Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: Implications for neuroprotection?

British Journal of Ophthalmology

Volumn 83, Issue 2, 1999, Pages 236-240

  Sharif, N A ^a   Xu, S X ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARCAINE; DECANE; DIZOCILPINE; ELIPRODIL; GLUTAMIC ACID; IFENPRODIL; IONOPHORE; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POLYAMINE; PUTRESCINE; RADIOLIGAND; SPERMIDINE; SPERMINE; TRITIUM;

AFFINITY LABELING; ARTICLE; COMPETITIVE INHIBITION; DRUG BINDING SITE; HUMAN; HUMAN TISSUE; NEUROPROTECTION; PRIORITY JOURNAL; RADIOASSAY; RETINA; SCATCHARD PLOT;

EID: 0032966962     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.83.2.236     Document Type: Article

References (42)

1. Sharif NA. Multiple synaptic receptors for neuroactive amino acid transmitters - new vistas. Int Rev Neurobiol 1985;26:85-150.
2. Collingridge GL, Lester RA. Excitatory amino acid receptors in the vertebrate nervous system. Pharmacol Rev 1989;40:143-210.
3. 2+ permeability in single rat retinal ganglion cells. Neuroscience 1995;67:177-88.
4. Choi DW. Excitotoxic cell death. J Neurobiol 1992;23:1261-76.
5. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1996;330:613-22.
6. Louzada-Junior P, Dias JJ, Santos WF, et al. Glutamate release in experimental ischemia of the retina: an approach using microdialysis. J Neurochem 1992;59:358-63.
7. Lucas DR, Newhouse JP. The toxic effects of sodium L-glutamate on the inner layers of the retina. Arch Ophthalmol 1957;58:193-201.
8. Olney JW. Glutamate-induced retinal degeneration in neonatal mice: electron microscopy of the acutely evolving lesion. J Neuropathol Exp Neurol 1969;28:455-74.
9. Bresnick GH. Excitotoxins: a possible new mechanism for the pathogenesis of ischemic retinal damage. Arch Ophthalmol 1989;107:339-41.
10. Kitano S, Morgan J, Caprioli J. Hypoxic and excitotoxic damage to cultured rat retinal ganglion cell. Exp Eye Res 1996;63:105-12.
11. Siliprandi R, Canella R, Carmignoto G, et al. N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina. Vis Neurosci 1992;8:567-73.
12. Pang I-H, Wexler EM, Walters RJ, et al. Protective effects of eliprodil in retinal and neuronal cells and tissues. Soc Neurosci 1996;Abstract no 5072.
13. Quigley HA. Open-angle glaucoma. N Engl J Med 1993;328:1097-106.
14. Dryer EB, Zurakowski D, Schumer RA, et al. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 1996;114:299-305.
15. Chew SJ, Ritch R. Neuro protection: the next breakthrough in glaucoma? Proceedings of the third annual optic nerve rescue and restoration think tank. J Glaucoma 1997;6:263-6.
16. Kapin MA. Pharmacoprotection of neurodegeneration. In: Drance SM, ed. Optic nerve in glaucoma. Amsterdam: Kugler, 1995:157-63.
17. Williams K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol 1993;44:851-9.
18. Carter C, Benavides J, Dana C, et al. Non-competitive NMDA receptor antagonists acting on the polyamine site. In: Meldrum BS, ed. Excitatory amino acid antagonists. Oxford: Blackwell Scientific Publications, 1991:130-63.
19. Scatton B, Giroux C, Thenot JP, et al. Eliprodil hydrochloride. Drugs of Future 1994;19:905-9.
20. Reyes M, Reyes A, Opitz T, et al. Eliprodil, a noncompetitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. Brain Res 1998;782:212-18.
21. Kapin MA, Doshi R, Chapman L, et al. Protective effects of the polyamine antagonist, eliprodil hydrochloride in retina subjected to an excitotoxic-or ischemic-insult. Soc Neurosci 1996;Abstract no 5074.
22. 125I-Ifenprodil:synthesis and characterization of binding to a polyamine-sensitive site in cerebral cortical membranes. J Neurochem 1993;61:120-6.
23. Contreras PC, Bremer ME, Rao TS. GBR12909 and fluspiriline potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain. Life Sci 1990;47:133-7.
24. 3H]ifenprodil sites in the rat brain: possible relationship to NMDAR2B receptors and calmodulin. J Neurochem 1994;63:2248-58.
25. 3H]MK-801 binding. Neurochem Res 1991;16:563-9.
26. 1-selective antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocular Pharmacol Therapeut 1996;12:401-7.
27. McPherson GA. A practical computer based approach to the analysis of radioligand binding experiments. Computer Prog in Biomed 1983;17:107-14.
28. 3H] ifenprodil binding sites in the rat brain. Neurosci Lett 1991;125:45-8.
29. Schoemaker H, Pigasse S, Caboi F, et al. Polyamine effects on radioligand binding to receptors and recognition sites. In: Carter C, ed. Neuropharmacology of polyamines. London: Academic Press, 1994;Chapter 5:107-54.
30. Shalaby IA, Chenard BL, Prochniak MA, et al. Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL820715 on hippocampal cells in culture. J Pharmacol Exp Ther 1991;260:925-45.
31. Zeevalk GD, Nicklas WJ. Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil. Dev Brain Res 1992;65:147-55.
32. Tamura Y, Sato Y, Yokota T, et al. Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of n-methyl-D-aspartate receptors in cultured cortical neurons. J Pharmacol Exp Ther 1993;265:1017-25.
33. 2+-channels in rat cultured cortical neurons. Eur J Pharmacol 1994;257:297-301.
34. Reynolds IJ, Miller RJ. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist:interaction with polyamines. Mol Pharmacol 1989;36:758-65.
35. 3H]spermidine from rat striatal slices in vitro. J Neurochem 1994;62:1835-9.
36. London ED, Kukhin A. Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor. Ann NY Acad Sci 1995;757:430-6.
37. Seiler N. Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach. Prog Drug Res 1991;37:107-56.
38. Whittmore ER, Ilyin VI, Woodward RM, Antagonism of N-methyl-D-aspartate by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Expt Ther 1997;282:326-38.
39. Menniti F, Chenard B, Collins M, et al. CP-101,606, a potent neuroprotectant selective for forebrain neurons. Eur J Pharmacol 1997;331:117-26.
40. Fisher G, Mutel V, Trube G, et al. Ro-25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 1997;283:1285-92.
41. Valentine TL, Lukasiewicz PD, Romano C. Immunocytochemical localization of polyamines in the tiger salamander retina. Brain Res 1996;713:278-85.
42. Tanabe-ohuchi T, Yoshimura N, Shigemoto R, et al. Localization of NMDA and metabotropic glutamate receptors in the rat retina by in situ hybridization technique. Invest Ophthalmol Vis Sci (suppl) 1992;4:16934.,