death in cirrhosis. Scand J Gastroenterol 1982; 18:881-888.
13. Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology 1981; 80:800-809.
14. Gregory PB and the VA Cooperative Variceal Sclerotherapy Group. Sclerotherapy for actively bleeding esophageal varices in male alcoholics with cirrhosis: Results of a randomized multicenter clinical trial [abstract]. Gastroenterology 1990; 98:A53.
15. deDombal FT, Clarke JR, Clamp SE, et al. Prognostic factors in upper G.I. bleeding. Endoscopy 1986; 18:6-10.
16. Cardin F, Gori G, McCormick PA, et al. A predictive model for very early rebleeding from varices [abstract]. Gut 1990; 31:A1202.
17. Soriano G, Guarner C, Tomas A, et al. Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage. Gastroenterology 1992; 103:1267-1272.
18. Child CG. The liver and portal hypertension. Philadelphia: W.B. Saunders; 1964. p. 50.
19. Pugh RNH, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60:646-649.
20. Schalm SW, van Buuren HR. Prevention of recurrent variceal bleeding: Non-surgical procedures. Clin Gastroenterol 1985; 14:209-232.
21. Pinto HC, Abrantes A, Esteves AV, et al. Long-term prognosis of patients with cirrhosis of the liver and upper gastrointestinal bleeding. Am J Gastroenterol 1989; 84:1239-1243.
22. Graffeo M, Buffoli F, Lanzani G, et al. Survival after endoscopic sclerotherapy for esophageal varices in cirrhotics. Am J Gastroenterol 1994; 89; 1815-1822.
23. Gimson AES, Westaby D, Hegarty J, et al. A randomized trial of vasopressin and vasopressin plus nitroglycerin in the control of acute variceal hemorrhage. Hepatology 1986; 6:410-413.
24. Garcia-Pagan JC, Feu F, Bosch J, Rodes J. Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis: A randomized controlled study. Ann Intern Med 1991; 114:869-873.
25. Merkel C, Marin R, Enzo E, et al. Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Lancet 1996; 348:1677-1681.
26. Villanueva C, Balanzo J, Novella MT, et al. Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal bleeding. N Engl J Med 1996; 334:1624-1629.
27. Angelico M, Carli L, Piat C, et al. Isosorbide-5-mononitrate versus propranolol in the prevention of first bleeding in cirrhotics. Gastroenterology 1993; 104:1460-1465.
28. Kehne JH, Hughes FA, Gompertz ML. Use of surgical Pituitrin in control of esophageal varix bleeding: An experimental study and report of two cases. Surgery 1956; 39:917-925.
29. Shaldon S, Sherlock S. The use of vasopressin ('Pitressin') in the control of bleeding from oesophageal varices. Lancet 1960; 2:222-225.
30. Merrigan TC Jr., Plotkin GR, Davidson CS. Effect of intravenously administered posterior pituitary extract on hemorrhage from bleeding esophageal varices: A controlled evaluation. N Engl J Med 1962; 266:134-135.
31. Chojkier M, Groszmann RJ, Atterbury CE, et al. A controlled comparison of continuous intraarterial and intravenous infusions of vasopressin in hemorrhage from esophageal varices. Gastroenterology 1979; 77:540-546.
32. Rodriguez-Perez F, Groszmann RJ. Pharmacologic treatment of portal hypertension. Gastroenterol Clin North Am 1992; 21:15-40.
33. Burroughs AK. Octreotide in variceal bleeding. Gut 1994; Suppl 3:S23-S27.
34. Burroughs AK, McCormick PA, Hughes MD, et al. Randomized, double-blind, placebo-controlled trial of somatostatin for variceal bleeding: Emergency control and prevention of early variceal rebleeding. Gastroenterology 1990; 99:1388-1395.
35. Shields R, Jenkins SA, Baxter JN, et al. A prospective randomised controlled trial comparing the efficacy of somatostatin with injection sclerotherapy in the control of bleeding oesophageal varices. J Hepatol 1992; 16:128-137.
36. Sung JJY, Chung SCS, Lai C-W, et al. Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Lancet 1993; 342:637-641.
37. Planas R, Quer JC, Boix J, et al. A prospective randomized trial comparing somatostatin and sclerotherapy in the treatment of acute variceal bleeding. Hepatology 1994; 20:370-375.
38. McCormick PA, Chin J, Greenslade L, et al. Cardiovascular effects of octreotide in patients with hepatic cirrhosis. Hepatology 1995; 21:1255-1260.
39. Shields R, Jenkins SA, Baxter JN, et al. Octreotide in the long term management of portal hypertension - Preliminary results of a prospective randomised controlled clinical trial [abstract]. Gastroenterology 1993; 104:A991.
40. Primignani M, Andreoni B, Carpinelli L, et al. Sclerotherapy plus octreotide versus sclerotherapy alone in the prevention of early rebleeding from esophageal varices: A randomized, double-blind, placebo-controlled, multicenter trial. Hepatology 1995; 21:1322-1327.
41. DeLedinghen V, Ripault MP, Silvain C, et al. Subcutaneous octreotide for the prevention of early variceal rebleeding. Hepatology 1996; 23:938-939.
42. Price HL, Cooperman LH, Warden JC. Control of the splanchnic circulation in man: Role of beta-adrenergic receptors. Circ Res 1967;21:333-340.
43. Young HS, Matsui SM, Gregory PB. Endoscopic control of upper gastrointestinal variceal bleeding. In: Yamada T, Alpers DH, Owyang C, et al., editors. Textbook of gastroenterology. 2nd ed. Philadelphia: J.B. Lippincott Co.; 1995. pp. 2969-2991.
44. Crafoord C, Frenckner P. New surgical treatment of varicous veins of the oesophagus. Acta Otolaryngol 1939; 27:422-429.
45. Moersch HJ. Further studies on the treatment of esophageal varices by injection of a sclerosing solution. Ann Otol Rhinol Larnygol 1941; 50:1233-1244.
46. Johnston GW, Rodgers HW. A review of 15 years' experience in the use of sclerotherapy in the control of acute haemorrhage from oesophageal varices. Br J Surg 1973; 60:797-800.
47. Paquet K-J, Oberhammer E. Sclerotherapy of bleeding oesophageal varices by means of endoscopy. Endoscopy 1978; 10:7-12.
48. Terblanche J, Northover JMA, Bornman P, et al. A prospective evaluation of injection sclerotherapy in treatment of acute bleeding from esophageal varices. Surgery 1979; 85:239-245.
49. Williams KDG, Dawson JL. Fibreoptic injection of oesophageal varices. Br Med J 1979; 2:766-767.
50. Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding: A meta-analysis. Ann Intern Med 1995; 123:280-287.
51. Hashizume M, Kitano S, Koyangi N, et al. Endoscopic injection sclerotherapy for 1,000 patients with esophageal varices: A nine-year prospective study. Hepatology 1992; 15:69-75.
52. Westaby D, MacDougall BRD, Williams R. Improved survival following injection sclerotherapy for esophageal varices: Final analysis of a controlled trial. Hepatology 1985; 5:827-830.
53. Paquet K-J, Kalk J-F, Koussouris P. Immediate endoscopic sclerosis of bleeding esophageal varices: A prospective evaluation over five years. Surg Endosc 1988; 2:18-23.
54. Baillie J, Yudelman P. Complications of endoscopic sclerotherapy of esophageal varices. Endoscopy 1992; 24:284-291.
55. Viggiano TR, Gostout CJ. Portal hypertensive intestinal vasculopathy: A review of the clinical, endoscopic, and histopathologic features. Am J Gastroenterol 1992; 87:944-953.
56. Schuman BM, Beckman JW, Tedesco FJ, et al. Complications of endoscopic injection sclerotherapy: A review. Am J Gastroenterol 1987; 82:823-830.
57. Stiegmann GV, Goff JS. Endoscopic esophageal varix ligation: preliminary clinical experience. Gastrointest Endosc 1988; 34:113-117.
58. Marks RD, Arnold MD, Baron TH. Gross and microscopic findings in the human esophagus after esophageal variceal band ligation: A postmortem analysis. Am J Gastroenterol 1993; 88:272-274.
59. Wong T, Pereira S, McNair A, Harrison P. A prospective study of Speedband versus Steigmann-Goff in endoscopic ligation of esophageal varices [abstract]. Gastroenterology 1997; 112:A1416.
60. Stiegmann GV, Goff JS, Michaletz-Onody PA, et al. Endoscopic sclerotherapy as compared with endoscopic ligation for bleeding esophageal varices. N Engl J Med 1992; 326:1527-1532.
61. Sauerbruch T. Prophylaxis of first variceal bleeding: Where does the truth lie? Endoscopy 1994; 26:748-749.
62. Chen CY, Chen, CY, Chang TT. Prophylactic endoscopic variceal ligation (EVL) for esophageal varices [abstract]. Gastroenterology 1997; 112:A1240.
63. Binmoeller KF, Soehendra N. Nonsurgical treatment of variceal bleeding: New modalities. Am J Gastroenterol 1995; 90:1923-1931.
64. Hachisu T, Yamada H, Satoh S-I, Kouzu T. Endoscopic clipping with a new rotatable clip-device and a long clip. Digestive Endoscopy 1996; 8:127-133.
65. Koutsomanis D. Endoscopic clipping versus endolooping for bleeding esophageal varices [abstract]. Gastroenterology 1997; 112.A1308.
66. Yoshida T, Hayashi N, Suzumi N, et al. Endoscopic ligation of gastric varices using a detachable snare. Endoscopy 1994; 26:502-505.
67. Avgerinos A, Nevens F, Raptis S, and the ABOVE Study Group. Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: The European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial. Lancet 1997; 350:1495-1499.
68. Akriviadis E, Korula S, Gupta S, et al. Frequent endoscopic variceal sclerotherapy increases the risk of complications. Dig Dis Sci 1989; 34:1068-1074.
69. Sengstaken RW, Blakemore AH. Balloon tamponage for the control of hemorrhage from esophageal varices. Ann Surg 1950; 131:781-789.
70. Whipple AO. The problem of portal hypertension in relation to the hepatosplenopathies. Ann Surg 1945; 122:449-475.
71. Blakemore AH, Lord JW. The technic of using vitellium tubes in establishing portacaval shunts for portal hypertension. Ann Surg 1945; 122:476-489.
72. Cello JP, Grendell JH, Crass RA, et al. Endoscopic sclerotherapy versus portacaval shunt in patients with severe cirrhosis and acute variceal hemorrhage: Long-term follow-up. N Engl J Med 1987; 316:11-15.
73. Grace ND, Conn HO, Resnick RH, et al. Distal splenorenal vs. portal-systemic shunts after hemorrhage from varices: A randomized controlled trial. Hepatology 1988; 8:1475-1481.
74. Orloff MJ, Bell RH Jr, Orloff MS, et al. Prospective randomized trial of emergency portacaval shunt and emergency medical therapy in unselected cirrhotic patients with bleeding varices. Hepatology 1994; 20:863-872.
75. Henderson JM, Grace ND. A perspective on emergency portacaval shunt. Hepatology 1994; 20:1090-1091.
76. Warren WD, Zeppa R, Fomon J. Selective trans-splenic decompression of gastroesophageal varices by distal splenorenal shunt. Ann Surg 1967; 166:437-455.
77. Henderson JM, Kutner MH, Millikan WJ Jr, et al. Endoscopic variceal sclerosis compared with distal splenorenal shunt to prevent recurrent variceal bleeding in cirrhosis: A prospective, randomized trial. Ann Int Med 1990; 112:262-269.
78. Rosch J, Hanafee WN, Snow H. Transjugular portal venography and radiologic portacaval shunt: An experimental study. Radiology 1969; 92:1112-1114.
79. Colapinto RF, Stronell RD, Gildiner M, et al. Formation of intrahepatic portosystemic shunts using a balloon dilatation catheter: Preliminary clinical experience. Am J Roentgenol 1983; 140:709-714.
80. Palmaz J, Garcia F, Sibbitt RR. et al. Expandable intrahepatic portacaval shunt stents in dogs with chronic portal hypertension. Am J Roentgenol 1986; 147:1251-1254.
81. Richter GM, Noeldge G, Palmaz JC, Roessle M. The transjugular intrahepatic portosystemic stent-shunt (TIPSS): Results of a pilot study. Cardiovasc Intervent Radiol 1990; 13:200-207.
82. Shiffman ML, Jeffers L, Hoofnagle JH, Tralka TS. The role of transjugular intrahepatic portosystemic shunt for treatment of portal hypertension and its complications: A conference sponsored by the National Digestive Diseases Advisory Board. Hepatology 1995; 22:1591-1597.
83. Ring EJ, Lake JR, Roberts JP. et al. Using transjugular intrahepatic portosystemic shunts to control variceal bleeding before liver transplantation. Ann Intern Med 1992; 116:304-309.
84. Ochs A, Rossle M, Haag K, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for refractory ascites. N Engl J Med 1995; 332:1192-1197.
85. Crenshaw WB, Gordon FD, McEniff NJ, et al. Severe ascites: Efficacy of the transjugular intrahepatic portosystemic shunt in treatment. Radiology 1996; 200:185-192.
86. Rozenblit G, DelGuercio LRM, Savino JA, et al. Transmesenteric-transfemoral method of intrahepatic portosystemic shunt placement with minilaparotomy. J Vasc Interv Radiol 1996; 7:499-506.
87. Haskal ZJ, Pentecost MJ, Soulen MC, et al. Transjugular intrahepatic portosystemic shunt stenosis and revision: Early and midterm results. Am J Roentgenol 1994; 163:439-444.
88. LaBerge JM, Somberg KA, Lake JR, et al. Two-year outcome following transjugular intrahepatic portosystemic shunt for variceal bleeding: Results in 90 patients. Gastroenterology 1995; 108:1143-1151.
89. Cello JP, Ring EJ, Olcott EW, et al. Endoscopic sclerotherapy compared with percutaneous transjugular intrahepatic portosystemic shunt after initial sclerotherapy in patients with acute variceal hemorrhage: A randomized, controlled trial. Ann Intern Med 1997; 126:858-865.
90. Sanyal AJ, Freedman AM, Luketic VA, et al. Transjugular intrahepatic portosystemic shunts compared with endoscopic sclerotherapy for the prevention of recurrent variceal hemorrhage: A randomized, controlled trial. Ann Intern Med 1997; 126:849-857.
91. Sugiura M, Futagawa S. Esophageal transaction with paraesophagogastric devascularization (the Sugiura procedure) in the treatment of esophageal varices. World J Surg 1984;8:673.
92. Wexler MJ, Stein BL. Nonshunting operations for variceal hemorrhage. Surg Clin North Am 1990; 70:425-448.
93. McCormick PA, Kaye GL, Greenslade L, et al. Esophageal transection as a salvage procedure after failure of injection sclerotherapy. Hepatology 1992; 15:403-406.
94. Jalan R, John TG, Redhead DN, et al. A comparative study of emergency transjugular intrahepatic portosystemic stentshunt and esophageal transection in the management of uncontrolled variceal hemorrhage. Am J Gastroenterol 1995; 90:1932-1937.
95. Ewaga H, Keeffe EB, Dort J, et al. Liver transplantation for uncontrollable variceal bleeding. Am J Gastroenterol 1994; 89:1823-1826.
96. Saxon RR, Timmermans HA, Uchida BT, et al. Stem-grafts for revision of TIPS stenoses and occlusions: A clinical pilot study. J Vasc Interv Radiol 1997; 8:539-548.