Changes in myocardial oxygenation and perfusion under pharmacological stress with dipyridamole: Assessment using T*2 and T1 measurements

Magnetic Resonance in Medicine

Volumn 41, Issue 4, 1999, Pages 686-695

  Wacker, Christian M ^a,b   Bock, Michael ^c   Hartlep, Andreas W ^a,b   Beck, Gabriele ^a   Van Kaick, Gerhard ^a   Ertl, Georg ^b   Bauer, Wolfgang R ^b   Schad, Lothar R ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Tumorzentrum Heidelberg/Mannheim   (Germany)

Author keywords

Blood oxygen level dependent (BOLD); Dipyridamole pharmacology; Heart physiology; Magnetic resonance imaging; Myocardial oxygenation; Myocardial perfusion; Stress test

Indexed keywords

BLOOD; COMPUTER AIDED DESIGN; DIAGNOSIS; DISEASES; ECONOMICS; MAGNETIC RESONANCE IMAGING; NONINVASIVE MEDICAL PROCEDURES; OXYGENATION;

BLOOD OXYGEN LEVEL DEPENDENTS; CORONARY ARTERY DISEASE; DIPYRIDAMOLE; GRADIENT ECHO SEQUENCES; MYOCARDIAL PERFUSION; NON-INVASIVE ASSESSMENTS; PHARMACOLOGICAL STRESS; STRESS TEST;

OXYGEN SUPPLY;

DIPYRIDAMOLE;

ADULT; ARTICLE; CLINICAL ARTICLE; CORONARY ARTERY DISEASE; EXERCISE TEST; FEMALE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 0032963505     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(199904)41:4<686::AID-MRM6>3.0.CO;2-9     Document Type: Article

References (30)

1. Judd RM, Reeder SB, Atalar E, McVeigh ER, Zerhouni EA. A magnetization-driven gradient echo pulse sequence for the study of myocardial perfusion. Magn Reson Med 1995;34:276-282.
2. Wilke N, Simm C, Zhang J, Ellermann J, Ya X, Merkle H, Path G, Ludemann H, Bache RJ, Ugurbil K. Contrast-enhanced first pass myocardial perfusion imaging: correlation between myocardial blood flow in dogs at rest and during hyperemia. Magn Reson Med 1993;29:485-497.
3. Wilke N, Jerosch-Herold M, Stillman AE, Kroll K, Tsekos N, Merkle H, Parish T, Hu X, Wang Y, Bassingthwaighte J, Bache RJ, Ugurbil K. Concepts of myocardial perfusion imaging in magnetic resonance imaging. Magn Reson Q 1994;10:249-286.
4. Wilke N, Kroll K, Merkle H, Wang Y, Ishibashi Y, Xu Y, Zhang J, Jerosch-Herold M, Muhler A, Stillman AE, et al. Regional myocardial blood volume and flow: first-pass MR imaging with polylysine-Gd-DTPA. J Magn Reson Imaging 1995;5:227-237.
5. 1 enhancement during bolus administration of MR contrast agents. Magn Reson Med 1995;33:215-223.
6. Saeed M, Wendland MF, Higgins CB. The developing role of magnetic resonance contrast media in the detection of ischemic heart disease. Proc Soc Exp Biol Med 1995;208:238-254.
7. Edelmann RR, Li W. Contrast-enhanced echo-planar MR imaging of myocardial perfusion: preliminary study in humans. Radiology 1994; 190:771-777.
8. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 1990;87:9868-9872.
9. Ogawa S, Tank DW, Menon R, Ellerman JM, Kim S-G, Merkle H, Urgubil K. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992;89:5951-5955.
10. Li D, Dhawale P, Rubin PJ, Haacke EM, Gropler RJ. Myocardial signal response to dipyridamole and dobutamine: demonstration of the BOLD effect using a double-echo gradient-echo sequence. Magn Reson Med 1996;36:16-20.
11. Williams DS, Grandis DJ, Zhang W, Koretsky AP. Magnetic resonance imaging of perfusion in the isolated rat heart using spin inversion of arterial water. Magn Reson Med 1993;30:361-365.
12. 1 after slice selective spin inversion in the isolated cardioplegique rat heart. Magn Reson Med 1997;38:917-923.
13. Kahler E, Belle V, Waller C, Rommel E, Hiller KH, Voll S, Bauer WR, Haase A. Quantitative determination of perfusion and regional blood volume in rat myocardium in vivo. ESMRMB, 14th Annual Meeting, Bruessel, Book of Abstracts, 1997. p 91-92.
14. McGuinness ME, Talbert RL. Pharmacological stress testing: experience with dipyridamole, adenosine and dobutamine. Am J Hosp Pharm 1994;51:328-346.
15. Atkinson D, Brant Zawadzki M, Gillan G, Purdy D, Laub G. Improved MR angiography: magnetization transfer suppression with variable flip angle excitation and increased resolution. Radiology 1994;190:890-894.
16. 1-measurements in the heart. Fourth Scientific Meeting of the ISMRM, New York, 1996. p 653.
17. 1-maps of the human heart acquired in a single breathhold. Fifth Scientific Meeting of the ISMRM, Vancouver, 1997. p 2057.
18. Blueml S, Schad LR, Stepanow B, Lorenz WJ. Spin-lattice relaxation time measurement by means of a TurboFLASH technique. Magn Reson Med 1993;30:289-295.
19. Press WH, Flannery BP, Teukolsky SA, Vetterling WT. Numerical recipes: the art of scientific computing. Cambridge University Press; 1986.
20. Tauchert M, Hilger HH. In: Schaper W, editor. The pathophysiology of myocardial perfusion. Elsevier/North Holland: Amsterdam, 1979. p 141.
21. Bing RJ, Hammond MM, Handelsman JC, Powers SR, Spenger FC, Eckenhoff JE, Goodale WT, Hafkenschiel JH, Kety SS. The measurement of coronary blood flow, oxygen consumption, and efficiency of the left ventricle in man. Am Heart J 1949;38:1.
22. Kaul S, Jayaweera AR. Coronary and myocardial blood volumes. Circulation 1997;96:719-724.
23. Niemi P, Poncelet BP, Kwong KK, Weisskoff RM, Rosen BR, Brady TJ, Kantor HL. Myocardial intensity changes associated with flow stimulation in blood oxygenation sensitive magnetic resonance imaging. Magn Reson Med 1996;36:78-82.
24. 2 in the capillary network of myocardium. Magn Reson Med 1999;41:51-62.
25. 2 and field inhomogeneity: implications for cardiac EPI. Sixth Scientific Meeting of the ISMRM, Sydney, 1998. p 797.
26. Atalay MK, Poncelet BP, Kantor HL, Brady TJ, Weisskoff RM. Susceptibility artifact at the cardiac apex of porcine hearts at 3T is primarily due to the heart-lung interface. Sixth Scientific Meeting of the ISMRM, Sydney, 1998. p 130.
27. 2 in the isolated, perfused rabbit heart at 4.7 T. Magn Reson Med 1995;34:623-627.
28. Janick PA, Hackeney DB, Grossmann RI, Asakura T. MR imaging of various oxidation states of intracellular and extracellular hemoglobin. AJNR 1991;12:891-897.
29. Gomori JM, Grossman RI, Yu-Ip C, Asakura T. NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity. J Comput Assist Tomogr 1987;11:684-690.
30. Bryant RG, Marill K, Blackmore C, Francis C. Magnetic relaxation in blood and blood clots. Magn Reson Med 1990;13:133-144.