Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model: Interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 2, 1999, Pages 442-453

  Gu, Lingjie ^a   Johnson, Michael W ^a   Lusis, Aldons J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibodies; Antinuclear; Genes; HDL; Linkage analysis; Lupus erythematosus; Systemic

Indexed keywords

AUTOANTIBODY; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL MODEL; ANTIBODY DETECTION; ARTICLE; ATHEROGENESIS; AUTOIMMUNE DISEASE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 15; CHROMOSOME 19; CHROMOSOME 5; CHROMOSOME 8; CORONARY ARTERY DISEASE; GENE LOCUS; GENE MAPPING; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0032966978     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.2.442     Document Type: Article

References (56)

1. Lusis AJ, Ivandic B. Lipid metabolism. In: Emery and Rimoin's Principles and Practice of Medical Genetics. 3rd ed. New York, NY: Churchill Livingstone; 1996:1945-1976.
2. Martin MJ, Hulley SB, Browner WS, Kuller LH, Wentworth D. Serum cholesterol, blood pressure, and mortality implications from a cohort of 361,662 men. Lancet. 1986;2:933-936.
3. Gordon DJ, Probstfeld JL, Neaton JD, Castelli WP, Knoke JD, Jacobs DR, Bangdiwala S, Tyroler HA. High density lipoprotein cholesterol and cardiovascular disease: four prospective American studies. Circulation. 1989;79:8-15.
4. Navab M, Imes SS, Hama SY, Hough GP, Ross LA, Bork RW, Valente AJ, Berliner JA, Drinkwater DC, LaksH, Fogelman AM. Monocyte transmigration induced by modification of low density lipoprotein in coculture of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J Clin Invest. 1991;88:2039-2046.
5. Sing CF, Moll PP. The genetic architecture of cholesterol metabolism. Ann Rev Genet. 1990;24:171-187.
6. Goldbourt U, Neufeld HN. Genetic aspects of atherosclerosis. Arteriosclerosis. 1986;6:357-377.
7. Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity. 1994;1:219-229.
8. Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB, Rodrigues N, Lathrop M, Pressey A, Delarato NH, Peterson LB, Wicker LS. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 1991; 351:542-547.
9. Warden CH, Fisler JS, Pace MJ, Svenson KL, Lusis AJ. Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model. J Clin Invest. 1993;92:773-779.
10. Purcell-Huynh DA, Weinreb A, Castellani LW, Mehrabian M, Doolittle MH, Lusis AJ. Genetic factors in lipoprotein metabolism. J Clin Invest. 1995;96:1845-1858.
11. Machleder D, Ivandic B, Welch C, Castellani L, Reue K, Lusis AJ. Complex genetic control of HDL levels in mice in response to an atherogenic diet: coordinate regulation of HDL levels and bile acid metabolism. J Clin Invest. 1997;99:1406-1419.
12. Qiao JH, Xie PZ, Fishbein MC, Kreuzer J, Drake TA, Demer LL, Lusis AJ. Pathology of atheromatous lesions in inbred and genetically engineered mice: genetic determination of arterial calcification. Arterioscler Thromb. 1994;14:1480-1497.
13. Yamaguchi Y, Kitagawa S, Imaizumi N, Kunitomo M, Fujiwara M. Effects of cholesterol loading on autoimmune MKL-lpr/lpr mice: susceptibility to hypercholesterolemia and aortic cholesterol deposition. Japan J Pharmacol. 1993;61:291-298.
14. Qiao JH, Castellani LW, Fishbein MC, Lusis AJ. Immune-complex-mediated vasculitis increases coronary artery lipid accumulation in autoimmune-prone MRL mice. Arterioscler Thromb. 1993;13: 932-943.
15. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 1992;356:314-317.
16. Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, Matsuzawa A, Rochelle JM, Seldin MF. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med. 1992;176:1645-1656.
17. Johnson H, Nived O, Sturfelt G. Outcome in systemic lupus erythematosus: a prospective study of patients from a defined population. Medicine. 1989;68:141-150.
18. Haider YS, Roberts WC. Coronary artery disease in systemic lupus erythematosus: quantification of degree of narrowing in 22 necropsy patients (21 woman) aged 16 to 37 years. Am J Med. 1981;70: 775-781.
19. Petri M, Spence D, Bone LR, Hochberg MC. Coronary artery disease risk factors in the Johns Hopkins Lupus Cohort: prevalence, recognition by patients, and preventive practices. Medicine. 1992;71: 291-302.
20. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68:231-240.
21. Stewart-Phillips JL, Lough J. Pathology of atherosclerosis in cholesterol-fed, susceptible mice. Atherosclerosis. 1991;90:211-218.
22. Paigen B, Morrow A, Brandon C, Mitchell D, Holmes PA. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis. 1985;57:65-73.
23. Mehrabian M., Qiao JH, Doolittle M, Ruddle D, Laughton C, Lusis AJ. Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice. Arterioscler Thromb. 1993;13:1-10.
24. Weisbart RH, Noritake DT, Wong AL, Chan G, Kacena A, Colburn KK. A conserved anti-DNA antibody idiotype associated with nephritis in murine and human systemic lupus eryhtematosus. J Immunol. 1990;144:2653-2658.
25. Love JM, Knight Am, McAleer MA, Todd JA. Towards construction of a high-resolution map of the mouse genome using PCR-analyzed microsatellites. Nucleic Acids Res. 1990;18:4123-4130.
26. Dietrich WF, Katz H, Lincoln SE, Shin HS, Friedman SJ, Dracopoli NC, Lander ES. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 1992;131:423-447.
27. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newberg L. MAPMAKER: an interaction computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1987;1:174-181.
28. Manly KF. A Macintosh program for storage and analysis of experimental genetic mapping data. Mamm Genome. 1993;4:303-313.
29. Paterson AH, Damon S, Hewitt JD, Zamir D, Rabinowitch HD, Lincoln SE, Lander ES, Tanksley SD. Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics. 1991;127:181-197.
30. Lander ES, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241-247.
31. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics. 1994;138:963-971.
32. Lander ES, Schork NJ. Genetic dissection of complex traits. Science. 1994;265:2037-2048.
33. Gu L, Lusis AJ. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol. 1998;161:6999-7006.
34. Welch CL, Xia Y-R, Schechter I, Farese R, Mehrabian M. Mehdizadeh S, Warden CH, Lusis AJ. Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996;37:1406-1421.
35. Yui MA, Muralidharan K, Moreno-Altamirano B, Perrin G, Chestnut K, Wakeland EK. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome. 1996;7: 331-334.
36. Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome. 1996;1996:335-339.
37. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-B1 as a high density lipoprotein receptor. Science. 1996;271:518-520.
38. Welch CL, Xia YR, Gu L, Machleder D, Mehrabian M, Wen PZ, Webb N, de Villiers WJ, van der Westhuyzen A, Lusis AJ. Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs for plasma lipoprotein levels. Mamm Genome. 1997;8:942-944.
39. Acton SL, Scherer PE, Lodish HF, Krieger M. Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem. 1994;269:21003-21009.
40. Rigotti A, Acton SL, Krieger M. The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids. J Biol Chem. 1995;270:16221-16224.
41. Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature. 1997;387:414-417.
42. Hoffmann GF, Charpentier C, Mayatepek E, Mancini J, Leichsenring M, Gibson KM, Divry P, Hrebicek M, Lehnert W, Sartor K, Trefz FK, Rating D, Bremer HJ. Clinical and biochemical phenotype in 11 patients with mevalonic aciduria. Pediatrics. 1993;91:915-921.
43. Hubner C, Hoffmann GF, Charpentier C, Gibson KM, Finckh B, Puhl H, Lehr HA, Kohlschutter A. Decreased plasma ubiquinone-10 concentration in patients with mevalonate kinase deficiency. Pediatr Res. 1993;34:129-133.
44. Mehlum A, Staels B, Duverger N, Tailleux A, Castro G, Fievet C, Luc G, Fruchart JC, Olivecrona G, Skretting G, Auwerx J, Prydz H. Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile. Eur J Biochem. 1995;230: 567-575.
45. Vaisman BL, Klein HG, Rouis M, Bérard AM, Kindt MR, Talley GD, Meyn SM, Hoyt RF, Marcovina SM, Albers JJ, Hoeg JM, Brewer HB, Santamarina-Fojo S. Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. J Biol Chem. 1995;270:12269-12275.
46. Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci U S A. 1993;90:11603-11607.
47. Motoyoshi K, Takaku F. Serum cholesterol-lowering activity of human monocytic colony-stimulating factor. Lancet. 1989;2:326-327. Letter.
48. de Villiers WJ, Fraser IP, Hughes DA, Doyle AG, Gordon S. Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function. J Exp Med. 1994;180:705-709.
49. Venkatraman JT, Chandrasekar B, Kim JD, Fernandes G. Genotype effects on the antioxidant enzymes activity and mRNA expression in liver and kidney tissues of autoimmune-prone MRL/MpJ-lpr/lpr mice. Biochim Biophys Acta. 1994;1213:167-175.
50. Mizutani H, Kurata Y, Kosugi S, Shiraga M, Kashiwagi H, Tomiyama Y, Kanakura Y, Good RA, Matsuzawa Y. Monoclonal anticardiolipin autoantibodies established from the (New Zealand White X BXSB) F1 mouse model of antiphospholipid syndrome cross-react with oxidized low-density lipoprotein. Arthritis Rheum. 1995;38:1382-1388.
51. Hörkkö S, Miller E, Dudl E, Reaven P, Curtiss LK, Zvaifler NJ, Terkeltaub R, Pierangeli SS, Branch DW, Palinski W, Witztum JL. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids: recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein. J Clin Invest. 1996;98: 815-825.
52. Bowry VW, Stanley KK, Stocker R. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proc Natl Acad Sci U S A. 1992;89: 10316-10320.
53. Lembertas AV, Perusse L, Chagnon YC, Fisler JS, Warden CH, Purcell-Huynh DA, Dionne FT, Gagnon J, Nadeaull A, Lusis AJ, Bouchard C. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest. 1997;100: 1240-1247.
54. Ettinger WH, Goldberg AP, Applebaum-Bowden D, Hazzard WR. Dyslipoproteinaemia in SLE: effects of corticosteroids. Am J Med. 1987;83:503-508.
55. Mouse Genome Database: 1995. Available at http://www.informatics. jax.org.
56. Silver LM, Nadeau JH, editors. Mouse Chromosome Committee reports. Mamm Genome. 1994;5(suppl):S1-S388.