Tizanidine protects mice against convulsions induced by lidocaine: Involvement of α2-adrenoceptors

Pharmacology and Toxicology

Volumn 84, Issue 1, 1999, Pages 29-33

  Altenburg, Sonia P ^a   Farah, Miguel B ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; LIDOCAINE; PRAZOSIN; TIZANIDINE; YOHIMBINE;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG EFFECT; DRUG RECEPTOR BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0032958778     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb02107.x     Document Type: Article

References (26)

1. Abed, W. T.: Alterations of lidocaine and pentylenetetrazol-induced convulsions by manipulation of brain monoamines. Pharmacology & Toxicology 1994, 75, 162-165.
2. Coward, D. M.: Selective muscle relaxant properties of tizanidine and examination of its mode of action. Triangle 1981, 20, 151-158.
3. Coward, D. M., J. Davies, P. Herrling & C. Rüdeberg: Pharmacological properties of tizanidine (DS 103 282). In: Der Klinische Wertung der Spastizität. eds.: B. Conrad, R. Benecke & H. J. Bauer. Schattauer Verlag, New York, 1984, pp. 61-69.
4. 2-adrenoceptors. Neurosci. Lett. 1984, 48, 197-202.
5. De Oliveira, L. F. & A. D. Breta: Effects of 5-hydroxytryptophan, iproniazid and p-chlorophenylalanine on lidocaine seizure threshold of mice. Eur. J Pharmacol. 1974, 29, 5-9.
6. Farah, M. B. & S. P. Altenburg: The effects of alpha-adrenergic agents on the liberation of tritiated noradrenaline and on the chronotropic response in the perfused and isolated cat heart. Brazil J. Med. Biol. Res. 1985, 19, 740.
7. Farah, M. B. & S. Z. Langer: Protection by phentolamine against the effects of phenoxybenzamine on transmitter release elicited by nerve stimulation in the perfused cat heart. Brit. J. Pharmacol. 1974, 52, 549-557.
8. Hoffman, B. B. & J. Lefkowitz: Catecholamines, sympathomimetic drugs and adrenergic receptors antagonists. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics. Eds.: J. G. Hardman, A. Gilman, L. E. Limbird. McGraw Hill, New York 1996, pp. 199-248.
9. Horton, R., G. Anzelak & B. Meldrum: Noradrenergic influences in sound-induced seizures. J. Parmacol. Exp. Therap. 1980, 214, 437-442.
10. Janumpalli, S., L. S. Butler, L. B. MacMillan, L. E. Limbird & J. O. McNamara: A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. J. Neurosci. 1998, 18, 2004-2008.
11. Kameyama, T., T. Nabeshima, K. Matsuno & A. Sugimoto: Comparison of aadrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse. Eur. J. Pharmacol. 1986, 125, 2257-2284.
12. Kameyama, T., T. Nabeshima, A. Sugimoto, K. Matsuno & S. Yamada: Antinociceptive action of tizanidine in mice and rats. Naunyn-Schmiedebergs Arch. Pharmacol. 1985, 330, 93-96.
13. Killian, M. & H.-H. Frey: Central monoamines and convulsive threshold in mice and rats. Neuropharmacol. 1973, 12, 681-692.
14. Kulkarni, S. K.: Actions of clonidine on convulsion and behaviour. Arch. int. Pharmacodyn. 1981, 232, 124-132.
15. Maeda-Hagiwara, M., H. Watanabe, R. Kanaoka & K. Watanabe: Reduction of centrally-stimulated gastric acid secretion by tizanidine, a new imidazoline derivative, in anesthetized rats. Arch. int. Pharmacodyn. 1985, 277, 321-327.
16. Nabeshima, T., K. Matsuno & T. Kameyama: Involvement of spinal and supraspinal structures in tizanidine-induced antinociceptive action. Neuroci. Lett. 1986a, 63, 1-4.
17. 2-adrenoceptors. Neutopharmacol. 1987, 26, 1453-1455.
18. Nabeshima, T., S. Yamada, A. Sugimoto, K. Matsuno & T. Kameyama: Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action. Pharmacol. Biochem. Behav. 1986b, 25, 835-841.
19. Nance, P. W., A. H. Shears & D. M. Nance: Clonidine in spinal cord injury. Can. Med. Ass. J. 1985, 133, 41-42.
20. 2-adrenoceptors. Eur. J. Pharmacol. 1982, 77, 163-166.
21. 2-adrenergic tonic inhibition in behaving rats. Brain Res. 1986, 375, 235-245.
22. 2-adrenoceptor mediation. Arch. int. Pharmacodyn. 1986, 282, 209-218.
23. Shipton, E. A.: Alpha-adrenergic agonists in anaesthesia and analgesia. S. Afr. Med. J. 1991, 79, 578-579.
24. Simson, P. E., M. A. Cierpal, L. E. Heyneman & J. M. Weiss: Pertussis toxin blocks the effects of α-agonists and antagonists on locus coeruleus activity in vivo. Neurosci. Lett. 1988, 89, 361- 366.
25. 2-adrenoceptors at serotoninergic axons in rat and rabbit brain cortex: evidence for pharmacological identity with α-autoreceptors. Naunyn-Schmiedeberts Arch. Pharmacol. 1994, 349, 25-33.
26. Yokoyama, M., M. Hirakawa & H. Goto: Clonidine does not affect lidocaine seizure threshold in rats. Can. J. Anaesth. 1993, 40, 1205-1209.