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0000021167
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Semantic dementia: A form of circumscribed cerebral atrophy
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Snowden J.S., Goulding P.J., Neary D. Semantic dementia: a form of circumscribed cerebral atrophy. Behav Neurol. 2:1989;167-182.
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Behav Neurol
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Snowden, J.S.1
Goulding, P.J.2
Neary, D.3
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2
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0027054098
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Semantic dementia: Progressive fluent aphasia with temporal lobe atrophy
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Hodges J.R., Patterson K., Oxbury S., Funnell E. Semantic dementia: progressive fluent aphasia with temporal lobe atrophy. Brain. 115:1992;1783-1806.
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Brain
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Hodges, J.R.1
Patterson, K.2
Oxbury, S.3
Funnell, E.4
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3
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0000051121
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Slowly progressive semantic impairment with category specificity
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Barbarotto R., Capitani E., Spinnler H., Trivelli C. Slowly progressive semantic impairment with category specificity. Neurocase. 1:1995;107-119.
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Neurocase
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Barbarotto, R.1
Capitani, E.2
Spinnler, H.3
Trivelli, C.4
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4
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84955361432
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Reversal of the concreteness effect in a patient with semantic dementia
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Breedin S.D., Saffran E.M., Coslett H.B. Reversal of the concreteness effect in a patient with semantic dementia. Cogn Neuropsychol. 11:1994;617-660.
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Cogn Neuropsychol
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Breedin, S.D.1
Saffran, E.M.2
Coslett, H.B.3
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5
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0030561307
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Living/non-living dissociation in a case of semantic dementia: A SPECT activation study
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Cardebat D., Demonet J.F., Celsis P., Puel M. Living/non-living dissociation in a case of semantic dementia: a SPECT activation study. Neuropsychologia. 34:1996;1175-1179.
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Cardebat, D.1
Demonet, J.F.2
Celsis, P.3
Puel, M.4
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6
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0032840996
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Semantic dementia: Implications for the neural basis of language and meaning
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in press
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Garrard P., Hodges J.R. Semantic dementia: implications for the neural basis of language and meaning. Aphasiology. 1999;. in press.
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(1999)
Aphasiology
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Garrard, P.1
Hodges, J.R.2
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7
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0029364201
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Charting the progression in semantic dementia: Implications for the organisation of semantic memory
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Hodges J.R., Graham N., Patterson K. Charting the progression in semantic dementia: implications for the organisation of semantic memory. Memory. 3:1995;463-495.
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(1995)
Memory
, vol.3
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Hodges, J.R.1
Graham, N.2
Patterson, K.3
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8
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0031669346
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Are living and non-living category-specific deficits causally linked to impaired perceptual knowledge? Evidence from a category-specific double dissociation
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Lambon Ralph M.A., Howard D., Nightingale G., Ellis A.W. Are living and non-living category-specific deficits causally linked to impaired perceptual knowledge? Evidence from a category-specific double dissociation. Neurocase. 4:1998;311-338.
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Lambon Ralph, M.A.1
Howard, D.2
Nightingale, G.3
Ellis, A.W.4
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9
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0031452299
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Modality-specific operations in semantic dementia
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A study of verbal and visual semantics in a single case of semantic dementia. The patient showed a marked modality-specific semantic deficit, with better performance in experimental tasks designed to investigate the preservation of nonverbal knowledge (and everyday activities) compared to tasks requiring verbal comprehension. The authors provide a detailed discussion of the implications of the results for several models of semantic memory, in particular a new neural network multimodal model of semantic memory.
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Lauro-Grotto R., Piccini C., Shallice T. Modality-specific operations in semantic dementia. Cortex. 33:1997;593-622. A study of verbal and visual semantics in a single case of semantic dementia. The patient showed a marked modality-specific semantic deficit, with better performance in experimental tasks designed to investigate the preservation of nonverbal knowledge (and everyday activities) compared to tasks requiring verbal comprehension. The authors provide a detailed discussion of the implications of the results for several models of semantic memory, in particular a new neural network multimodal model of semantic memory.
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(1997)
Cortex
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Lauro-Grotto, R.1
Piccini, C.2
Shallice, T.3
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10
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0032935471
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Disrupted temporal lobe connections in semantic dementia
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This is the first study to use functional neuroimaging in patients with semantic dementia. The authors measured PET activation during a semantic decision task in four patients with semantic dementia compared to six control subjects. The patients showed a significant reduction in activity in the left posterior inferior temporal gyrus (BA 37) compared to control subjects. By contrast, voxel-based morphometry revealed significant anterolateral temporal atrophy (particularly on the left) but no significant structural damage to BA 37. The authors suggest that the reduced regional cerebral blood flow seen in the posterior inferior temporal lobe, which is thought to be involved in lexical retrieval, is consistent with a loss of activation from the more anterior, structurally damaged temporal regions.
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Mummery C.J., Patterson K., Wise R.J.S., Vandenbergh R., Price C.J., Hodges J.R. Disrupted temporal lobe connections in semantic dementia. Brain. 122:1999;61-73. This is the first study to use functional neuroimaging in patients with semantic dementia. The authors measured PET activation during a semantic decision task in four patients with semantic dementia compared to six control subjects. The patients showed a significant reduction in activity in the left posterior inferior temporal gyrus (BA 37) compared to control subjects. By contrast, voxel-based morphometry revealed significant anterolateral temporal atrophy (particularly on the left) but no significant structural damage to BA 37. The authors suggest that the reduced regional cerebral blood flow seen in the posterior inferior temporal lobe, which is thought to be involved in lexical retrieval, is consistent with a loss of activation from the more anterior, structurally damaged temporal regions.
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(1999)
Brain
, vol.122
, pp. 61-73
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Mummery, C.J.1
Patterson, K.2
Wise, R.J.S.3
Vandenbergh, R.4
Price, C.J.5
Hodges, J.R.6
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11
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0016578503
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Selective impairment of semantic memory
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Warrington E.K. Selective impairment of semantic memory. Q J Exp Psychol. 27:1975;635-657.
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Q J Exp Psychol
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Warrington, E.K.1
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12
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0032445951
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Going, going, gone.? Implicit and explicit tests of conceptual knowledge in a longitudinal study of semantic dementia
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Presents a longitudinal investigation of the performance of a patient with semantic dementia on explicit and implicit tests of semantic memory. In the first testing session, the authors found that the patient showed priming for perceptual (e.g. fox-red) and functional (e.g. fox-sly) properties, but not category co-ordinates (e.g. fox-dog) or category labels (e.g. fox-animal). Eleven months later, only functional properties showed a robust priming effect. At the final testing session, none of the conditions primed. One interesting issue discussed in the paper was the match between the patient's performance on explicit and implicit tests of semantic knowledge (except on tests measuring the relationship between an object concept and its category label). The results are discussed with respect to the structure of conceptual knowledge.
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Tyler L.K., Moss H.E. Going, going, gone.? Implicit and explicit tests of conceptual knowledge in a longitudinal study of semantic dementia. Neuropsychologia. 36:1998;1313-1323. Presents a longitudinal investigation of the performance of a patient with semantic dementia on explicit and implicit tests of semantic memory. In the first testing session, the authors found that the patient showed priming for perceptual (e.g. fox-red) and functional (e.g. fox-sly) properties, but not category co-ordinates (e.g. fox-dog) or category labels (e.g. fox-animal). Eleven months later, only functional properties showed a robust priming effect. At the final testing session, none of the conditions primed. One interesting issue discussed in the paper was the match between the patient's performance on explicit and implicit tests of semantic knowledge (except on tests measuring the relationship between an object concept and its category label). The results are discussed with respect to the structure of conceptual knowledge.
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(1998)
Neuropsychologia
, vol.36
, pp. 1313-1323
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Tyler, L.K.1
Moss, H.E.2
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13
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0028962099
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Exploring the loss of semantic memory in semantic dementia: Evidence from a primed monitoring study
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Moss H.E., Tyler L.K., Hodges J.R., Patterson K.E. Exploring the loss of semantic memory in semantic dementia: evidence from a primed monitoring study. Neuropsychology. 9:1995;16-26.
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(1995)
Neuropsychology
, vol.9
, pp. 16-26
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Moss, H.E.1
Tyler, L.K.2
Hodges, J.R.3
Patterson, K.E.4
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14
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0028950806
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Progressive prosopagnosia associated with selective right temporal lobe atrophy: A new syndrome?
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Evans J.J., Heggs A.J., Antoun N., Hodges J.R. Progressive prosopagnosia associated with selective right temporal lobe atrophy: a new syndrome? Brain. 118:1995;1-13.
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(1995)
Brain
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Evans, J.J.1
Heggs, A.J.2
Antoun, N.3
Hodges, J.R.4
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15
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0031664686
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A reversal of the temporal gradient for famous person knowledge in semantic dementia: Implications for the neural organisation of long-term memory
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The authors report that knowledge about famous people (as measured using a Famous Names Test) was profoundly impaired in four patients with semantic dementia, suggesting that this domain of semantic memory may be affected early in the disease. A single case study also demonstrated that the integrity of semantic memory is affected by time, with better preservation of knowledge of current celebrities compared to those from other time periods in the past.
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Hodges J.R., Graham K.S. A reversal of the temporal gradient for famous person knowledge in semantic dementia: implications for the neural organisation of long-term memory. Neuropsychologia. 36:1998;803-825. The authors report that knowledge about famous people (as measured using a Famous Names Test) was profoundly impaired in four patients with semantic dementia, suggesting that this domain of semantic memory may be affected early in the disease. A single case study also demonstrated that the integrity of semantic memory is affected by time, with better preservation of knowledge of current celebrities compared to those from other time periods in the past.
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(1998)
Neuropsychologia
, vol.36
, pp. 803-825
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Hodges, J.R.1
Graham, K.S.2
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16
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0000306839
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The role of semantic memory in object use
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Presents a comprehensive study of object use in two patients, one of whom had semantic dementia. The patient with semantic dementia showed virtually normal performance on all tests of single-object use (e.g. demonstrating the appropriate use of an object, such as a pair of scissors) and on more complicated tasks of naturalistic 'multi-level' action (e.g. packing a lunch box). The results from the study suggest that the patient had good access to information about object function and could use objects appropriately. The patient made very few errors on the tests that could be attributed to faulty semantic memory, suggesting that intact semantic knowledge is not necessary or sufficient for object use.
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Buxbaum L.J., Schwartz M.F., Carew T.G. The role of semantic memory in object use. Cogn Neuropsychol. 14:1997;219-254. Presents a comprehensive study of object use in two patients, one of whom had semantic dementia. The patient with semantic dementia showed virtually normal performance on all tests of single-object use (e.g. demonstrating the appropriate use of an object, such as a pair of scissors) and on more complicated tasks of naturalistic 'multi-level' action (e.g. packing a lunch box). The results from the study suggest that the patient had good access to information about object function and could use objects appropriately. The patient made very few errors on the tests that could be attributed to faulty semantic memory, suggesting that intact semantic knowledge is not necessary or sufficient for object use.
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(1997)
Cogn Neuropsychol
, vol.14
, pp. 219-254
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Buxbaum, L.J.1
Schwartz, M.F.2
Carew, T.G.3
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17
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0027773105
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Progressive decline of semantic memory with preservation of number processing and calculation
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Diesfeldt H.F.A. Progressive decline of semantic memory with preservation of number processing and calculation. Behav Neurol. 6:1993;239-242.
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(1993)
Behav Neurol
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, pp. 239-242
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Diesfeldt, H.F.A.1
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20
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84937281374
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Progressive pure anomia: Insufficient activation of phonology by meaning
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Graham K., Patterson K., Hodges J.R. Progressive pure anomia: insufficient activation of phonology by meaning. Neurocase. 1:1995;25-38.
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(1995)
Neurocase
, vol.1
, pp. 25-38
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Graham, K.1
Patterson, K.2
Hodges, J.R.3
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21
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0030138664
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Response biases in oral reading: An account of the co-occurrence of surface dyslexia and semantic dementia
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Funnell E. Response biases in oral reading: an account of the co-occurrence of surface dyslexia and semantic dementia. Q J Exp Psychol. 49:1996;417-446.
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(1996)
Q J Exp Psychol
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, pp. 417-446
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Funnell, E.1
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22
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0027048986
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Deterioration of word meaning: Implications for reading
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Patterson K., Hodges J.R. Deterioration of word meaning: implications for reading. Neuropsychologia. 30:1992;1025-1040.
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(1992)
Neuropsychologia
, vol.30
, pp. 1025-1040
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Patterson, K.1
Hodges, J.R.2
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24
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0031667877
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Fragmented words: A case of late stage progressive aphasia
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Patterson K., Okada S., Suzuki T., Ijuin M., Tatsumi I. Fragmented words: a case of late stage progressive aphasia. Neurocase. 4:1998;219-230.
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(1998)
Neurocase
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, pp. 219-230
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Patterson, K.1
Okada, S.2
Suzuki, T.3
Ijuin, M.4
Tatsumi, I.5
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25
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0028266642
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The relationship between comprehension and oral reading in progressive fluent aphasia
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Graham K.S., Hodges J.R., Patterson K.E. The relationship between comprehension and oral reading in progressive fluent aphasia. Neuropsychologia. 32:1994;299-316.
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(1994)
Neuropsychologia
, vol.32
, pp. 299-316
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Graham, K.S.1
Hodges, J.R.2
Patterson, K.E.3
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26
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0000528864
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Lexical and semantic binding effects in short-term memory: Evidence from semantic memory
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Knott R., Patterson K., Hodges J.R. Lexical and semantic binding effects in short-term memory: evidence from semantic memory. Cogn Neuropsychol. 14:1997;1165-1216.
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(1997)
Cogn Neuropsychol
, vol.14
, pp. 1165-1216
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Knott, R.1
Patterson, K.2
Hodges, J.R.3
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27
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0028153964
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The impact of semantic memory loss on phonological representations
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Patterson K., Graham N., Hodges J.R. The impact of semantic memory loss on phonological representations. J Cogn Neurosci. 6:1994;57-69.
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(1994)
J Cogn Neurosci
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Patterson, K.1
Graham, N.2
Hodges, J.R.3
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28
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0345528471
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Progressive aphasia: Impairment of syntactic processing in a fluent patient
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Tyler L.K., Moss H.E., Hodges J.R., Patterson K. Progressive aphasia: impairment of syntactic processing in a fluent patient. Brain Lang. 47:1994;452-455.
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(1994)
Brain Lang
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Tyler, L.K.1
Moss, H.E.2
Hodges, J.R.3
Patterson, K.4
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29
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0031568851
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The gradual deterioration of syntax and semantics in a patient with progressive aphasia
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Tyler L.K., Moss H.E., Patterson K., Hodges J.R. The gradual deterioration of syntax and semantics in a patient with progressive aphasia. Brain Lang. 56:1997;426-476.
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(1997)
Brain Lang
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, pp. 426-476
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Tyler, L.K.1
Moss, H.E.2
Patterson, K.3
Hodges, J.R.4
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30
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0000244405
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Uber die Beziehungen der senilen Hirnatrophie zur Aphasie
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[Title translation: On the relationship between senile cerebral atrophy and aphasia.]
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Pick A. Uber die Beziehungen der senilen Hirnatrophie zur Aphasie. Prager Medicinische Wochenschrift. 17:1892;165-167. [Title translation: On the relationship between senile cerebral atrophy and aphasia.].
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(1892)
Prager Medicinische Wochenschrift
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, pp. 165-167
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Pick, A.1
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31
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84940806954
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Uber einen weiteren symptomenkomplex im Rahmen der Dementia senilis, bedingt durch umschriebene starkere Hirnatrophie (gemische Apraxie)
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[Title translation: On a further complex of symptoms within the group of senile dementias, caused by a pronounced, focal cerebral atrophy (mixed apraxia).]
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Pick A. Uber einen weiteren symptomenkomplex im Rahmen der Dementia senilis, bedingt durch umschriebene starkere Hirnatrophie (gemische Apraxie). Mschr Psychiat Neurol. 19:1906;97-108. [Title translation: On a further complex of symptoms within the group of senile dementias, caused by a pronounced, focal cerebral atrophy (mixed apraxia).].
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(1906)
Mschr Psychiat Neurol
, vol.19
, pp. 97-108
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Pick, A.1
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32
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0038892985
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On aphasia due to atrophy of the cerebral convolutions
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Mingazzini G. On aphasia due to atrophy of the cerebral convolutions. Brain. 36:1914;493-524.
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(1914)
Brain
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Mingazzini, G.1
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33
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0020037788
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Slowly progressive aphasia without generalised dementia
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Mesulam M.M. Slowly progressive aphasia without generalised dementia. Ann Neurol. 11:1982;592-598.
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Ann Neurol
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Mesulam, M.M.1
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34
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0018759618
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Dissociations of language function in dementia: A case study
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Schwartz M.F., Marin O.S.M., Saffran E.M. Dissociations of language function in dementia: a case study. Brain Lang. 7:1979;277-306.
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(1979)
Brain Lang
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Schwartz, M.F.1
Marin, O.S.M.2
Saffran, E.M.3
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35
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0030276202
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Nonfluent progressive aphasia and semantic dementia: A comparative neuropsychological study
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Hodges J.R., Patterson K. Nonfluent progressive aphasia and semantic dementia: a comparative neuropsychological study. J Int Neuropsychol Soc. 2:1996;511-524.
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(1996)
J Int Neuropsychol Soc
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Hodges, J.R.1
Patterson, K.2
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36
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0032004762
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Single word production in non-fluent progressive aphasia
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Croot K., Patterson K., Hodges J.R. Single word production in non-fluent progressive aphasia. Brain Lang. 61:1998;226-273.
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(1998)
Brain Lang
, vol.61
, pp. 226-273
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Croot, K.1
Patterson, K.2
Hodges, J.R.3
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39
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0031158237
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Semantic amnesia without dementia: Documentation of a case
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Rusconi M.L., Zago S., Basso A. Semantic amnesia without dementia: documentation of a case. Int J Neurol Sci. 18:1997;167-171.
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(1997)
Int J Neurol Sci
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Rusconi, M.L.1
Zago, S.2
Basso, A.3
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40
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21344443403
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Syndrome dementiel par troubles selectifs de la memoire semantique: Etude d'un cas
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[Title translation: Dementia with selective problems of semantic memory: a case study.]
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Forgeau M., Aubin G., Le Gall D., Allain P., Penisson-Besnier I., Joseph P.A., Emile J. Syndrome dementiel par troubles selectifs de la memoire semantique: etude d'un cas. Rev Neuropsychol. 6:1996;83-100. [Title translation: Dementia with selective problems of semantic memory: a case study.].
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Rev Neuropsychol
, vol.6
, pp. 83-100
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Forgeau, M.1
Aubin, G.2
Le Gall, D.3
Allain, P.4
Penisson-Besnier, I.5
Joseph, P.A.6
Emile, J.7
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41
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84963421233
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Loss of semantic memory: Implications for the modularity of mind
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Hodges J.R., Patterson K., Tyler L.K. Loss of semantic memory: implications for the modularity of mind. Cogn Neuropsychol. 11:1994;505-542.
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(1994)
Cogn Neuropsychol
, vol.11
, pp. 505-542
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Hodges, J.R.1
Patterson, K.2
Tyler, L.K.3
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42
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0030985328
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The temporal variant of frontotemporal dementia
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Reports the main clinical and neuropsychiatric features seen in the temporal variant of frontotemporal dementia (FTD) compared with the more frontal presentation of FTD. The authors found that patients with predominantly right-sided temporal damage presented with behavioural disorders, such as irritability, impulsiveness and fixed ideas. By contrast, the predominant clinical symptom in patients with more severe left temporal lobe atrophy was aphasia. The authors discuss these findings with respect to the differential roles of the right and left temporal lobes in mediating behavioural functions and the heterogeneity of frontotemporal dementia.
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Edwards Lee T., Miller B.L., Benson D.F., Cummings J.L., Russell G.L., Boone K., Mena I. The temporal variant of frontotemporal dementia. Brain. 120:1997;1027-1040. Reports the main clinical and neuropsychiatric features seen in the temporal variant of frontotemporal dementia (FTD) compared with the more frontal presentation of FTD. The authors found that patients with predominantly right-sided temporal damage presented with behavioural disorders, such as irritability, impulsiveness and fixed ideas. By contrast, the predominant clinical symptom in patients with more severe left temporal lobe atrophy was aphasia. The authors discuss these findings with respect to the differential roles of the right and left temporal lobes in mediating behavioural functions and the heterogeneity of frontotemporal dementia.
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(1997)
Brain
, vol.120
, pp. 1027-1040
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Edwards Lee, T.1
Miller, B.L.2
Benson, D.F.3
Cummings, J.L.4
Russell, G.L.5
Boone, K.6
Mena, I.7
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43
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0027199156
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Progressive right frontotemporal degeneration: Clinical, neuropsychological and SPECT characteristics
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Miller B.L., Chang L., Mena I., Boone K., Lesser I.M. Progressive right frontotemporal degeneration: clinical, neuropsychological and SPECT characteristics. Dementia. 4:1993;204-213.
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Dementia
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Miller, B.L.1
Chang, L.2
Mena, I.3
Boone, K.4
Lesser, I.M.5
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44
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13044269060
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The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of fronto-temporal dementia) from early Alzheimer's disease: A comparative neuropsychological study
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This experimental study investigated whether patients with the frontal variant of frontotemporal dementia (FTD) show a distinct cognitive profile compared to patients with the temporal lobe variant of FTD and to patients in the presumed early stages of Alzheimer's disease. The authors found strong support for this hypothesis: the predominant impairment in Alzheimer's disease was in episodic memory, whereas patients with semantic dementia showed a profound loss of semantic knowledge. By contrast, patients with the frontal variant of frontotemporal dementia were mildly impaired on episodic memory and verbal fluency.
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Hodges J.R., Patterson K., Ward R., Garrard P., Bak T., Perry R., Gregory C. The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of fronto-temporal dementia) from early Alzheimer's disease: a comparative neuropsychological study. Neuropsychology. 13:1999;31-40. This experimental study investigated whether patients with the frontal variant of frontotemporal dementia (FTD) show a distinct cognitive profile compared to patients with the temporal lobe variant of FTD and to patients in the presumed early stages of Alzheimer's disease. The authors found strong support for this hypothesis: the predominant impairment in Alzheimer's disease was in episodic memory, whereas patients with semantic dementia showed a profound loss of semantic knowledge. By contrast, patients with the frontal variant of frontotemporal dementia were mildly impaired on episodic memory and verbal fluency.
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(1999)
Neuropsychology
, vol.13
, pp. 31-40
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Hodges, J.R.1
Patterson, K.2
Ward, R.3
Garrard, P.4
Bak, T.5
Perry, R.6
Gregory, C.7
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45
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84937317859
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Semantic dementia: Autobiographical contribution to preservation of meaning
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Snowden J.S., Griffiths H.L., Neary D. Semantic dementia: autobiographical contribution to preservation of meaning. Cogn Neuropsychol. 11:1994;265-288.
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(1994)
Cogn Neuropsychol
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Snowden, J.S.1
Griffiths, H.L.2
Neary, D.3
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Autobiographical experience and word meaning
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Snowden J.S., Griffiths H.L., Neary D. Autobiographical experience and word meaning. Memory. 3:1995;225-246.
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(1995)
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Snowden, J.S.1
Griffiths, H.L.2
Neary, D.3
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47
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0001240577
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Semantic-episodic memory interactions in semantic dementia: Implications for retrograde memory function
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These authors were amongst the first to describe and investigate episodic memory in semantic dementia. In this paper, the third in a series (see [45,46]), Snowden and colleagues undertake a comprehensive series of experiments aimed at investigating the relationship between semantic and episodic memory. The paper is a useful summary of recent findings from semantic dementia, and the discussion of these results is detailed and thought-provoking.
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Snowden J.S., Griffiths H.L., Neary D. Semantic-episodic memory interactions in semantic dementia: implications for retrograde memory function. Cogn Neuropsychol. 13:1996;1101-1137. These authors were amongst the first to describe and investigate episodic memory in semantic dementia. In this paper, the third in a series (see [45,46]), Snowden and colleagues undertake a comprehensive series of experiments aimed at investigating the relationship between semantic and episodic memory. The paper is a useful summary of recent findings from semantic dementia, and the discussion of these results is detailed and thought-provoking.
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The authors describe two experiments that investigated the effects of time on autobiographical memory in semantic dementia. On the Autobiographical Memory Interview, a group of patients with semantic dementia were better at producing autobiographical memories from a very recent time-period compared to childhood and early adulthood (the opposite pattern to that seen in a group of patients with presumed early Alzheimer's disease). A second, more detailed, case-study examined the integrity of autobiographical memory for the whole of a patient's life and found that the preservation of autobiographical memories was restricted to the most recent two years.
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Graham K.S., Hodges J.R. Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage; evidence from the study of semantic dementia and Alzheimer's disease. Neuropsychology. 11:1997;77-89. The authors describe two experiments that investigated the effects of time on autobiographical memory in semantic dementia. On the Autobiographical Memory Interview, a group of patients with semantic dementia were better at producing autobiographical memories from a very recent time-period compared to childhood and early adulthood (the opposite pattern to that seen in a group of patients with presumed early Alzheimer's disease). A second, more detailed, case-study examined the integrity of autobiographical memory for the whole of a patient's life and found that the preservation of autobiographical memories was restricted to the most recent two years.
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Describes the longitudinal decline of a patient with semantic dementia and includes neuropathological findings: spongiform changes of cortical layers (II and III) in temporal, and less severely, in frontal gyri. The article highlights the fact that, while there are only a few neuropathological studies in semantic dementia, patients with the disease have Pick's disease, neuronal loss or non-specific spongiform change and gliosis without Alzheimer's or Pick's pathology.
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Schwarz M., De Bleser R., Poeck K., Weis J. A case of primary progressive aphasia: a 14-year follow-up study with neuropathological findings. Brain. 121:1998;115-126. Describes the longitudinal decline of a patient with semantic dementia and includes neuropathological findings: spongiform changes of cortical layers (II and III) in temporal, and less severely, in frontal gyri. The article highlights the fact that, while there are only a few neuropathological studies in semantic dementia, patients with the disease have Pick's disease, neuronal loss or non-specific spongiform change and gliosis without Alzheimer's or Pick's pathology.
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Describes the first detailed investigation of new learning in semantic dementia. Five patients with semantic dementia showed normal recognition memory for real and nonreal animals seen 10 minutes previously, whereas a group of patients in the presumed early stages of Alzheimer's disease were significantly impaired on the test. The authors concluded that the preservation of nonverbal recognition memory in semantic dementia supports the view that new learning depends on the hippocampus and related structures.
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Graham K.S., Becker J.T., Hodges J.R. On the relationship between knowledge and memory for pictures: evidence from the study of patients with semantic dementia and Alzheimer's disease. J Int Neuropsychol Soc. 3:1997;534-544. Describes the first detailed investigation of new learning in semantic dementia. Five patients with semantic dementia showed normal recognition memory for real and nonreal animals seen 10 minutes previously, whereas a group of patients in the presumed early stages of Alzheimer's disease were significantly impaired on the test. The authors concluded that the preservation of nonverbal recognition memory in semantic dementia supports the view that new learning depends on the hippocampus and related structures.
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in press. Two experiments investigated relearning of 'lost' vocabulary in a case of semantic dementia using category fluency. In both studies, it was found that the patient improved significantly when he practised at home with the names of concepts plus pictures and descriptions of them. When the patient stopped practising, however, his fluency scores on previously improved categories declined. The authors discuss the implications of the results for current views of long-term memory.
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Graham K.S., Patterson K., Pratt K.H., Hodges J.R. Relearning and subsequent forgetting of semantic category exemplars in a case of semantic dementia. Neuropsychology. 1999;. in press. Two experiments investigated relearning of 'lost' vocabulary in a case of semantic dementia using category fluency. In both studies, it was found that the patient improved significantly when he practised at home with the names of concepts plus pictures and descriptions of them. When the patient stopped practising, however, his fluency scores on previously improved categories declined. The authors discuss the implications of the results for current views of long-term memory.
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An elegant and detailed investigation of the integrity of stored structural descriptions in a single case of semantic dementia. The authors used tests of perceptual priming to determine whether their patient had good access to representations within stored structural descriptions. The normal perceptual priming exhibited by the patient in a number of experiments suggests that he was capable of forming and retaining the structure of objects. The authors propose that the anterior inferior temporal lobe, which was damaged bilaterally in their patient, is not involved in the storage of existing structural descriptions of known objects or the formation of new structural descriptions for novel objects.
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Srinivas K., Breedin S.D., Coslett H.B., Saffran E.M. Intact perceptual priming in a patient with damage to the anterior inferior temporal lobes. J Cogn Neurosci. 9:1997;490-511. An elegant and detailed investigation of the integrity of stored structural descriptions in a single case of semantic dementia. The authors used tests of perceptual priming to determine whether their patient had good access to representations within stored structural descriptions. The normal perceptual priming exhibited by the patient in a number of experiments suggests that he was capable of forming and retaining the structure of objects. The authors propose that the anterior inferior temporal lobe, which was damaged bilaterally in their patient, is not involved in the storage of existing structural descriptions of known objects or the formation of new structural descriptions for novel objects.
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