Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems

Molecular and Biochemical Parasitology

Volumn 100, Issue 1, 1999, Pages 53-59

  Hunger Glaser, Isabel ^a   Brun, Reto ^b   Linder, Markus ^a   Seebeck, Thomas ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Chemotherapy; Histidine kinase; Leishmania donovani; Parasite; Succinyl CoA synthetase; Trypanosoma brucei

Indexed keywords

ANTIINFECTIVE AGENT; HISTIDINE; LY 26650; SUCCINYL COENZYME A SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LEISHMANIA DONOVANI; MITOCHONDRIAL RESPIRATION; NONHUMAN; PARASITE DEVELOPMENT; PHOSPHORYLATION; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ANIMALS; ENZYME INHIBITORS; HISTIDINE; HUMANS; LEISHMANIA DONOVANI; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SIGNAL TRANSDUCTION; SUCCINATE-COA LIGASES; THIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 0032966839     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00032-8     Document Type: Article

References (25)

1. Hoch JA, Silhavy TJ, editors. Two Component Signal Transduction, Washington: ASM Press, 1996.
2. Zhang W., Brooun A., McCandless J., Banda P., Alam M. Signal transduction in the archaeon Halobacterium salinarium is processed through three subfamilies of 13 soluble and membrane-bound transducer proteins. Proc. Natl. Acad. Sci. USA. 93:1996;4649-4654.
3. Appleby J.L., Parkinson J.S., Bourret R.B. Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled. Cell. 86:1996;845-848.
4. Roychoudhoury S., Zielinski N.A., Ninfa A.J., Allen N.E. Inhibitorsof two-component signal transduction systems: inhibition of alginate gene activation in Pseudomonas aeruginosa. Proc.Natl.Acad. Sci.USA. 90:1993;965-969.
5. Alex L.A., Simon M.I. Protein histidine kinases and signal transduction in prokaryotes and eukaryotes. Trends Genet. 10:1994;133-138.
6. Loomis W.F., Shaulsky G., Wang N. Histidine kinases in signal transduction pathways of eukaryotes. J. Cell Sci. 110:1997;1141-1145.
7. Kowluru A., Seavey S.E., Rhodes C.J., Metz S. A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. Biochem. J. 313:1996;97-107.
8. Wieland T., Nuernberg B., Ulibarri I., Kaldenberg-Stasch S., Schultz G., Jakobs K. Guanine nucleotide-specific phosphate transfer by guanine nucleotide-binding regulatory protein beta-subunits. Characterization of the phosphorylated amino acid. J. Biol. Chem. 268:1993;18111-18118.
9. Crovello C.S., Furie B.C., Furie B. Histidine phosphorylation of P-selectin upon stimulation of human platelets: a novel pathway for activation-dependent signal transduction. Cell. 82:1995;279-286.
10. Nishimura J.S. Succinyl-CoA synthetase structure-function relationships and other considerations. Adv. Enyzmol. 58:1986;141-172.
11. Veron M., Tepper A., Hildebrand M., Lascu I., Lacombe M.L., Janin J., Morera S., Cherfils J., Dumas C., Chiadmi M. Nucleoside diphosphate kinase: an old enzyme with new functions? Adv. Exp. Med. Biol. 370:1994;607-611.
12. Wagner P.D., Steeg P.S., Vu N.D. Two-component kinase-like activity of nm23 correlates with its motility-suppressing activity. Proc. Natl. Acad. Sci.USA. 94:1997;9000-9005.
13. DelaRosa A., Williams R.L., Steeg P.S. Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions. BioEssays. 17:1995;53-62.
14. Lazarowski E.R., Hmolya L., Boucher R.C., Harden T.K. Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. J. Biol. Chem. 272:1997;20402-20417.
15. Jenkins T.M., Weitzman P.D.J. Distinct physiological roles of animal succinate thiokinases. Association of guanine nucleotide-linked succinate thiokinase with ketone body utilization. FEBS Lett. 205:1986;215-218.
16. Hunge-Glaser I, Linder M, Seebeck T. Histidine-phosphorylation of succinyl CoA synthetase from Trypanosoma brucei. Mol. Biochem. Paracitol. 1999;100.
17. Cross G.A.M., Manning J.C. Cultivation of Trypanosoma brucei sspp. in semi-defined and defined media. Parasitology. 67:1973;315-331.
18. Brun R., Schoenenberger M. Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Acta Trop. 36:1979;289-292.
19. Baltz T., Baltz D., Giroud C., Crockett J. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J. 4:1985;1273-1277.
20. Bordier C. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 26:1981;1604-1607.
21. Morrison J.F., Walsh C.T. The behavior and significance of slow-binding enzyme inhibitors. Adv. Enzymol. 61:1988;201-301.
22. Brun R., Lun Z.R. Drug sensitivity of Chinese Trypanosoma evansi and Trypanosoma equiperdum isolates. Vet. Parasitol. 52:1994;37-46.
23. Obexer W., Schmid C., Brun R. Activity and structure relationship of acridine derivatives against African trypanosomes. Trop. Med. Parasitol. 46:1995;45-48.
24. Neal R.A., Croft S.L., Nelson D.J. Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026. Trans. R. Soc. Trop. Med. Hyg. 79:1985;122-128.
25. Jenkins T.M., Eisenthal P., Weitzman P.D.J. Two distinct succinate thiokinases in both bloodstream and procyclic forms of Trypanosoma brucei. Biochem. Biophys. Res. Commun. 151:1988;257-261.