The unr gene: Evolutionary considerations and nucleic acid-binding properties of its long isoform product

DNA and Cell Biology

Volumn 18, Issue 3, 1999, Pages 209-218

  Ferrer, Neus ^a   Garcia Espana, Antonio ^a   Jeffers, Michael ^a   Pellicer, Angel ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID BINDING PROTEIN; RNA; SINGLE STRANDED DNA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION; GENETIC LINKAGE; MOLECULAR EVOLUTION; NONHUMAN; NORTHERN BLOTTING; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SOUTHERN BLOTTING;

3T3 CELLS; ANIMALS; BACULOVIRIDAE; BLOTTING, SOUTHERN; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COS CELLS; DNA; DNA-BINDING PROTEINS; EUKARYOTIC CELLS; EVOLUTION, MOLECULAR; GENES, RAS; HUMANS; MICE; PC12 CELLS; RATS; RATS, INBRED F344; RNA, MESSENGER; RNA-BINDING PROTEINS; SPODOPTERA; VERTEBRATES;

ANIMALIA; AVES; EUKARYOTA; MAMMALIA; REPTILIA; VERTEBRATA;

EID: 0032958085     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454999315420     Document Type: Article

References (44)

1. AUSUBEL, F.M., BRENT, R., KINGSTON, R.E., MOORE, D.D., SMITH, J.A., SEIDMAN, J.G., and STRUHL, H. (eds) (1987). Current Protocols in Molecular Biology. (Greene Publishing Associates and Wiley-Interscience, New York).
2. BARBACID, M. (1987). ras genes. Annu. Rev. Biochem. 56, 779-827.
3. BAYARSAHIAN, D., ENKHMANDAK, B., and LUKENS, L.N. (1996). Y-box proteins interact with the S1 nuclease-sensitive site in the chicken alpha 2(I) collagen gene promoter. Biochem. J. 319, 203-207.
4. BENTON, M.J. (1990). Phylogeny of the major tetrapod groups: morphological data and divergence dates. J. Mol. Evol. 30, 409-424.
5. BOUSSADIA, O., JACQUEMIN-SABLON, H., and DAUTRY. F. (1993). Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU). Biochim. Biophys. Acta 1172, 64-72.
6. BOUVET, P., and WOLFFE, A.P. (1994). A role for transcription and FRGY2 in masking maternal mRNA within Xenopus oocytes. Cell 77, 931-941.
7. BRAYER, C.D., and MCPHERSON, A. (1983). Refined structure of the gene 5 DNA binding protein from bacteriophage fd. J. Mol. Biol. 169, 565-596.
8. CAMPISI, J., GRAY, H.E., PARDEE, A.B., DEAN, M., and SONESHEIN, G.E. (1984). Cell cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell 36, 241-247.
9. CHANG, S.C., ERWIN, A.E., and LEE, A.S. (1989). Glucose related protein (GRP94) and (GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors. Mol. Cell. Biol. 9, 2153-2162.
10. D'ADAMO, D., NOVICK, S., KAHN, J.M., LEONARDI, P., and PELLICER, A. (1997). rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. Oncogene 14, 1295-1305.
11. DIDIER, D., SCHIFFENBAUER, J., WOULFE, S., ZACHEIS, M., and SCHWARTZ, B.D. (1988). Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proc. Natl. Acad. Sci. USA 85, 7322-7326.
12. DONIGER, J., and DIPAOLO, J.A. (1988). Coordinate N-ras up-regulation with mutational activation in tumorigenic guinea pig cells. Nucleic Acids Res. 16, 969-980.
13. DONIGER. J., LANDSMAN, D., GONDA, M.A., and WISTOW, G. (1992). The product of unr, the highly conserved gene upstream of N-ras, contains multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif. New Biologist 4, 389-395.
14. FIRULLI, A.B., MAIBENCO, D.C., and KINNIBURG, A.J. (1992). The identification of tandem H-DNA structure in the c-myc nuclease sensitive promoter element. Biochem. Biophys. Res. Commun. 185, 264-270.
15. 1H-NMR assignment and secondary structure of the Tyr41-His mutant of the single stranded DNA binding protein, gene V protein, encoded by the filamentous bacteriophage M13. Eur. J. Biochem. 202, 349-360.
16. FUNKE, B., ZUELENGER, B., BENAVENTE, R., SCHUSTER, T., GOLLER, M., STEVENIN, J., and HORAK, I. (1996). The mouse poly (C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 24, 3821-3828.
17. GRAUMANN, P., and MARAHIEL, M.A. (1994). The major cold shock protein of Bacillus subtilis CspB binds with high affinity to the ATTGG and CCAAT sequences in single stranded oligonucleotides. FEBS Lett. 338, 157-160.
18. GROSVELD, F., BLOM VAN ASSENDELFT, G.B., GREAVES, D.R., and KOLLIAS, G. (1987). Position independent, high level expression of the human β-globin gene in transgenic mice. Cell 51, 975-985.
19. GUERRERO, I., WONG, H., PELLICER, A., and BURSTEIN, D.E. (1986). Activated N-ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells. J. Cell. Physiol. 129, 71-76.
20. HAGAG, N., HALEGOUA, S., and VIOLA, M. (1986). Inhibition of growth factor induced differentiation of PC12 cells by antibody to ras p21. Nature 319, 680-682.
21. HORWITH, E.M., MALONEY, K.A., and LEY, T.J. (1994). A human protein containing a cold shock domain binds specifically to H-DNA upstream from the human γ-globin genes. J. Biol. Chem. 269, 14130-14139.
22. JACQUEMIN-SABLON, H., and DAUTRY, F. (1992). Organization of the unr/N-ras locus: characterization of the promoter region of the human unr gene. Nucleic Acids Res. 20, 6355-6361.
23. JACQUEMIN-SABLON, H., TRIQUENEAUX, G., DESCHAMPS, S., and LE MAIRE, M. (1994). Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains. Nucleic Acids Res. 22, 2643-2650.
24. JANKNECHT, R., DE MARTYNOFF, G., LOU, J., HIPSKIND, R.A., NORDHEIM, A., and STUNNNENBERG, H.G. (1991). Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccina virus. Proc. Natl. Acad. Sci. USA 88, 8972-8976.
25. JEFFERS, M., PACIUCCI, R., and PELLICER, A. (1990). Characterization of unr, a gene closely linked to N-ras. Nucleic Acids Res. 18, 4891-4899.
26. JEFFERS, M., and PELLICER, A. (1992). Multiple intragenic elements regulate the expression of the murine N-ras gene. Oncogene 7, 2115-2123.
27. JIANG, W., HOU, Y., and INOUYE, M. (1997). CspA, the major cold shock protein of Escherichia coli, is an RNA chaperone. J. Biol. Chem. 272, 196-202.
28. LE TEANA, A., BRANDI, A., FALCONI, M., SPURIO, R., PON, C.C., and GUALERCI, C.O. (1991). Identification of a cold shock transcriptional enhancer of the Escherichia coli gene encoding nucleoid protein H-NS. Proc. Natl. Acad. Sci. USA 88, 10907-10911.
29. LEE, C.G., and HURWITH, J. (1992). A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3′ to 5′ direction. J. Biol. Chem. 267, 4398-4407.
30. LESHKOWITZ, D., ROZENBLATT, O., NAKAMURA, T., YANO, T., DAUTRY, F., CROCE, C.M., and CANAANI, E. (1996). ALL-1 interacts with unr, a protein containing multiple cold shock domains. Oncogene 13, 2027-2031.
31. LOPEZ-FERNANDEZ, L.A., LOPEZ-ALANON, D.M., and DEL MAZO, J. (1995). Different developmental patterns of N-ras and unr gene expression in mouse gametogenic and somatic tissues. Biochim. Biophys. Acta 1263, 10-16.
32. MALTER, J.S., REED, J.C., and KAMOUN, M. (1988). Induction and regulation of CD2 mRNA in human lymphocytes. J. Immunol. 140, 3233-3236.
33. MARCU, K.B., BOSSONE, S.A., and PATEL, A.J. (1992). myc function and regulation. Annu. Rev. Biochem. 61, 809-860.
34. NICOLAIEW, N., TRIQUENEAUX, G., and DAUTRY, F. (1991). Organization of the human N-ras locus: Characterization of a gene located immediately upstream of N-ras. Oncogene 6, 721-730.
35. NODA, M., KO, M., OGURA, A., LIU, D., AMANO, T., TAKANO, T., and IKAWA, Y. (1985). Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature 318, 73-75.
36. PACIUCCI, R., and PELLICER, A. (1991). Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element. Mol. Cell. Biol. 11, 1334-1343.
37. REED, J.C., PRYTOWSKY, M.B., and NOWEL, P.C. (1988). Regulation of gene expression in lectin-stimulated or lympbokine-stimulated T lymphocytes: effect of cyclosporine. Transplantation 46, 85S-89S.
38. SETTLEMAN, J., NARASIMHAN, V., FOSTER, L.C., and WEINBERG, R.A. (1992). Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from Ras to the nucleus. Cell 69, 539-549.
39. STRAUSS, H.S., BOSTON, R.S., RECORD, M.T. JR., and BURGESS, R.R. (1981). Variables affecting the selectivity and efficiency of retention of DNA fragments by E. coli RNA polymerase in the nitrocellulose filter binding assay. Gene 13, 75-87.
40. STREBEL, K., BECK, E., STROHMAIER, K., and SCHALLTER, H. (1986). Characterization of foot and mouth disease virus gene products with antisera against bacterially synthesized fusion proteins. J. Virol. 57, 983-991.
41. TAFURI, S.R., FAMILARI, M., and WOLFFE, A. (1993). A mouse Y box protein, MSY1, is associated with paternal mRNA in spermatocytes. J. Biol. Chem. 268, 12213-12220.
42. WOLFFE, A., TAFURY, S., RANJAN, M., and FAMILIARI, M. (1992). The T-box factors: A family of nucleic acid binding proteins conserved from Escherichia coli to man. New Biol. 4, 290-298.
43. WONG, G.G., WITEK, J.S., TEMPLE, P.A., WILKENS, K.M., LEARY, A.C., LUXENBERG, D.P., JONES, S.S., BROWN, E.L., KAY, R.M., ORR, E.C., SHOEMAKER, C., GOLDE, D.W., KAUFMAN, R.J., HEWICK, R.M., WANG, E.A., and CLARK, S.C. (1985). Human GM-CSF: Molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228, 810-815.
44. YAFFE, D., NUDEL, U., MAYER, Y., and NEUMAN, S. (1985). Highly conserved sequences in the 5′ untranslated region of mRNAs coding for homologous proteins in distantly related species. Nucleic Acids Res. 13, 3723-3737.