Lessons to be learned: A case study approach: Prolonged methaemoglobinaemia due to inadvertent dapsone poisoning; treatment with methylene blue and exchange transfusion

The Journal of the Royal Society for the Promotion of Health

Volumn 119, Issue 1, 1999, Pages 52-55

  Southgate, H J ^a   Masterson, R ^a  

^a WORTHING HOSPITAL   (United Kingdom)

Author keywords

Dapsone (erroneously prescribed); haemolytic anaemia; methaemoglobinaemia; methylene blue therapy; sensorimotor neuropathy

Indexed keywords

DAPSONE; METHYLENE BLUE; SPASMOLYTIC AGENT;

ADULT; ARTICLE; BOLUS INJECTION; CASE REPORT; CONTINUOUS INFUSION; DRUG INFUSION; ERROR; EXCHANGE BLOOD TRANSFUSION; HEMOLYSIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; METHEMOGLOBINEMIA; PHARMACY; PRESCRIPTION; SENSORIMOTOR NEUROPATHY; SPINE DISEASE;

ADULT; ANTIDOTES; BACLOFEN; DAPSONE; EXCHANGE TRANSFUSION, WHOLE BLOOD; FOLIC ACID ANTAGONISTS; HEMOLYSIS; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; MEDICATION ERRORS; METHEMOGLOBINEMIA; METHYLENE BLUE; MUSCLE RELAXANTS, CENTRAL; MUSCLE SPASTICITY; MUSCLE WEAKNESS; PARAPLEGIA; PARESTHESIA;

EID: 0032957633     PISSN: 14664240     EISSN: None     Source Type: Journal    
DOI: 10.1177/146642409911900111     Document Type: Article

References (15)

1. Berlin G., Brodin B., Hilden J.O. and Martensson J. (1994-1995). Acute dapsone intoxication: a case treated with continuous infusion of methylene blue, forced diuresis and plasma exchange. J Toxicol Clin Toxicol- 22, 6, 537-548
2. Coleman M.D., Pahal K.K. and Gardiner J.M. (1996). The effect of acetylation and deacetylation on the disposition of dapsone and monoacetyl dapsone hydroxylamines in human erythrocytes in vitro. J Pharm and Pbarmacol; 48, 4, 401-406
3. Golubuff N. and Wheaton R. (1961). Methylene blue induced cyanosis and acute haemolytic anaemia complicating the treatment of methaemoglobinaemia. J Paediatr, 58, 86-89
4. Hall A.H., Kulig K.W. and Rumach B.H. (1986). Drugs and chemical induced methaemoglobinaemia. Med Toxicol; 1, 160-253
5. Lambert M., Sonnet J., Mahieu P. and Hassoun A. (1982). Delayed sulphaemoglobinaemia after dapsone intoxication. J Toxicol Clin Toxicol; 19, 1, 45-50
6. Manfredi G. and Da G. (1979). Studies on dapsone induced haemolytic anaemia. 1. Methaemoglobin production and glucose-6-phosphate dehydrogenase activity in correlation with dapsone dosage. Br J Dermatol; 100, 427-432
7. Mansouri A. (1985). Methaemoglobinaemia. Am J Med Sci; 289, 200
8. Nagai M., Yubisui T. and Yoneyama Y. (1980). Enzymatic reduction of haemoglobins IMilwaukee 1 and MSaskatoon by NADHcytochrome b 5 reductase and NADPH-flavin reductase purified from human erythrocytes. J Biol Chem; 255, 10, 4599-4602
9. Neuvonen P.J., Elonen E. and Haapanen E.J. (1983). Acute dapsone intoxication: clinical findings and effect of oral charcoal and haemodialysis on dapsone elimination. Acta Med Scan; 214, 3, 215-220
10. Orgeron J.D. (1957). Methaemoglobinaemia from eating meat with a high nitrite content. Public Health Rep; 72, 189
11. Rhodes L.E. and Coleman M.D. (1995). Dapsone-induced motor peripheral neuropathy in pemphigus foliacus. Clin Exp Dermatol; 20, 155-156
12. Rosen P.J. (1971). Failure of methylene blue treatment in toxic methaemoglobinaemia. Association with glucose-6-phosphate dehydrogenase deficiency. Ann Intern Med; 75, 83
13. Della Rovere F and Granata A. (1995). Hemoglobin oxidative stress in cancer. Anticancer Research; 15, 5B, 2089-95
14. Singley T.L. (1962). Secondary methaemoglobinaemia due to the adulteration of fish with sodium nitrite. Ann Intern Med; 57, 800
15. Waldinger T.P. and Siegle R.J. (1984). Dapsone induced peripheral neuropathy Case report and review Arch Dermatol; 120, 356-359