Isolation and structure elucidation of two new flavonoid glycosides from the infusion of Maytenus aquifolium leaves. Evaluation of the antiulcer activity of the infusion

Journal of Agricultural and Food Chemistry

Volumn 47, Issue 2, 1999, Pages 403-406

  Vilegas, Wagner ^a   Sanommiya, Miriam ^a   Rastrelli, Luca ^b   Pizza, Cosimo ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

1D and 2D NMR; Antiulcer activity; Celastraceae; Espinheira santa; Flavonoid glycosides; Infusion; Maytenus aquifolium Martius

Indexed keywords

ANTIULCER AGENT; BIOFLAVONOID; DRUG DERIVATIVE; FLAVONOID GLYCOSIDE; KAEMPFEROL 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-6) O [BETA DEXTRO GLUCOPYRANOSYL (1-3) O ALPHA LEVO RHAMNOPYRANOSYL (1-2)] O BETA DEXTRO GALACTOPYRANOSIDE; KAEMPFEROL 3-O-RHAMNOPYRANOSYL-1-6-O-(GLUCOPYRANOSYL-1-3-O-RHAMNOPYRANOSYL-1-2)-O- GALACTOPYRANOSIDE; MEDICINAL PLANT; OLIGOSACCHARIDE; QUERCETIN; QUERCETIN 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-6) O [BETA DEXTRO GLUCOPYRANOSYL (1-3) O ALPHA LEVO RHAMNOPYRANOSYL (1-2)] O BETA DEXTRO GALACTOPYRANOSIDE; QUERCETIN 3-O-RHAMNOPYRANOSYL-1-6-O-(GLUCOPYRANOSYL-1-3-O-RHAMNOPYRANOSYL-1-2)-O- GALACTOPYRANOSIDE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAZIL; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; EXTRACTION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFUSION; ISOLATION AND PURIFICATION; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; MENTAL STRESS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PATHOPHYSIOLOGY; PLANT LEAF; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; STOMACH ULCER; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTI-ULCER AGENTS; BRAZIL; FLAVONOIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KAEMPFEROLS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; OLIGOSACCHARIDES; PLANT LEAVES; PLANTS, MEDICINAL; QUERCETIN; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET; STOMACH ULCER; STRESS, PSYCHOLOGICAL;

ANIMALIA; CELASTRACEAE; MAYTENUS; MAYTENUS AQUIFOLIUM;

EID: 0032967586     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf980114i     Document Type: Article

References (17)

1. Agrawal, P. K. In Carbon-13 NMR of Flavonoids; Elsevier: Amsterdam, The Netherlands, 1989.
2. Basile, A. C.; Sertie, J. A. A.; Oshiro, T. T.; Caly, K. D. V.; Panizza, S. Topical Anti-inflammatory Activity and Toxicity of Cordia verbenacea. Fitoterapia 1989, 60, 260-263.
3. Bernal, H. Y.; Correa, Q. J. E. In Especies Vegetales Promisorias de los Paises del Convenio Andrés Bello; SECAB: Bogota, Colombia, 1990; Vol. 4.
4. Bodenhausen, E.; Ruben, D. J. Unexpected Cross Peaks in Two-Dimensional Homonuclear-Relayed Coherence-Transfer Spectroscopy of a Peptide. J. Magn. Reson. 1986, 69, 185-186.
5. Carlini, E. A. Estudos de acao anti-ulcera gastrica de plantas brasileiras: Maytenus ilicifolia (Espinheira Santa) e outras; CEME/AFIF: Brasilia, 1988.
6. Finger, A.; Engerhardt, U. H.; Wray, V. Flavonol Triglycosides Containing Galactose in Tea. Phytochemistry 1991, 30, 2057-2060.
7. Gonzalez, G. A. Componentes Mayoritarios del Maytenus aquifolium y Sintesis Parcial del Acido 3-oxo-20-hidroxi-lup-28-oico. Rev. Latinoam. Quim. 1986, 17, 51-53.
8. Harborne, J. B. In The Flavonoids-Advances in Research since 1980; Chapman and Hall: London, 1988.
9. Hertog, M. G. L.; Hollman, P. C. H.; Katan, M. B. Content of Potentially Anticarcinogenic Flavonoids of 28 Vegetables and 9 Fruits Commonly Consumed in The Netherlands. J. Agric. Food Chem. 1992, 40, 2379-2383.
10. Hertog, M. G. L.; Feskens, E. J. M.; Hollman, P. C. H.; Kuhn, M. B.; Kromhout, D. Dietary Anti-oxidant Flavonoids and the Risk of Coronary Heart Disease: the Zupthen Elderly Study. Lancet 1993, 342, 1007.
11. Homans, S. W. In Program in NMR Spectroscopy; Pergamon Press: Oxford, U.K., 1990; pp 55-81.
12. Martin, G. E.; Crouch, R. C. Inverse Detected Two-Dimensional NMR Methods: Application in Natural Products Chemistry. J. Nat. Prod. 1991, 54, 1-70.
13. Sanommiya, M.; Vilegas, W.; Rastrelli, L.; Pizza, C. Flavonoid Glycoside from Maytenus aquifolium. Phytochemistry 1997, in press.
14. Shirota, O.; Monta, H.; Takeya, K; Itokawa, H. Sesquiterpene Pyridine Alkaloids from Maytenus ilicifolia. Heterocycles 1994, 38, 383-389.
15. Takagi, K.; Kasuya, Y.; Watanabe, K. Studies on the Drugs for Peptic Ulcer. A Reable Method for Producing Stress Ulcer in Rats. Chem. Pharm. Bull. 1964, 12, 465-472.
16. Vilegas, J. H. Y.; Lancas, F. M.; Cervi, A. C. HRGC Analysis of Adulteration of "espinheira-santa", a Brazilian Medicinal Plant. Phytother. Res. 1994, 8, 241-244.
17. Vinson, J. A.; Dabbagh, Y. A.; Serry, M. M.; Jang, J. Plant Flavonoids Specially Tea Flavonols, are Powerful Antioxidants using an in vitro Oxidation Model for Heart Disease. J. Agric. Food Chem. 1995, 43, 2800-2802.