Pharmacodynamic effects of subinhibitory concentrations of rufloxacin on bacterial virulence factors

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 5, 1999, Pages 1013-1019

  Braga, Pier Carlo ^a,b   Sala, Maria Teresa ^a   Dal Sasso, Monica ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Dept of Pharmacology ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIFLOXACIN; CINOXACIN; CIPROFLOXACIN; ENOXACIN; FLEROXACIN; LOMEFLOXACIN; NALIDIXIC ACID; NORFLOXACIN; OFLOXACIN; OXOLINIC ACID; PEFLOXACIN; PIPEMIDIC ACID; ROSOXACIN; RUFLOXACIN; SPARFLOXACIN; TEMAFLOXACIN; TOSUFLOXACIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIUM ADHERENCE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG EFFECT; DRUG HALF LIFE; ENZYME INHIBITION; ESCHERICHIA COLI; HEMAGGLUTINATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; PHAGOCYTOSIS; PHARMACODYNAMICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RESPIRATORY BURST;

EID: 0032960630     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.5.1013     Document Type: Article

References (54)

1. Abraham, S. N., and E. M. Beachey. 1985. Host defence against adhesion of bacteria to mucosal surfaces, p. 68-83. In J. J. Gallin and A. S. Fauci (ed.), Advances in host defence mechanism. Raven Press, New York, N.Y.
2. Amaral, L., U. Schwarz, and V. Lorian. 1986. Penicillin-binding proteins of filaments of Escherichia coli induced by low concentrations of nalidixic acid, oxalinic acid, novobiocin, nitrofurantoin. Drugs. Exp. Clin. Res. 12:653-656.
3. Beachev, E. M., and B. I. Eisestein. 1982. Bacterial adherence in infections diseases. Upjohn Company, Kalamazoo, Mich.
4. Bellinati-Pires, R., S. E. Melki, G. M. D. D. Colletto, and M. M. S. Carneiro-Sampaio. 1989. Evaluation of a fluorochrome assay for assessing the bactericidal activity of neutrophils in human phagocyte dysfunctions. J. Immunol. Methods 119:189-196.
5. Braga, P. C. 1994. Effects of subinhibitory concentrations of seven macrolides and four fluoroquinolones on adhesion of Staphylococcus aureus to human mucosal cells. Chemotherapy 40:304-310.
6. Braga, P. C., and G. Piatti. 1992. Influence of enoxacin sub-MICs on the adherence of Staphylococcus aureus and Escherichia coli to human buccal and urinary epithelial cells. Chemotherapy 38:261-266.
7. Braga, P. C., and G. Piatti. 1993. Favourable effects of sub-MIC rufloxacin concentrations in decreasing the pathogen-host cell adhesion. Pharmacol. Res. 28:11-19.
8. Braga, P. C., and G. Piatti. 1993. Kinetics of filamentation of Escherichia coli induced by different sub-MICs of ceftibuten at different times. Chemotherapy 39:272-277.
9. Braga, P. C., M. Dal Sasso, S. Maci, S. Reggio, and G. Piatti. 1995. Influence of subinhibitory concentrations of brodimoprim and trimethoprim on the adhesiveness, hydrophobicity, hemagglutination and motility of Escherichia coli. Chemotherapy 41:50-58.
10. Burnham, J. C. 1988. Mediation by enoxacin of adherence of Escherichia coli to uroepithelial cells. Rev. Infect. Dis. 10(Suppl.):S175.
11. Burnham, J. C., and S. A. Sonstein. 1990. Anti-virulence effects of lomefloxacin and other quinolones, abstr. 1010, p. 254. In Program and abstracts of the 30th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
12. Chapman, J. S., and N. H. Georgopapadakou. 1988. Routes of quinolone permeation in Escherichia coli. Antimicrob. Agents. Chemother. 32:438-442.
13. Chopra, I, and A. Linton, 1986. The antibacterial effects of low concentrations of antibiotics. Adv. Microbiol. Physiol. 28:212-259.
14. Costerton, J. W. 1981. Effects of antibiotics on adherent bacteria, p. 160-175. In L. D. Sabath (ed.), Action of antibiotics in patients. Hans Huber, Vienna, Austria.
15. Courthright, J. B., D. A. Turowski, and S. A. Sonstein. 1988. Alteration of bacterial DNA structure, gene expression and plasmid encoded antibiotic resistance following exposure to enoxacin. J. Antimicrob. Chemother. 21(Suppl. B):1-18.
16. Crosby, H. A., J. F. Bron, C. W. Penn, and T. S. J. Elliott. 1994. Antibiotic-induced release of endotoxin from bacteria in vitro. J. Med. Microbiol. 40:23-30.
17. Cuffini, A. M., V. Tullio, A. Allocco, G. Paizis, C. De Leo, and N. A. Carlone. 1994. Effect of rufloxacin upon non-specific immune defences: in-vitro, ex-vivo and in-vivo results. J. Antimicrob. Chemother. 34:545-553.
18. Desnottes, J. F., D. Le Roy, and N. Diallo. 1988. Effect of subminimal inhibitory concentrations of pefloxacin on the piliation and adherence of E. coli. Drugs Exp. Clin. Res. 14:629-634.
19. Diver, J. N., and R. Wise. 1986. Morphological and biochemical changes in Escherichia coli after exposure to ciprofloxacin. J. Antimicrob. Chemother. 18(Suppl. D):31-41.
20. Dougherty, T. J., and J. J. Saukkonen. 1985. Membrane permeability changes associated with DNA gyrase inhibitors in Escherichia coli. Antimicrob. Agents. Chemother. 28:200-206.
21. Douglas, L. J. 1987. Adhesion of Candida species to epithelial surfaces. Crit. Rev. Microbiol. 15:27-43.
22. Evans, D. J., Jr., D. G. Evans, L. S. Young, and J. Pitt. 1980. Hemagglutination typing of Escherichia coli: definition of seven hemagglutination types. J. Clin. Microbiol. 12:235-242.
23. Forsgren, A., and P. J. Bergkvist. 1985. Effect of ciprofloxacin on phagocytosis. Eur. J. Clin. Microbiol. 4:575-578.
24. Goldner, M., H. Farkas-Himsley, A. Kormendy, and M. Skinner. 1993. Bacterial phagocytosis monitored by fluorescence and extracellular quenching: ingestion and intracellular killing. Lab. Med. 14:291-294.
25. Guan, L., and J. C. Burnham. 1992. Postantibiotic effect of Cl-960, enoxacin and ciprofloxacin on Escherichia coli: effect on morphology and hemolysin activity. J. Antimicrob. Chemother. 29:529-538.
26. Hammami, A., S. Agueda, and M. Archambaud. 1987. Etudes in vitro des effects de l'acide oxolinique à concentratios sub-inhibitrices sur l'activité de hemagglutinés et de l'adhesion aux cellules uro-epithéliales des Escherichia coli isolés des urines. Pathol. Biol. (Paris) 35:545-550.
27. Hed, J. 1977. The extinction of fluorescence by crystal violet and its use to differentiate between attached and ingested microorganisms in phagocytosis. FEMS Microbiol. Lett. 1:357-361.
28. Hulsman, O, and R. D'Ari. 1981. An inducible DNA replication-cell division coupling mechanism in E. coli. Nature 290:797-799.
29. Ljungh, A., and T. Wadström. 1982. Salt aggregation test for measuring cell surface hydrophobicity of urinary Escherichia coli. Eur. J. Clin. Microbiol. 1:388-393.
30. Lorian, V. 1975. Some effects of subinhibitory concentrations of antibiotics on bacteria. Bull. N. Y. Acad. Med. 51:1046-1055.
31. Lorian, V., and J. Ernst. 1987. Effects of antibiotic on bacterial structure and their pathogenecity. Pathol. Biol. 35:1370-1376.
32. Lorian, V., J. Ernst, and L. Amaral. 1989. The post-antibiotic effect defined by bacteria morphology. J. Antimicrob. Chemother. 23:485-491.
33. Lorian, V., W. Tosch, and D. Joyce. 1985. Weight and morphology of bacteria exposed to antibiotics, p. 65-72. In D. Adam, H. Hahn, and W. Opferkuch. (ed.), The influence of antibiotics on the host-parasite relationship II. Springer-Verlag, Heidelberg, Germany.
34. Löwdin, G., I. D. Odenholt-Tornqvist, S. Bengtsson, and O. Cars. 1993. A new method to determine postantibiotic effect and effects of subinhibitory antibiotic concentrations. Antimicrob. Agents Chemother. 37:2200-2205.
35. Mandell, L. A., and M. Afnan. 1991. Mechanisms of interaction among subinhibitory concentrations of antibiotics, human polymorphonuclear neutrophils, and gram-negative bacilli. Antimicrob. Agents Chemother. 35:1291-1297.
36. Milatovic, D. 1982. Effect of subinhibitory antibiotic concentrations on the phagocytosis of Staphylococcus aureus. Eur. J. Clin. Microbiol. 1:97-101.
37. Milatovic, D. 1983. Antibiotics and phagocytosis. Eur. J. Clin. Microbiol. 2:414-425.
38. National Committee for Clinical Laboratory Standards. 1990. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A2. National Committee for Clinical Laboratory Standards, Wayne, Pa.
39. Odenholt-Tornqvist, I. O., E. Löwdin, and O. Cars. 1991. Pharmacodynamic effects of subinhibitory concentrations of β-lactam antibiotics in vitro. Antimicrob. Agents Chemother. 35:1834-1839.
40. Peman, J., E. Canton, M. T. Hernandez, and M. Gobernado. 1994. Intraphagocytic killing of Gram-positive bacteria by ciprofloxacin. J. Antimicrob. Chemother. 34:965-974.
41. Phillips, I., E. Culebras, F. Moreno, and F. Baquero. 1987. Induction of the SOS response by new 4-quinolones. J. Antimicrob. Chemother. 20:632-638.
42. Raponi, G., N. Keller, B. P. Overbeek, M. Rosenberg-Arska, K. P. M. van Kessel, and J. Verhoef. 1990. Enhanced phagocytosis of encapsulated Escherichia coli strains after exposure to sub-MICs of antibiotics is correlated to changes of the bacterial cell surface. Antimicrob. Agents Chemother. 34: 332-336.
43. Robinson, P., D. Wakefield, S. N. Breit, J. F. Easter, and R. Penny. 1984. Chemiluminescent response to pathogenic organisms: normal human polymorphonuclear leukocytes. Infect. Immun. 43:744-752.
44. Schaeffer, A. J., S. K. Amundsen, and L. N. Schmidt. 1979. Adherence of Escherichia coli to human urinary tract epithelial cells. Infect. Immun. 24: 753-759.
45. Schifferli, D. M., and E. M. Beachey. 1988. Bacterial adhesion: modulation by antibiotics with primary targets other than protein synthesis. Antimicrob. Agents Chemother. 32:1609-1613.
46. Schoemaker, J. M., R. C. Gayda, and A. Markovitz. 1984. Regulation of cell division in Eschenchia coli: SOS induction and cellular location of the Sul A protein, a key to lon-associated filamentation and death. J. Bacteriol. 158: 551-561.
47. Shibl, A. M. 1995. Effect of antibiotics on adherence of microorganisms to epithelial cell surfaces. Rev. Infect. Dis. 7:51-56.
48. Smith, J. T., and C. S. Lewin. 1988. Chemistry and mechanisms of action of the quinolone antibacterials. In V. T. Andriole (ed.), The quinolones. Academic Press, New York, N.Y.
49. Sonstein, S. A., and J. C. Burnham. 1993. Effect of low concentrations of quinolone antibiotics on bacterial virulence mechanisms. Diagn. Microbiol. Infect. Dis. 16:277-289.
50. Sous, H., and I. Hirsch. 1985. Bactericidal activity of phenoxymethyl-penicillin in an in-vitro model simulating tissue kinetics. J. Antimicrob. Chemother. 15(Suppl. A):233-239.
51. Svanborg-Eden, C., T. Sandberg, and K. Alestig. 1978. Decrease in adhesion of E. coli to human urinary tract epithelial cells in vitro by subinhibitory concentrations of ampicillin. Infection 6(Suppl. 1):121-124.
52. Vrane, S. J., Z. Zagar, and S. Kurbel. 1996. Influence of subinhibitory concentrations of ceftazidime, ciprofloxacin and azithromycin on the morphology and adherence of P-fimbriated Escherichia coli. J. Chemother. 8:254-260.
53. Wise, R., J. Johnson, N. O'Sullivan, J. M. Andrews, and B. P. Imbimbo. 1991. Pharmacokinetics and tissue penetration of rufloxacin, a long acting quinolone antimicrobial agent. J. Antimicrob. Chemother. 28:905-909.
54. Wise, R., J. M. Andrews, B. P. Imbimbo, and D. Honeybourne. 1993. The penetration of rufloxacin into sites of potential infection in the respiratory tract. J. Antimicrob. Chemother. 32:861-866.