Quinupristin/dalfopristin attenuates the inflammatory response and reduces the concentration of neuron-specific enolase in the cerebrospinal fluid of rabbits with experimental Streptococcus pneumoniae meningitis

Journal of Antimicrobial Chemotherapy

Volumn 43, Issue 1, 1999, Pages 87-94

  Trostdorf, F ^b   Reinert, R R ^b   Schmidt, H ^b   Nichterlein, T ^b   Stuertz, K ^b   Schmitz Salue, M ^b   Sadowski, I ^b   Bruck W ^b   Nau, R ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; DALFOPRISTIN PLUS QUINUPRISTIN; LIPOTEICHOIC ACID; NEURON SPECIFIC ENOLASE; TEICHOIC ACID; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL MENINGITIS; BACTERICIDAL ACTIVITY; CEREBROSPINAL FLUID; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; RABBIT; STREPTOCOCCUS PNEUMONIAE; SUBARACHNOID SPACE; TIME;

ANIMALS; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CEREBROSPINAL FLUID PROTEINS; DISEASE MODELS, ANIMAL; INFLAMMATION; LACTIC ACID; LIPOPOLYSACCHARIDES; MENINGITIS, PNEUMOCOCCAL; MICROBIAL SENSITIVITY TESTS; NEURONS; PHOSPHOPYRUVATE HYDRATASE; RABBITS; STREPTOCOCCUS PNEUMONIAE; SUBARACHNOID SPACE; TEICHOIC ACIDS; TUMOR NECROSIS FACTOR-ALPHA; VIRGINIAMYCIN;

EID: 0032959284     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/43.1.87     Document Type: Article

References (29)

1. Klugman, K. P. (1990). Pneumococcal resistance to antibiotics. Clinical Microbiology Reviews 3, 171-96.
2. Appelbaum, P. C. (1992). Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clinical Infectious Diseases 15, 77-83.
3. Viladrich, P. F., Gudiol, F., Linares, J., Rufi, G., Ariza, J. & Pallares, R. (1988). Characteristics and antibiotic therapy of adult meningitis due to penicillin-resistant pneumococci. American Journal of Medicine 84, 839-46.
4. Marton, A., Gulyas, M., Munoz, R. & Tomasz, A. (1991). Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary. Journal of Infectious Diseases 163, 542-8.
5. Bradley, J. S. & Connor, J. D. (1991). Ceftriaxone failure in meningitis caused by Streptococcus pneumoniae with reduced susceptibility to beta-lactam antibiotics. Pediatric Infectious Disease Journal 10, 871-3.
6. Figueiredo, A. M. S., Connor, J. D., Severin, A., Vaz Pato, M. V. & Tomasz, A. (1992). A pneumococcal clinical isolate with high-level resistance to cefotaxime and ceftriaxone. Antimicrobial Agents and Chemotherapy 36, 886-9.
7. Canton, E. (1993). Cefotaxime breakpoint for Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 37, 616-7.
8. Durand, M. L., Calderwood, S. B., Weber, D. J., Miller, S. I., Southwick, F. S., Caviness, V. S. et al. (1993). Acute bacterial meningitis in adults. A review of 493 episodes. New England Journal of Medicine 328, 21-8.
9. Mustafa, M. M., Ramilo, O., Mertsola, J., Risser, R. C., Beutler, B., Hansen, E. J. et al. (1989). Modulation of inflammation and cachectin activity in relation to treatment of experimental Haemophilus influenzae type b meningitis. Journal of Infectious Diseases 160, 818-25.
10. Nau, R., Zysk, G., Schmidt, H., Fischer, F. R., Stringaris, A. K., Stuertz, K. et al. (1997). Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis. Journal of Antimicrobial Chemotherapy 39, 781-8.
11. Schmidt, H., Zysk, G., Reinert, R. R., Brück, W., Stringaris, A. K., Chen, V. et al. (1997). Rifabutin for experimental pneumococcal meningitis. Chemotherapy 43, 264-71.
12. Kim, Y. S., Kennedy, S. & Täuber, M. G. (1995). Toxicity of Streptococcus pneumoniae in neurons, astrocytes, and microglia in vitro. Journal of Infectious Diseases 171, 1363-8.
13. Kim, Y. S. & Täuber, M. G. (1996). Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production. Infection and Immunity 64, 3148-53.
14. Pankuch, G. A., Jacobs, M. R. & Appelbaum, P. C. (1994). Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodology. Antimicrobial Agents and Chemotherapy 38, 2065-72.
15. Berthaud, N., Montay, G., Conard, B. J. & Desnottes, J.-F. (1995). Bactericidal activity and kinetics of RP 59500 in a mouse model of Staphylococcus aureus septicaemia. Journal of Antimicrobial Chemotherapy 36, 365-73.
16. Entenza, J. M., Drugeon, H., Glauser, M. P. & Moreillon, P. (1995). Treatment of experimental endocarditis due to erythromycin-susceptible or -resistant methicillin-resistant Staphylococcus aureus with RP 59500. Antimicrobial Agents and Chemotherapy 39, 1419-24.
17. L'Heriteau, F., Entenza, J. M., Lacassin, F., Leport, C., Glauser, M. P. & Moreillon, P. (1995). RP 59500 prophylaxis of experimental endocarditis due to erythromycin-susceptible and -resistant isogenic pairs of viridans group streptococci. Antimicrobial Agents and Chemotherapy 39, 1425-9.
18. Tarasi, A., Dever, L. L. & Tomasz, A. (1997). Activity of quinupristin/dalfopristin against Streptococcus pneumoniae in vitro and in vivo in the rabbit model of experimental meningitis. Journal of Antimicrobial Chemotherapy 39, Suppl. A, 121-7.
19. Stuertz, K., Schmidt, H., Eiffert, H., Schwartz, P., Mäder, M. & Nau, R. (1998). Differential release of lipoteichoic and teichoic acids from Streptococcus pneumoniae as a result of exposure to β-lactam antibiotics, rifamycins, trovafloxacin, and quinupristin-dalfopristin. Antimicrobial Agents and Chemotherapy 42, 277-81.
20. Bergeron, M. & Montay, G. (1997). The pharmacokinetics of quinupristin/dalfopristin in laboratory animals and in humans. Journal of Antimicrobial Chemotherapy 39, Suppl. A, 129-38.
21. Nau, R., Zysk, G., Reinert, R. R., Mergeryan, H., Eiffert, H. & Prange, H. W. (1995). Activity of fosfomycin in a rabbit model of experimental pneumococcal meningitis. Journal of Antimicrobial Chemotherapy 36, 997-1004.
22. Zysk, G., Brück, W., Gerber, J., Brück, Y., Prange, H. W. & Nau, R. (1996). Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis. Journal of Neuropathology and Experimental Neurology 55, 722-8.
23. Spangler, S. K., Jacobs, M. R. & Appelbaum, P. C. (1992). Susceptibilities of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae to RP 59500, vancomycin, erythromycin, PD 131628, sparfloxacin, temafloxacin, Win 57273, ofloxacin, and ciprofloxacin. Antimicrobial Agents and Chemotherapy 36, 856-9.
24. Nau, R., Schmidt, T., Kaye, K., Froula, J. L. & Täuber, M. G. (1995). Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits. Antimicrobial Agents and Chemotherapy 39, 593-7.
25. Dofferhoff, A. S. M., Nijland, J. H., de Vries-Hospers, H. G., Mulder, P. O. M., Weits, J. & Bom, V. J. J. (1991). Effects of different types and combinations of antimicrobial agents on endotoxin release from gram-negative bacteria: an in-vitro and in-vivo study. Scandinavian Journal of Infectious Diseases 23, 745-54.
26. Jackson, J. J. & Kropp, H. (1992). β-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime. Journal of Infectious Diseases 165, 1033-41.
27. Prins, J. M., Kuijper, E. J., Mevissen, M. L., Speelman, P. & van Deventer, S. J. (1995). Release of tumor necrosis factor alpha and interleukin 6 during antibiotic killing of Escherichia coli in whole blood: influence of antibiotic class, antibiotic concentration, and presence of septic serum. Infection and Immunity 63, 2236-42.
28. Friedland, I. R., Jafari, H., Enrett, S., Rinderknecht, S., Paris, M., Coulthard, M. et al. (1993). Comparison of endotoxin release by different antimicrobial agents and the effect on inflammation in experimental Escherichia coli meningitis. Journal of Infectious Diseases 168, 657-62.
29. Inoue, S., Takahashi, H. & Kaneko, K. (1994). The fluctuations of neuron-specific enolase (NSE) levels of cerebrospinal fluid during bacterial meningitis: the relationship between the fluctuations of NSE levels and neurological complications or outcome. Acta Paediatrica Japonica 36, 485-8.