Clozapine restores water balance in schizophrenic patients with polydipsia-hyponatremia syndrome

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 11, Issue 1, 1999, Pages 86-90

  Canuso, Carla M ^b   Goldman, Morris B ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; NEUROLEPTIC AGENT;

ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; DRUG TOLERABILITY; FLUID BALANCE; HUMAN; HYPONATREMIA; MALE; PLASMA OSMOLALITY; POLYDIPSIA; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 0032963313     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.11.1.86     Document Type: Article

References (22)

1. de Leon J, Verghese C, Tracy JI, et al: Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature. Biol Psychiatry 1994; 35:519-530
2. Goldman MB, Luchins DJ, Robertson GL: Mechanisms of altered water metabolism in psychotic patients with polydipsia and hyponatremia. N Engl J Med 1988; 318:397-403
3. Goldman MB, Robertson GL, Luchins DJ: Psychotic exacerbations and enhanced vasopressin secretion in schizophrenics with hyponatremia and polydipsia. Arch Gen Psychiatry 1997; 54:443-449
4. Vieweg WVR: Treatment strategies in the polydipsia hyponatremia syndrome. J Clin Psychiatry 1994; 55:154-160
5. Ogilvie AD, Cory MF: Clozapine and hyponatremia (letter). Lancet 1992; 340:672
6. Gupta S, Baker P: Clozapine treatment of polydipsia. Ann Clin Psychiatry 1994; 6:135-137
7. de Leon J, Verghese C, Stanilla JK, et al: Treatment of polydipsia and hyponatremia in psychiatric patients: can clozapine be a new option? Neuropsychopharmacology 1995; 12:133-138
8. Lyster C, Miller AL, Seidel D, et al: Polydipsia and clozapine. Hosp Community Psychiatry 1994; 45:610-611
9. Munn NA: Resolution of polydipsia and hyponatremia in schizophrenic patients after clozapine treatment. J Clin Psychiatry 1993; 54:439-440
10. Henderson DC, Goff DC: Clozapine for polydipsia and hyponatremia in chronic schizophrenics. Biol Psychiatry 1994; 36:768-770
11. Lee HS, Swon KY, Alphs LD, Meltzer HY: Effect of clozapine on psychogenic polydipsia in chronic schizophrenia. J Clin Psychopharmacol 1991; 11:222-223
12. Spears MN, Leadbetter RA, Shutty MS: Clozapine treatment in polydipsia and intermittent hyponatremia. J Clin Psychiatry 1996; 57:123-128
13. Wakefield T, Colls I: Clozapine treatment of a schizophrenic pa-tient with polydipsia and hyponatremia. Am J Psychiatry 1996; 153:445-446
14. Fuller MA, Jurjus G, Kwon K, et al: Clozapine reduces water-drinking behavior in schizophrenic patients with polydipsia. J Clin Psychopharmacol 1996; 16:329-332
15. Millson RC, Emes CE, Glackman WG: Self induced water intoxication treated with risperidone. Can J Psychiatry 1996; 41:648-650
16. Richelson E: Preclinical pharmacology of neuroleptics: focus on new generation compounds. J Clin Psychiatry 1996; 57 (suppl 11):4-11
17. Littrell KH, Johnson CG, Littrell SH, et al: Effects of olanzapine on polydipsia and intermittent hyponatremia (letter). J Clin Psychiatry 1997; 58:549
18. Lawson WB, Karson CN, Bigelow LB: Increased urine volume in chronic schizophrenic patients. Psychiatry Res 1985; 14:323-331
19. Goldman MB, Robertson GL, Luchins DJ, et al: The influence of polydipsia on water excretion in hyponatremic, polydipsic schizophrenic patients. J Clin Endocrinol Metab 1996; 81:1465-1470
20. Umbricht DS, Saltz B, Pollack S, et al: Polydipsia and tardive dyskinesia in chronic psychiatric patients: related disorders? Am J Psychiatry 1993; 150:1536-1538
21. Canuso CM, Goldman MB: The effect of neuroleptic reduction on plasma sodium in hyponatremic polydipsic schizophrenics. Psychiatry Res 1996; 63:227-229
22. Spigset O, Hedenmalm K: Hyponatremia during treatment with clomipramine, perphenazine, or clozapine: study of therapeutic drug monitoring samples. J Clin Psychopharmol 1996; 16:412-414