L-thyroxine prevents the bone-conserving effect of HRT in postmenopausal women with subclinical hypothyroidism

Gynecological Endocrinology

Volumn 13, Issue 3, 1999, Pages 196-201

  Pines, A ^a,b,c,e   Dotan, I ^a   Tabori, U ^a   Villa, Y ^a   Mijatovic, V ^d   Levo, Y ^a   Ayalon, D ^a,b,c  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b Ramat Marpe Hospital   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Ichilov Medical Center   (Israel)

Author keywords

Bone mineral density; HRT; L thyroxine; Subclinical hypothyroidism

Indexed keywords

LEVOTHYROXINE; THYROTROPIN;

ADULT; AGED; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HORMONE SUBSTITUTION; HUMAN; HUMAN CELL; HYPOTHYROIDISM; LUMBAR SPINE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; THYROTROPIN BLOOD LEVEL;

EID: 0032966987     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.3109/09513599909167555     Document Type: Article

References (21)

1. Ross DS. Subclinical hypothyroidism. In Braverman LE, Vitiger RD, eds. Werner and Ingbars' The Thyroid, 6th edn. Philadelphia: JB Lippincot, 1991:1256-62
2. Kabadi UM. 'Subclinical hypothyroidism'; natural course of the syndrome during a prolonged followup study. Arch Intern Med 1993;153:957-61
3. Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol 1977;7:481-93
4. Tunbridge WM, Brewis M, French JM, et al. Natural history of autoimmune thyroiditis. Br Med J (Clin Res) 1981;282:258-62
5. Helfand M, Crapo LM. Screening for thyroid disease. Ann Intern Med 1990;112:840-9
6. Cooper DS, Halpern R, Wood LC, et al. L-thyroxine therapy in subclinical hypothyroidism. A double-blind placebo-controlled trial. Ann Intern Med 1984;101:18-24
7. Ridgway EC, Cooper DS, Walker H, et al. Peripheral responses to thyroid hormone before and after L-thyroxine therapy in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 1981;53:1238-42
8. Arem R, Patsch W. Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Effect of levothyroxine therapy. Arch Intern Med 1990; 150:2097-100
9. Neer RM. Osteoporosis. In DeGroot LJ, ed. Endocrinology, 3rd edn. Philadelphia: WB Saunders, 1995:1245
10. Paul TL, Kerrigan J, Kelly AM, et al. Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women. JAMA 1988;259:3137-41
11. Ross DS, Neer RM, Ridgway EC, et al. Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. Am J Med 82:1167-70
12. Schneider MD, Barrett-Connor EL, Morton DJ. Thyroid hormone use and bone mineral density in elderly women. JAMA 1994;271:1245-9
13. Lindsay R, Hart DM, Forrest C, et al. Prevention of spinal osteoporosis in oophorectomised women. Lancet 1980;ii:1151-4
14. Ettinger B, Genant HK, Cann CE. Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 1985;102:319-24
15. Eastell R. Treatment of postmenopausal osteoporosis. N Engl J Med 1998;338:736-46
16. Heaney RP. Estrogen-calcium interactions in the postmenopause: a quantitative description. Bone Mineral 1990;11:67-84
17. Baran DT, Braverman LE. Thyroid hormone and bone mass. J Clin Endocrinol Metab 1991;72:1182-3
18. Franklyn JA, Betteridge J, Daykin J, et al. Long-term thyroxine treatment and bone mineral density. Lancet 1992;340:9-13
19. Ross DS. Bone density is not reduced during the short-term administration of levothyroxine to postmenopausal women with subclinical hypothyroidism: a randomized, prospective study. Am J Med 1993;95:385-8
20. Fujiyama K, Kiriyama T, Ito M, et al. Suppressive doses of thyroxine do not accelerate age-related bone loss in late postmenopausal women. Thyroid 1995;5:13-17
21. Arata N, Momotani N, Maruyama H, et al. Bone mineral density after surgical treatment for Graves' disease. Thyroid 1997;7:547-54