Facilitation of spontaneous defibrillation by moxonidine during regional ischaemia in an isolated working rabbit heart model

European Journal of Pharmacology

Volumn 367, Issue 1, 1999, Pages 25-32

  Wolk, Robert ^a   Kane, Kathleen A ^b   Cobbe, Stuart M ^a   Hicks, Martin N ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Arrhythmia; Chemical defibrillation; Labetalol; Moxonidine; Myocardial ischaemia

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; LABETALOL; MOXONIDINE;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEFIBRILLATION; FACILITATION; HEART CONDUCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REFRACTORY PERIOD; HEART MUSCLE REPERFUSION; HEART VENTRICLE FIBRILLATION; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACTION POTENTIALS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ARRHYTHMIA; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; HEART VENTRICLES; HEMODYNAMIC PROCESSES; IMIDAZOLES; LABETALOL; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; ORGAN SIZE; RABBITS; VENTRICULAR FIBRILLATION;

EID: 0032966491     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00939-X     Document Type: Article

References (21)

1. Brittain R.T., Drew G.M., Levy G.P. The α- and β-adrenoceptor blocking potencies of labetalol and its individual stereoisomers in anaesthetized dogs and in isolated tissues. Br. J. Pharmacol. 77:1982;105-114.
2. 1-imidazoline receptors. J. Cardiovasc. Pharmacol. 20:1992;S1-S10. (Suppl. 4).
3. 1-imidazoline sites. J. Pharmacol. Exp. Ther. 264:1993;172-182.
4. Ernsberger P., Elliot H.L., Weimann H.-J., Raap A., Haxhiu M.A., Hofferber E., Löw-Kröger A., Reid J.L., Mest H.-J. Moxonidine: a second generation central antihypertensive agent. Cardiovasc. Drug Rev. 11:1993;411-431.
5. 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves. Naunyn-Schmiedeberg's Arch. Pharmacol. 348:1993;127-133.
6. Gold E.H., Chang W., Cohen M., Baum T., Ehrreich S., Johnson G., Prioli N., Sybertz E.J. Synthesis and comparison of some cardiovascular properties of the stereoisomers of labetalol. J. Med. Chem. 25:1982;1363-1370.
7. 2-adrenoceptors. J. Cardiovasc. Pharmacol. 20:1992;S16-S20. (Suppl. 4).
8. Hayashi Y., Kamibayashi T., Maze M., Yamatodani A., Sumikawa K., Kuro M., Yoshiya I. Role of imidazoline-preferring receptors in the genesis of epinephrine-induced arrhythmias in halothane-anasthetized dogs. Anesthesiology. 78:1993;524-530.
9. Hicks M.N., Cobbe S.M. Effect of glibenclamide on extracellular potassium accumulation and the electrophysiological changes during myocardial ischaemia in the arterially perfused interventricular septum of rabbit. Cardiovasc. Res. 25:1991;407-413.
10. Janse M.J. To prolong refractoriness or to delay conduction (or both)? Eur. Heart J. 13:1992;14-18. (Suppl. F).
11. Janse M.J., Wit A.L. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischaemia and infarction. Physiol. Rev. 69:1989;1049-1169.
12. ATP channels in guinea pig ventricular myocytes. Eur. J. Pharmacol. 285:1995;309-312.
13. Leprán J., Papp J.G. Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion. J. Cardiovasc. Pharmacol. 24:1994;S9-S15. (Suppl. 1).
14. 1-imidazoline receptor modulator moxonidine on oubain-induced cardiac arrhythmia in guinea pigs. Ann. NY Acad. Sci. 763:1995;620-633.
15. Molderings G.J., Hentrich F., Göthert M. Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 344:1991;630-638.
16. 1-imidazoline receptor agonists in the treatment of hypertension: an appraisal of clinical experience. J. Cardiovasc. Pharmacol. 24:1994;S39-S48. (Suppl. 1).
17. Ryan T.J., Anderson J.L., Antman E.M., Braniff B.A., Brooks N.H., Califf R.M., Hillis L.D., Hiratzka L.F., Rapaport E., Riegel B.J., Russell R.O., Smith E.E. Jr., Weaver W.D. ACC/AHA guidelines for the management of patients with acute myocardial infarction: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). Circulation. 94:1996;2341-2350.
18. Schwartz, P.J., Priori, S.G., 1990. Sympathetic nervous system and cardiac arrhythmias. In: Zipes, D.P., Jalife, J. (Eds.), Cardiac Electrophysiology. From Cell to Bedside. WB Saunders, Philadelphia, pp. 330-343.
19. Wilde A.A.M., Janse M.J. Electrophysiological effects of ATP potassium channel modulation: implications for arrhythmogenesis. Cardiovasc. Res. 28:1994;16-24.
20. Wolk R., Cobbe S.M., Hicks M.N., Kane K.A. Effects of lignocaine on dispersion of repolarisation and refractoriness in a working rabbit heart model of regional myocardial ischaemia. J. Cardiovasc. Pharmacol. 31:1998;253-261.
21. Wolk, R., Cobbe, S.M., Kane, K.A., Hicks, M.N., 1998b. Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium. A study with cromakalim, 5-hydroxydecanoate and glibenclamide. J. Cardiovasc. Pharmacol., in press.