Special considerations in the design of trials involving children

Journal of Nutrition

Volumn 129, Issue 1 SUPPL., 1999, Pages

  Underwood, Louis E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

CATABOLISM; CHILD; CHILD DEVELOPMENT; CHILD GROWTH; CHILD NUTRITION; CLINICAL RESEARCH; CLINICAL TRIAL; CONFERENCE PAPER; GROWTH RATE; HUMAN; MALNUTRITION; MEDICAL ETHICS; NITROGEN BALANCE; NUTRITIONAL SUPPORT; RISK BENEFIT ANALYSIS;

EID: 0032956719     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.1.264s     Document Type: Conference Paper

References (18)

1. Clemmons, D. R. (1991) Insulin-like growth factor binding proteins. In: Insulin-like Growth Factors: Molecular and Cellular Aspects. (LeRoith, D., ed.). CRC Press, Boca Raton, FL. pp. 151-179.
2. Clemmons, D. R., Klibanski, A., Underwood, L. E., McArthur, J. W., Ridgway, E. C., Beitins, I. Z. & Van Wyk, J. J. (1981) Reduction of plasma immuno-reactive somatomedin-c during fasting in humans. J. Clin. Endocrinol. Metab. 53: 1247-1250.
3. Clemmons, D. R., Snyder, D. K. & Busby, W. Jr., H. (1991) Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects. J. Clin. Endocrinol. Metab. 73: 727-733.
4. Clemmons, D. R., Underwood, L. E., Dickerson, R. N., Brown, R. O., Hak, L. F., MacPhee, R. D. & Heizer, W. D. (1985) Use of plasma somatomedin-c/ insulin-like growth factor-1 measurements to monitor the response to nutritional repletion in malnourished patients. Am. J. Clin. Nutr. 41: 191-198.
5. Counts, D. R., Gwirtsman, H., Carlsson, L.M.S., Lesern, M. & Cutler, G. B. (1992) The effect of anorexia nervosa and refeeding on growth hormone binding proteins, the insulin-like growth factors (IGFs) and the IGF binding proteins. J. Clin. Endocrinol. Metab. 75: 762-767.
6. Daughaday, W. H. & Rotwein, P. (1989) Insulin-like growth factors 1 & II. Peptide, messenger ribonucleic acid and gene structures, serum and tissue concentrations. Endocr. Rev. 10: 68-91.
7. Donahue, S. P. & Phillips, L. S. (1989) Response of IGF-I to nutritional support in malnourished hospital patients: A possible indicator of short-term changes in nutritional status. Am. J. Clin. Nutr. 50: 962-969.
8. Grodin, M. A. & Glantz, L H. (1994) Appendix A. In: Children as Research Subjects: Science, Ethics and Law (Grodin, M. A. & Glantz, L. H., eds.). Oxford Univ. Press, New York, NY. pp. 215-217.
9. Isley, W. L., Underwood, L. E. & Clemmons, D. R. (1983) Dietary components that regulate serum somatomedin-c concentrations in humans. J. Clin. Invest. 71: 175-182.
10. Isley, W. L., Underwood, L. E. & Clemmons, D. R. (1984) Changes in plasma somatomedin-c in response to ingestion of diets with variable protein and energy content. J. Parenter. Enteral Nutr. 8: 407-411.
11. Kabir, I., Butler, T., Underwood, L. E. & Rahman, M. M. (1992) Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor 1. Pediatr. Res. 32: 689-692.
12. Pucilowska, J. B., Davenport, M. L., Kabir, I., Clemmons, D. R., Thissen, J-P., Butler, T. & Underwood, L. E. (1993) The effect of dietary protein supplementation on insulin-like growth factors (IGFs) on IGF-binding proteins in children with shigellosis. J. Clin. Endocrinol. Metab. 77: 1516-1521.
13. Smith, W. J., Underwood, L. E. & Clemmons, D. R. (1995) Effects of calorie or protein restriction on insulin-like growth factor 1 (IGF-I) and IGF binding proteins (IGFBPs) in children and adults. J. Clin. Endocrinol. Metab. 80: 443-449.
14. Thissen, J-P., Ketelslegers, J-M. & Underwood, L. E. (1994) Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 15: 80-101.
15. Underwood, L. E. & Van Wyk, J. J. (1991) Normal and aberrant growth. In: Williams Textbook of Endocrinology (Wilson, J. & Foster, D., eds.). WB Saunders, Philadelphia, PA. pp. 1097-1137.
16. Underwood, L E., Thissen, J-P., Lemozy, S., Ketelslegers, J-M. & Clemmons, D. R. (1994) Hormonal and nutritional regulation of IGF-I and its binding proteins. Horm. Res. 42: 145-151.
17. Underwood, L. E. (1996) Nutritional regulation of IGF-I and IGFBPs. J. Pediatr. Endocrinol. Metab. 9: 303-312.
18. Unterman, T. G., Vazquez, R. M., Sla, A. J., Martyn, P. A. & Phillips, L. S. (1985) Nutrition and somatomedin, XII: usefulness of somatomedin-c in nutritional assessment. Am. J. Med. 78: 228-234.