Upstream elements bestow T-cell and haemopoietic progenitor-specific activity on the granzyme B promoter

Gene

Volumn 234, Issue 1, 1999, Pages 101-107

  Johnson, Barbra A ^a   John, Victoria A ^a   Henschler, Reinhard ^b   Hampson, Ian N ^a   Heyworth, Clare M ^a   Babichuk, Charolyn K ^c   Bleackley, R Chris ^c   Dexter, T Michael ^a   Cross, Michael A ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Apoptosis; Chromatin; Cytotoxic T cell; Gene regulation

Indexed keywords

GRANZYME B;

ARTICLE; COSMID; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE MAPPING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RESTRICTION MAPPING; SOUTHERN BLOTTING; STEM CELL; T LYMPHOCYTE;

ANIMALS; CELL LINE; CLONING, MOLECULAR; COSMIDS; DEOXYRIBONUCLEASE I; GRANZYMES; HEMATOPOIETIC STEM CELLS; MALE; MICE; PROMOTER REGIONS (GENETICS); SERINE ENDOPEPTIDASES; T-LYMPHOCYTES;

EID: 0032967204     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(99)00173-0     Document Type: Article

References (22)

1. Babichuk C.K., Duggan B.L., Bleackley R.C. In vivo regulation of murine granzyme B gene transcription in activated primary T cells. J. Biol. Chem. 271:1996;16485-16493.
2. Baum C., Forster P., Hegewisch-Becker S., Harbers K. An optimized electroporation protocol applicable to a wide range of cell lines. Biotechniques. 17:1994;1058-1062.
3. + peripheral blood progenitor cells mobilized by chemotherapy and granulocyte colony-stimulating factor. Blood. 86:1995;3500-3506.
4. Church G.M., Gilbert W. Genomic sequencing. Proc. Natl. Acad. Sci. USA. 81:1984;1991-1995.
5. Crosby J.L., Bleackley R.C., Nadeau J.H. A complex of serine protease genes expressed preferentially in cytotoxic T-lymphocytes is closely linked to the T-cell receptor alpha- and delta-chain genes on mouse chromosome 14. Genomics. 6:1990;252-259.
6. Fregeau C.J., Bleackley R.C. Transcription of two cytotoxic cell protease genes is under the control of different regulatory elements. Nucleic Acids Res. 19:1991;5583-5590.
7. Graubert T.A., DiPersio J.F., Russell J.H., Ley T.J. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J. Clin. Invest. 100:1997;904-911.
8. Haddad P., Wargnier A., Bourge J.F., Sasportes M., Paul P. A promoter element of the human serine esterase granzyme B gene controls specific transcription in activated T cells. Eur. J. Immunol. 23:1993;625-629.
9. Hampson I.N., Cross M.A., Heyworth C.M., Fairbairn L., Spooncer E., Cowling G.J., Dexter T.M. Expression and down regulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines. Blood. 80:1992;3097-3105.
10. Hampson I.N., Hampson L., Pinkoski M., Cross M., Heyworth C.M., Bleackley R.C., Atkinson E., Dexter T.M. Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells. Blood. 89:1997;108-118.
11. Hanson R.D., Grisolano J.L., Ley T.J. Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription. Blood. 82:1993;2749-2757.
12. Hanson R.D., Hohn P.A., Popescu N.C., Ley T.J. A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus. Proc. Natl. Acad. Sci. USA. 87:1990;960-963.
13. Hanson R.D., Sclar G.M., Kanagawa O., Ley T.J. The 5′-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice. J. Biol. Chem. 266:1991;24433-24438.
14. Heusel J.W., Wesselschmidt R.L., Shresta S., Russell J.H., Ley T.J. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76:1994;977-987.
15. Kan O., Whetton A.D., Heyworth C.M. Development of haemopoietic cells in liquid culture. Testa N.G., Molineux G. Haemopoiesis: A Practical Approach. 1993;123-138 IRL Press, Oxford.
16. Karasuyama H., Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:1988;97-104.
17. Lobe C.G., Shaw J., Fregeau C., Duggan B., Meier M., Brewer A., Upton C., McFadden G., Patient R.K., Paetkau V., Bleackley R.C. Transcriptional regulation of two cytotoxic T lymphocyte-specific serine protease genes. Nucleic Acids Res. 17:1989;5765-5779.
18. Lobe C.G., Upton C., Duggan B., Ehrman N., Letellier M., Bell J., McFadden G., Bleackley R.C. Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII. Biochemistry. 27:1988;6941-6946.
19. Pham C.T., MacIvor D.M., Hug B.A., Heusel J.W., Ley T.J. Long-range disruption of gene expression by a selectable marker cassette. Proc. Natl. Acad. Sci. USA. 93:1996;13090-13095.
20. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY.
21. Wargnier A., Legros-Maida S., Bosselut R., Bourge J.F., Lafaurie C., Ghysdael J., Sasportes M., Pascale P. Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation. Proc. Natl. Acad. Sci. USA. 92:1995;6930-6934.
22. Williams G.T., Smith C.A., Spooncer E., Dexter T.M., Taylor D.R. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature. 343:1990;76-79.