Plasma nitrate and interferon-gamma in Trypanosoma brucei rhodesiense infections: Evidence that nitric oxide production is induced during both early blood-stage and late meningoencephalitic-stage infections

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 93, Issue 2, 1999, Pages 169-170

  MacLean, Lorna ^a   Odiit, Martin ^b   Okitoi, Dimy ^b   Sternberg, Jeremy M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b Livestock Health Research Institute Uganda   (Uganda)

Author keywords

Interferon gamma; Nitric oxide; Trypanosoma brucei rhodesiense; Trypanosomiasis

Indexed keywords

ANTITRYPANOSOMAL AGENT; GAMMA INTERFERON; MELARSOPROL; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SURAMIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD LEVEL; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; T LYMPHOCYTE; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS; UGANDA;

TRYPANOSOMA; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 0032957826     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(99)90296-1     Document Type: Article

References (16)

1. Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., Arnelle, D. R., Hollis, D., McDonald, M. I. & Granger, D. L. (1996). Nitric oxide in Tanzanian children: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. Journal of Experimental Medicine, 184, 557-567.
2. Bancroft, G. J., Sutton, A. G., Morriss, A. J. & Askonas, B. A. (1983). Production of interferons during experimental African trypanosomiasis. Clinical and Experimental Immunology, 52, 135-143.
3. Jungersten, L., Edlund, A.-S. & Wennmalm, A. (1996). Plasma nitrate as an index of nitric oxide formation in man: analysis of kinetics and confounding factors. Clinical Physiology, 16, 369-379.
4. Mabbott, N. & Sternberg, J. (1995). Bone marrow nitric oxide production and development of anemia in T. brucei infected mice. Infection and Immunity, 63, 1563-1566.
5. Mabbott, N. A., Sutherland, I. A. & Sternberg, J. M. (1994). Trypanosoma brucei is protected from the cytostatic effects of nitric oxide under in vivo conditions. Pamsitology Research, 80, 687-690.
6. Mabbott, N. A., Sutherland, I. A. & Sternberg, J. M. (1995). Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo. Parasite Immunology, 17, 143-150.
7. Mabbott, N. A., Coulson, P. S., Smythies, L. E., Wilson, R. A. & Sternberg, J. M. (1998). African trypanosome infections in mice that lack the interferon-gamma receptor: nitric oxide dependent and independent suppression of T-cell proliferative responses and the development of anaemia. Immunology, 94, 476-480.
8. Mansfield, J. M. (1994). T-cell responses to the trypanosome variant surface glycoprotein: a new paradigm? Parasitology Today, 10, 267-270.
9. Nussler, A. K., Eling, W. & Kremsner, P. G. (1994). Patients with Plasmodium falciparum malaria and Plasmodium vivax malaria show increased nitrite and nitrate plasma levels. Journal of Infectious Diseases, 169, 1418-1419.
10. Schleifer, K. W. & Mansfield, J. M. (1993). Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. Journal of Immunology, 151, 5492-5503.
11. Sternberg, J. M. (1996). Elevated serum nitrate in Trypanosoma brucei 'rhodesiense' infections: evidence for inducible nitric oxide synthesis in trypanosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 395.
12. Sternberg, J. (1998). Immunobiology of trypanosomiasis. Chemical Immunology, 70, 186-199.
13. Sternberg, J. & Mabbott, N. (1996). Nitric oxide-mediated suppression of T-cell responses during Trypanosoma brucei infection: soluble trypanosome products and interferon-gamma are synergistic inducers of nitric oxide synthase. European Journal of Immunology, 26, 539-543.
14. Sternberg, J. M., Mabbott, N. A., Sutherland, I. A. & Liew, F. Y. (1994). Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection. Infection and Immunity, 62, 2135-2137.
15. Sternberg, J. M., Njogu-Maina, N., Gichuki, C. & Ndungu, J. M. (1998). Nitric oxide production in vervet monkeys (Cercopithecus aethiops) infected with Trypanosoma brucei. Parasite Immunology, 20, 395-397.
16. WHO (1986). Epidemiology and Control of African Trypanosomiasis. Geneva: World Health Organization, Technical Report Series, no. 739.