Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists

Neuroscience

Volumn 89, Issue 3, 1999, Pages 891-899

  McLeod, A L ^a   Ritchie, J ^a   Cuello, A C ^a   Julien, J P ^a   Ribeiro Da Silva, A ^a   Henry, J L ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Allodynia; CP 96,345; Hyperalgesia; Ketamine; Nerve growth factor; Tail withdrawal

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SUBSTANCE P ANTAGONIST; SUBSTANCE P RECEPTOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; GENE OVEREXPRESSION; HYPERALGESIA; LATENT PERIOD; MALE; MECHANICAL STIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSGENIC MOUSE;

ANALGESICS; ANIMALS; BIPHENYL COMPOUNDS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; HEAT; HYPERALGESIA; KETAMINE; MALE; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; NOCICEPTORS; PROMOTER REGIONS (GENETICS); REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROKININ-1; RECOMBINANT FUSION PROTEINS; SPINAL CORD; STRESS, MECHANICAL; SUBSTANCE P;

EID: 0032961947     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00365-0     Document Type: Article

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