Human immunodeficiency virus-rich multinucleated giant cells in the colon: A case report with transmission electron microscopy, immunohistochemistry, and in situ hybridization

Modern Pathology

Volumn 12, Issue 1, 1999, Pages 75-81

  Lewin Smith, Michael ^a   Wahl, Sharon M ^b   Orenstein, Jan M ^c  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Colon; HIV; Multinucleated giant cells; TEM

Indexed keywords

ADULT; ARTICLE; CASE REPORT; COLON; COLON BIOPSY; DENDRITIC CELL; GERMINAL CENTER; GIANT CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LAMINA PROPRIA; LANGERHANS CELL; LYMPHOID HYPERPLASIA; MACROPHAGE; MALE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; VIRUS EXPRESSION;

EID: 0032963213     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Barzan L, Carbone A, Tirelli U, Crosato IM, Vaccher E, Volpe R, et al. Nasopharyngeal lymphatic tissue in patients infected with human immunodeficiency virus. Arch Otolaryngol Head Neck Surg 1990;116:928-31.
2. Stern JC, Lin P, Lucente FE. Benign nasopharyngeal masses and human immunodeficiency virus infection. Arch Otolaryngol Head Neck Surg 1990;116:206-8.
3. Rinfret A, Latendresse H, Lefebvre R, St Louis G, Jolicoeur P, Lamarre L. Human immunodeficiency virus-infected multinucleated histiocytes in oropharyngeal lymphoid tissues from two asymptomatic patients. Am J Pathol 1991;138: 421-6.
4. Burke AP, Benson W, Ribas JL, Anderson D, Chu W, Smialek J, et al. Postmortem localization of HIV-1 RNA by in situ hybridization in lymphoid tissues of intravenous drug addicts who died unexpectedly. Am J Pathol 1993;142:1701-13.
5. Shahab I, Osborne BM, Butler JJ. Nasopharyngeal lymphoid tissue masses in patients with human immunodeficiency virus-1. Cancer 1994;74:3083-8.
6. Frankel SS, Wenig BM, Burke AP, Mannan P, Thompson TDR, Abbondanzo SL, et al. Replication of HIV-1 in dendritic cell-derived synctia at the mucosal surface of the adenoid. Science 1996;272:115-7.
7. Wenig BM, Thompson LDR, Frankel SS, Burke AP, Abbondanzo SL, Sesterhenn I, et al. Lymphoid changes of the nasopharyngeal and palatine tonsils that are indicative of human immunodeficiency virus infection. Am J Surg Pathol 1996;20:572-87.
8. Frankel SS, Tenner-Racz K, Racz P, Wenig BM, Hansen CH, Heffner D, et al. Active replication of HIV-1 at the lymphoepithelial surface of the tonsil. Am J Pathol 1997;151:89-96.
9. Frankel SS, Wenig BM, Ferlito A. Human immunodeficiency virus-1 infection of the lymphoid tissues of Waldeyer's ring. Ann Otol Rhinol Laryngol 1997;106:611-8.
10. Kapadia SB, Wiley CA, Barnes L, Swerdlow SH. Characterization of multinucleated giant cells in HIV-associated Waldeyer's ring (WR) lymphoid hyperplasias and frequency associated with EBV [abstract]. Lab Invest 1997;76:115A.
11. Rosok B, Brinchmann JE, Voltersvik P, Olofsson J, Bostad L, Asjo B. Correlates of latent and productive HIV type 1 infection in tonsillar CD4+ T cells. Proc Natl Acad Sci U S A 1997;94:9332-6.
12. Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M, et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986;233:1089-93.
13. Gendelman HE, Orenstein JM, Bacca LM, Weiser B, Burger H, Kalter DC, et al. The macrophage in the persistence and pathogenesis of HIV infection. AIDS 1089;3:475-95.
14. Eilbott DJ, Peress N, Burger H, LaNeve D, Orenstein JM, Gendelman HE, et al. Human immunodeficiency virus type I in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages. Proc Natl Acad Sci U S A 1989;86:3337-41.
15. Orenstein JM, Fox C, Wahl SM. Macrophages as a source of HIV during opportunistic infections. Science 1997;276:1857-61.
16. Wahl SM, Orenstein JM. Immune stimulation and HIV replication. J Leukoc Biol 1997;62:67-71.
17. Wahl SM, Greenwell-Wild T, Peng G, Hale-Donze H, Doherty TM, Orenstein JM. Mycobacterium avium complex (MAC) augments macrophage HIV-1 production and increases CCR5 expression. Proc Natl Acad Sci U S A 1998;95:12574-9.
18. Mirra SS, Miles ML. Subplasmalemmal linear density: a mesodermal feature and a diagnostic aid. Hum Pathol 1982;13: 365-80.
19. Reid CDL, Fryer PR, Clifford C, Kirk A, Tikerpae J, Knight SC. Identification of hematopoietic progenitors of macrophages and dendritic/Langerhans' cells (DL-CFU) in human bone marrow and peripheral blood. Blood 1990;76:1139-49.
20. Betjes MGH, Haks MC, Tuk CW, Beelen RHJ. Monoclonal antibody EBM11 (anti-CD68) discriminates between dendritic cells and macrophages after short-term culture. Immunobiology 1991;183:79-87.
21. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-a cooperate in the generation of dendritic/Langerhans' cells. Nature 1992;360:258-61.
22. Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF-a. J Exp Med 1996;184:695-706.
23. Strunk D, Rappersberger K, Egger C, Strobl H, Kromer E, Elbe A, et al. Generation of human dendritic cells/Langerhans' cells from circulating CD34+ hematopoietic progenitor cells. Blood 1996;87:1292-302.