Release kinetics of a controlled-release multiparticulate dosage form prepared using a hot-melt fluid bed coating method

Pharmaceutical Development and Technology

Volumn 4, Issue 1, 1999, Pages 117-124

  Griffin, E Nicholas ^a,b   Niebergall, Paul J ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Chlorpheniramine maleate; Controlled release; Higuchi equation; Hot melt coating; Multiparticulate dosage forms; Release kinetics; Wax

Indexed keywords

CHLORPHENIRAMINE MALEATE;

ARTICLE; CONTROLLED DRUG RELEASE; DISSOLUTION; DRUG FORMULATION; NONLINEAR SYSTEM; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

CHLORPHENIRAMINE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EXCIPIENTS; HEAT; KINETICS; LINEAR MODELS; SOLUBILITY; SURFACE PROPERTIES; WAXES;

EID: 0032966639     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101346     Document Type: Article

References (16)

1. A. S. Achanta, P. S. Adusumilli, K. W. James, and C. T. Rhodes, Development of hot melt coating methods, Drug Dev. Ind. Pharm., 23(5), 441-449 (1997).
2. R. Bodmeier, O. Paeratakul, H. Chen, and W. Zhang, Formation of sustained release wax matrices with hard gelatin capsules in a fluidized bed, Drug Dev. Ind. Pharm., 16(9), 1505-1519 (1990).
3. M. J. Jozwiakowski, D. M. Jones, and R. M. Franz, Characterization of a hot-melt fluid bed coating process for fine granules, Pharm. Res., 7(11), 1119-1126 (1990).
4. S. C. Porter and I. Ghebre-Sellassie, Key factors in the development of modified-release pellets, in Multiparticulate Oral Drug Delivery (I. Ghebre-Sellassie, ed.), Marcel Dekker, Inc., New York, 1994, pp. 217-283.
5. P. Prinderre, E. Cauture, J. Joachim, N. Farah, Ph. Barthelemy, and J. P. Laforet, Compritol 888 ATO; an innovative hot melt coating agent, Poster PT 6210, Annual AAPS Meeting, Miami, FL, 1995.
6. N.A. Peppas, Mathematical modeling in diffusion process in drug delivery polymeric systems, in Controlled Drug Bioavailability, Volume 1: Drug Product Design and Performance (V.F. Smolen and L. Ball, eds.), Wiley, New York, 1984, pp. 203-237.
7. J. P. Kennedy and P. J. Niebergall, Development and optimization of a solid dispersion hot-melt fluid bed coating method, Pharm. Dev. Technol., 1(1), 51-62 (1996).
8. G. Zhang, J. B. Schwartz, and R. L. Schnaare, Bead coating. I. Change in release kinetics (and mechanism) due to coating levels, Pharm. Res., 8(3), 331-335 (1991).
9. Scientist Handbook, Revision 7EEF, Chapter 13, Statistical Output, MicroMath, Inc., 1995.
10. N. K. Ebube, A. H. Hikal, C. M. Wyandt, D. C. Beer, L. G. Miller, and A. B. Jones, Sustained release of acetaminophen from heterogeneous matrix tablets: influence of polymer ratio, polymer loading, and co-active on drug release, Pharm. Dev. Technol., 2(2), 161-170 (1997).
11. C. M. Adeyeye and J. C. Price, Development and evaluation of sustained-release ibuprofen-wax microspheres. II. In vitro dissolution studies, Pharm. Res., 11(4), 575-579 (1994).
12. L. Kirilmaz, A. Kendirci, and T. Guneri, Sustained-release dosage form of oxolamine citrate: preparation and release kinetics, J. Microencapsulation, 9(2), 167-172 (1992).
13. V. R. K. Sista and P. J. Niebergall, Development and optimization of a dry coating process for sustained release formulations, Ph.D. dissertation submitted to the faculty of the Medical University of South Carolina, Charleston, South Carolina, 1994.
14. L. J. Thomsen, T. Schaefer, J. M. Sonnergaard, and H. G. Kristensen, Prolonged release matrix pellets prepared by melt pelletization. I. Process variables, Drug Dev. Ind. Pharm., 19(15), 1867-1887 (1993).
15. J. B. Dressman, B. O. Palsson, A. Ozturk, and S. Oztur, Mechanisms of release of coated pellets, in Multiparticulate Oral Drug Delivery (I. Ghebre-Sellassie, ed.), Marcel Dekker, Inc., New York, 1994, pp. 285-306.
16. T. Higuchi, Mechanism of sustained action medication, theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci., 52 (12), 1145-1149 (1963).