Epilepsia partialis continua: A new manifestation of anti-Hu-associated paraneoplastic encephalomyelitis

Annals of Neurology

Volumn 45, Issue 2, 1999, Pages 255-258

  Shavit, Yaël Bellaïche ^a   Graus, Francesc ^b   Probst, Alphonse ^a   Rene, Ramon ^c   Steck, Andreas J ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BARCELONA   (Spain)

^c CSU de Bellvitge   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN;

ADULT; ARTICLE; CASE REPORT; ELECTROENCEPHALOGRAM; ENCEPHALOMYELITIS; EPILEPTIC STATE; FEMALE; HEMIPARESIS; HISTOPATHOLOGY; HUMAN; INFLAMMATORY INFILTRATE; LUNG SMALL CELL CANCER; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARANEOPLASTIC SYNDROME; PLASMAPHERESIS; PRIORITY JOURNAL; SENSORIMOTOR CORTEX;

ADULT; BIOPSY; BRAIN; ENCEPHALOMYELITIS; EPILEPSIA PARTIALIS CONTINUA; FEMALE; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PARANEOPLASTIC SYNDROMES; RNA-BINDING PROTEINS;

EID: 0032966523     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199902)45:2<255::AID-ANA18>3.0.CO;2-N     Document Type: Article

References (17)

1. Graus F, Ribalta T, Campo E, et al. Immunohistochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis. Neurology 1990;40:219-222
2. Dalmau J, Graus F, Rosenblum MK, Posner JB. Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine 1992;71:59-72
3. Henson RA, Urich H. Encephalomyelitis with carcinoma. In: Cancer of the nervous system. Oxford, UK: Henson Blackwell Scientific Publications, 1982:314-345
4. Graus F, Dalmau J, Reñé R, et al. Anti-Hu antibodies in patients with small cell lung cancer: association with complete response to therapy and improved survival. J Clin Oncol 1997; 15:2866-2872
5. Thomas JE, Reagan TJ, Klass DW. Epilepsia partialis continua. A review of 32 cases. Arch Neural 1977;34:266-275
6. Singh BM, Strobos RJ. Epilepsia partialis continua associated with nonketotic hyperglycemia: clinical and biochemical profile of 21 patients. Ann Neurol 1980;8:155-160
7. Anderson NE, Budde-Steffen C, Wiley RG, et al. A variant of the anti-Purkinje cell antibody in a patient with paraneoplastic cerebellar degeneration. Neurology 1988;38:1018-1026
8. Dalmau J, Furneaux HM, Rosenblum MK, et al. Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/ sensory neuronopathy. Neurology 1991;41:1757-1764
9. Honnorat J, Antoine JC, Dernngton E, et al. Antibodies to a subpopulation of glial cells and a 66-kDa developmental protein in patients with paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 1996;61:270-278
10. Dropcho EJ. Anti-amphiphysin antibodies with small-cell lung carcinoma and paraneoplastic encephalomyelitis. Ann Neurol 1996;39:659-667
11. Rogers SW, Andrews PI, Gahring LC, et al. Autoantibodies to glutamate receptor GLuR3 in Rasmussen's encephalitis. Science 1994;265:648-652
12. Gahring LC, Twyman RE, Greenlee JE, Rogers SW. Autoantibodies to neuronal glutamate receptors in patients with paraneoplastic neurodegenerative syndrome enhance receptor activation. Molecular Medicine 1995;1:245-253
13. Degenhardt A, Hoard R, Duvoisin RM, et al. Glutamate receptor antibodies and paraneoplastic neurologic disorders. Neurology 1996;46:A410 (Abstract)
14. Darnell RB. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. Proc Nad Acad Sci USA 1996;93:4529-4536
15. Manley GT, Smitt PS, Dalmau J, Posner JB. Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann Neurol 1995;38:102-110
16. Jean WC, Dalmau J, Ho A, Posner JB. Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology 1994;44:140-147
17. Dalmau J, Graus F, Cheung NV, et al. Major histocompatibilitv proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 1995;75:99-109