Antihypertensive properties of KRN4884, a novel long-lasting potassium channel opener

Journal of Cardiovascular Pharmacology

Volumn 33, Issue 2, 1999, Pages 292-294

  Kawahara, Jun Ichi ^a   Kashiwabara, Tomoko ^a   Ogawa, Nobuyuki ^a   Okada, Yuji ^a   Izawa, Toshio ^a  

^a KIRIN BREWERY CO LTD   (Japan)

Author keywords

Blood pressure; Heart rate; Isolated rat aorta; KRN4884; Potassium channel opener; Spontaneously hypertensive rats

Indexed keywords

5 AMINO N [2 (2 CHLOROPHENYL)ETHYL] N' CYANO 3 PYRIDINECARBOXAMIDINE; GLIBENCLAMIDE; LEMAKALIM; NILVADIPINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG POTENCY; ISOLATED ARTERY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CROMAKALIM; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION; MALE; NIFEDIPINE; PYRIDINES; RATS; RATS, INBRED SHR; RATS, WISTAR; TIME FACTORS; VASODILATION;

EID: 0032959519     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199902000-00017     Document Type: Article

References (6)

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