Cellular circadian clocks in the pineal

Progress in Neurobiology

Volumn 58, Issue 2, 1999, Pages 121-162

  Falcón, Jack ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARALKYLAMINE ACETYLTRANSFERASE; CALCIUM ION; CYCLIC NUCLEOTIDE; MELATONIN; TRANSCRIPTION FACTOR;

ANATOMY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; EVOLUTION; MAMMAL; NONHUMAN; PHOTOPERIODICITY; PHOTORECEPTOR CELL; PHOTOSENSITIVITY; PINEAL BODY; PRIORITY JOURNAL; SECOND MESSENGER; VERTEBRATE;

EID: 0032956319     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(98)00078-1     Document Type: Review

References (345)

1. Abe T., Shinohara T. S-Antigen from the rat retina and pineal gland have identical sequences. Exp. Eye Res. 51:1990;111-112.
2. Albrecht U., Sun Z. S., Eichele G., Lee C. C. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell. 91:1997;1055-1064.
3. Antoch M. P., Song E. J., Chang A. M., Vitaterna M. H., Zhao Y., Wilsbacher L. D., Sangoram A. M., King D. P., Pinto L. H., Takahashi J. S. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell. 89:1997;655-667.
4. Araki M. Cellular mechanism for norepinephrine suppression of pineal photoreceptor-like cell differentiation in rat pineal cultures. Dev. Biol. 149:1992;440-447.
5. Araki M., Tokunaga F. Norepinephrine suppresses both photoreceptor and neuron-like properties expressed by cultured rat pineal glands. Cell Differ. Dev. 31:1990;129-135.
6. Araki M., Watanabe K., Tokunaga F., Nonaka T. Phenotypic expression of photoreceptor and endocrine cell properties by cultured pineal cells of the newborn rat. Cell Differ. Dev. 25:1988;155-163.
7. Araki M., Fukada Y., Shichida Y., Yoshizawa T., Tokunaga F. Differentiation of both rod and cone types of photoreceptors in the in vivo and in vitro developing pineal glands of the quail. Dev. Brain Res. 65:1992;85-92.
8. Arendt J., Deacon S. Treatment of circadian rhythm disorders with melatonin. Chronobiol. Int. 14:1997;185-204.
9. Armstrong S. M. Melatonin and circadian control in mammals. Experientia. 45:1989;932-938.
10. Aronson B. D., Johnson K. A., Loros J. J., Dunlap J. C. Negative feedback defining a circadian clock: autoregulation of the clock gene frequency. Science. 263:1994;1578-1584.
11. Axelrod J., Quay W. B., Baker P. C. Enzymatic synthesis of the skin-lightening agent, melatonin, in amphibians. Nature. 208:1965;386.
12. Baler R., Klein D. C. Circadian expression of transcription factor Fra-2 in the rat pineal gland. J. Biol. Chem. 270:1995;27319-27325.
13. Baler R., Covington S., Klein D. C. The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex. J. Biol. Chem. 272:1997;6979-6985.
14. Barrett R. K., Takahashi J. S. Temperature compensation and temperature entrainment of the chick pineal cell circadian clock. J. Neurosci. 15:1995;5681-5692.
15. Barrett R. K., Underwood H. The superior cervical ganglia are not necessary for entrainment or persistence of the pineal melatonin rhythm in Japanese quail. Brain Res. 569:1992;249-254.
16. Bartness T. J., Goldman B. D. Mammalian pineal melatonin: a clock for all seasons. Experientia. 45:1989;939-945.
17. Bastianelli E., Pochet R. Calbindin-D28k, calretinin, and recoverin immunoreactivities in developing chick pineal gland. J. Pineal Res. 17:1994;103-111.
18. Bernard M., Voisin P., Guerlotte J., Collin J. P. Molecular and cellular aspects of hydroxyindole-O-methyltransferase expression in the developing chick pineal gland. Dev. Brain Res. 59:1991;75-81.
19. Bernard M., Guerlotte J., Cogne M., Greve P., Collin J. P., Voisin P. Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland: day/night changes and long-term effects of light and darkness. Biochem. J. 290:1993;661-664.
20. Bernard M., Klein D. C., Zatz M. Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture. Proc. natl Acad. Sci. USA. 94:1997;304-309.
21. Bernard M., Iuvone P. M., Cassone V. M., Roseboom P. H., Coon S. L., Klein D. C. Avian melatonin synthesis: photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina. J. Neurochem. 68:1997;213-224.
22. Bégay V., Falcón J., Thibault C., Ravault J. P., Collin J. P. Pineal photoreceptor cells in culture: photoperiodic control of melatonin production after cell dissociation and culture. J. Neuroendocrinol. 4:1992;337-345.
23. Bégay V., Bois P., Collin J. P., Lenfant J., Falcón J. Calcium and melatonin production in dissociated trout pineal photoreceptor cells in culture. Cell Calcium. 16:1994;37-46.
24. Bégay V., Collin J. P., Falcón J. Calciproteins regulate cyclic AMP content and melatonin secretion in trout pineal photoreceptors. Neuroreport. 5:1994;2019-2022.
25. Bégay V., Valotaire Y., Ravault J. P., Collin J. P., Falcón J. Detection of estrogen receptor mRNA in trout pineal and retina: estradiol-17 beta modulates melatonin production by cultured pineal photoreceptor cells. Gen. Comp. Endocrinol. 93:1994;61-69.
26. Bégay V., Falcón J., Cahill G. M., Klein D. C., Coon S. L. Transcripts encoding two melatonin synthesis enzymes in the teleost pineal organ: circadian regulation in pike and zebrafish, but not in trout. Endocrinology. 139:1998;905-912.
27. Binkley S. A. Comparative biochemistry of the pineal gland of birds and mammals. Am. Zool. 16:1976;57-65.
28. Binkley S. A timekeeping enzyme in the pineal gland. Sci. Am. 240:1979;66-71.
29. Binkley S. A. Circadian rhythm of pineal function in rats. Endocrine Rev. 4(3):1983;255-270.
30. Binkley, S. A. (1986) Melatonin and N-acetyltransferase rhythms in pineal and retina. In: Pineal and Retinal Relationships, pp. 185-196. Eds. P. J. O'Brien and D. C. Klein. Academic Press, New York.
31. Binkley, S. (1988) The Pineal, Endocrine and Neuroendocrine Function, pp. 1-305. Prentice Hall, New Jersey.
32. Binkley S. A., Geller E. Pineal enzymes in chicken: development of daily rhythmicity. Gen. Comp. Endocrinol. 27(4):1975;427-429.
33. Binkley S., Riebman J. B., Reilly K. B. Timekeeping by the pineal gland. Science. 197:1977;1181-1183.
34. Binkley S. A., Riebman J. B., Reilly K. B. The pineal gland: a biological clock in vitro. Science. 202:1978;1198-1200.
35. Binkley S., Muller G., Hernandez T. Circadian rhythm in pineal N-acetyltransferase activity: phase shifting by light pulses (I). J. Neurochem. 37:1981;798-800.
36. Bittman E. L., Dempsey R. J., Karsch F. J. Pineal melatonin secretion drives the reproductive response to daylength in the ewe. Endocrinology. 113:1983;2276-2283.
37. Blackshaw S., Snyder S. H. Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function. J. Neurosci. 17:1997;8074-8082.
38. Blazinsky C., Cohen A. I. Rapid declines in cyclic GMP of rod outer segments of intact frog photoreceptors after illumination. J. Biol. Chem. 261:1986;14142-14147.
39. Boers G. J. Neurotransplantation of the biological clock in mammals, importance and perspectives. Biol. Rhythm Res. 28:1997;272-282.
40. Bolliet V., Ali M. A., Anctil M., Zachmann A. Melatonin secretion in vitro from the pineal complex of the lamprey Petromyzon marinus. Gen. Comp. Endocrinol. 89:1993;101-106.
41. Bolliet V., Bégay V., Ravault J. P., Ali M. A., Collin J. P., Falcón J. Multiple circadian oscillators in the photosensitive pike pineal gland: a study using organ and cell culture. J. Pineal Res. 16:1994;77-84.
42. Bolliet V., Falcón J., Ali M. A. Regulation of melatonin secretion by light in the isolated pineal organ of the white sucker (Catostomus commersoni). J. Neuroendocrinol. 7:1995;535-542.
43. Bolliet V., Ali M. A., Lapointe F. J., Falcón J. Rhythmic melatonin secretion in different teleost species: an in vitro study. J. Comp. Physiol. [B]. 165:1996;677-683.
44. Bolliet V., Bégay V., Taragnat C., Ravault J. P., Collin J. P., Falcón J. Photoreceptor cells of the pike pineal organ as cellular circadian oscillators. Eur. J. Neurosci. 9:1997;643-653.
45. Borjigin J., Wang M. M., Snyder S. H. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Nature. 378:1995;783-785.
46. Boya J., Calvo J. Post-hatching evolution of the pineal gland of the chicken. Acta Anat. (Basel). 101:1978;1-9.
47. Cahill G. M. Circadian regulation of melatonin production in cultured zebrafish pineal and retina. Brain Res. 708:1996;177-181.
48. Cahill G. M. Circadian melatonin rhythms in cultured zebrafish pineals are not affected by catecholamine receptor agonists. Gen. Comp. Endocrinol. 105:1997;270-275.
49. Cahill G. M., Besharse J. C. Retinal melatonin is metabolized within the eye of xenopus laevis. Proc. natl Acad. Sci. USA. 86:1989;1098-1102.
50. Cahill G. M., Besharse J. C. Circadian clock functions localized in xenopus retinal photoreceptors. Neuron. 10:1993;573-577.
51. Cahill G. M., Besharse J. C. Circadian rhythmicity in vertebrate retinas: regulation by photoreceptor oscillations. Prog. Ret. Eye Res. 14:1995;267-291.
52. Cahill G. M., Grace M. S., Besharse J. C. Rhythmic regulation of retinal melatonin: metabolic pathways, neurochemical mechanisms, and the ocular circadian clock. Cell. Molec. Neurobiol. 11:1991;529-560.
53. Calvo J., Boya J. Ultrastructural study of the embryonic development of the pineal gland of the chicken (Gallus gallus). Acta anat. 103:1979;39-73.
54. Cassone V. M., Menaker M. Sympathetic regulation of chicken pineal rhythms. Brain Res. 272:1983;311-317.
55. Cassone V. M., Takahashi J. S., Blaha C. D., Lane R. F., Menaker M. Dynamics of noradrenergic circadian input to the chicken pineal gland. Brain Res. 384:1986;334-341.
56. 14C]glucose uptake within rat suprachiasmatic nucleus. Am. J. Physiol. 255:1988;332-337.
57. Cassone V. M., Forsyth A. M., Woodlee G. L. Hypothalamic regulation of circadian noradrenergic input to the chick pineal gland. J. Comp. Physiol. [A]. 167:1990;187-192.
58. Cassone V. M., Warren W. S., Brooks D. S., Lu J. Melatonin, the pineal gland, and circadian rhythms. J. Biol. Rhythms. 8:1993;73-81.
59. Cheng Y., Hardin P. E. Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling. J. Neurosci. 18:1998;741-750.
60. Clabough J. W. Cytological aspects of pineal development in rats and hamsters. Am. J. Anat. 137:1973;215-229.
61. Cockrem J. F., Follet B. K. Circadian rhythm of melatonin in the pineal gland of the Japanese quail (Coturnix coturnix japonica). J. Endocrinol. 107:1985;317-324.
62. Cogburn L. A., Wilson-Placentra S., Letcher L. R. Influence of pinealectomy on plasma and extrapineal melatonin rhythms in young chickens (Gallus domesticus). Gen. Comp. Endocrinol. 68:1987;343-356.
63. Collin, J. P. (1971) Differentiation and regression of the cells of the sensory line in the epiphysis cerebri. In: The Pineal Gland, pp. 79-120. Eds. G. E. W. Wolstenholme and J. Knight. Churchill Livingstone, London.
64. Collin J. P., Juillard M. T. Membranous sites of oxidative deamination: a comparison between ultracytochemical and radioautographic studies in the pineal organ of the wall lizard and the parakeet. Biol. Cell. 36:1979;29-35.
65. Collin, J. P. and Oksche, A. (1981) Structural and functionnal relationships in the nonmammalian pineal organ. In: The pineal gland. Volume I. Anatomy and biochemistry, pp. 27-67. Ed. R. J. Reiter. CRC Press, Boca Raton.
66. Collin, J. P., Brisson, P., Falcón, J. and Voisin, P. (1986a) Multiple cell types in the pineal: functional aspects. In: Pineal and Retinal Relationships, pp. 15-32. Eds. P. J. O'Brien and D. C. Klein. Academic Press, Orlando.
67. Collin J. P., Mirshahi M., Brisson P., Falcón J., Guerlotté J., Faure J. P. Pineal-retinal molecular relationships: distribution of "S-antigen" in the pineal complex. Neuroscience. 19:1986;657-666.
68. Collin J. P., Voisin P., Falcón J., Faure J. P., Brisson P., Defaye J. R. Pineal transducers in the course of evolution: molecular organisation, rhythmic metabolic activity and role. Arch. Histol. Cytol. 52:1989;441-449.
69. Coon S. L., Roseboom P. H., Baler R., Weller J. L., Namboodiri M. A., Koonin E. V., Klein D. C. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science. 270:1995;1681-1683.
70. Coon S. L., Mazuruk K., Bernard M., Roseboom P. H., Klein D. C., Rodriguez I. R. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics. 34:1996;76-84.
71. Cosci B., Longoni B., Marchiafava P. L. Melatonin induces membrane conductance changes in isolated retinal rod receptor cells. Life Sci. 60:1997;1885-1889.
72. Crosthwaite S. K., Dunlap J. C., Loros J. J. Neurospora wc-1 and wc-2: transcription, photoresponses, and the origins of circadian rhythmicity. Science. 276:1997;763-769.
73. d'Istria M., Monteleone P., Serino I., Chieffi G. Seasonal variations in the daily rhythm of melatonin and NAT activity in the Harderian gland, retina, pineal gland, and serum of the green frog, Rana esculenta. Gen. Comp. Endocrinol. 96:1994;6-11.
74. D'Souza T., Dryer S. E. Intracellular free Ca2+ in dissociated cells of the chick pineal gland: regulation by membrane depolarization, second messengers and neuromodulators, and evidence for release of intracellular Ca2+ stores. Brain Res. 656:1994;85-94.
75. D'Souza T., Dryer S. E. Effects of phosphodiesterase inhibitors and forskolin on cyclic GMP-activated channels in intact isolated cells of the chick pineal gland. Neurochem. Int. 27:1995;527-533.
76. D'Souza T., Dryer S. E. A cationic channel regulated by a vertebrate intrinsic circadian oscillator. Nature. 382:1996;165-167.
77. Darlington T. K., Wager-Smith K., Ceriani M. F., Staknis D., Gekakis N., Steeves T. D. L., Weitz C. J., Takahashi J. S., Kay S. A. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science. 280:1998;1599-1603.
78. Deguchi T. A circadian oscillator in cultured cells of chicken pineal gland. Nature. 282:1979;94-96.
79. Deguchi T. Rhodopsin-like photosensitivity of isolated chicken pineal gland. Nature. 290:1981;706-707.
80. Donohue S. J., Roseboom P. H., Illnerova H., Weller J. L., Klein D. C. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. DNA Cell Biol. 12:1993;715-727.
81. Dryer S. E., Henderson D. A cyclic GMP-activated channel in dissociated cells of the chick pineal gland. Nature. 353:1991;756-758.
82. Dryer S. E., Henderson D. Cyclic GMP-activated channels of the chick pineal gland: effects of divalent cations, pH, and cyclic AMP. J. Comp. Physiol. [A]. 172:1993;271-279.
83. Dubocovich, M. (1986) Modulation of dopaminergic activity by melatonin in retina. In: Pineal-Retinal relationships, Eds P. J. O'Brien and D. C. Klein (Eds.), pp. 239-252. Academic Press, Orlando.
84. Ebihara S., Ushiyama K., Oshima I. Circadian organization in the pigeon, Columbia livia: the role of the pineal organ and the eye. J. Comp. Physiol. [A]. 154:1984;59-69.
85. Edmunds, L. N. (1988) Cellular and Molecular Basis of Biological Clocks: Models and Mechanisms for Biological Timekeeping. Springer Verlag, Berlin.
86. Edmunds L. N. Clocks, cell cycles, cancer, and aging. Role of the adenylate cyclase-cyclic AMP-phosphodiesterase axis in signal transduction between circadian oscillator and cell division cycle. Ann. N. Y. Acad. Sci. 719:1994;77-96.
87. Ekström P. Central neural connections of the pineal organ and retina in the teleost Gasterosteus aculeatus L. J. Comp. Neurol. 226:1984;321-335.
88. Ekström P., Meissl H. Electron microscopic analysis of S-antigen- and serotonin-immunoreactive neural and sensory elements in the photosensory pineal organ of the salmon. J. Comp. Neurol. 292:1990;73-82.
89. Ekström P., Meissl H. The pineal organ of teleost fishes. Rev. Fish Biol. Fish. 7:1997;199-284.
90. Ekström P., Foster R. G., Korf H. W., Schalken J. J. Antibodies against retinal photoreceptor-specific proteins reveal axonal projections from the photosensory pineal organ in teleosts. J. Comp. Neurol. 265:1987;25-33.
91. Ekström P., Ostholm T., Meissl H., Bruun A., Richards J. G., Mohler H. Neural elements in the pineal complex of the frog, Rana esculenta, II: GABA-immunoreactive neurons and FMRFamide-immunoreactive efferent axons. Vis. Neurosci. 4:1990;399-412.
92. Eskin A., Takahashi J. S. Adenylate cyclase activation shifts the phase of a circadian pacemaker. Science. 220:1983;82-84.
93. Eskin A., Takahashi J. S., Zatz M., Block G. D. Cyclic guanosine 3′:5′-monophosphate mimics the effects of light on a circadian pacemaker in the eye of aplysia. J. Neurosci. 4:1984;2466-2471.
94. Falcón J., Collin J. P. Photoreceptors in the pineal of lower vertebrates: functional aspects. Experientia. 45:1989;909-913.
95. Falcón J., Collin J. P. Pineal-retinal relationships: rhythmic biosynthesis and immunocytochemical localization of melatonin in the retina of the pike (Esox lucius L.). Cell Tissue Res. 265:1991;601-609.
96. Falcón J., Gaildrat P. Variations in cyclic adenosine 3′,5′-monophosphate and cyclic guanosine 3′,5′-monophosphate content and efflux from the photosensitive pineal organ of the pike in culture. Pflugers Arch. 433:1997;336-342.
97. Falcón J., Mocquard J. P. L'organe pinéal du Brochet (Esox lucius, L.): voies intrapinéales de conduction des messages photosensoriels. Ann. Biol. anim. Biochim. Biophys. 19:1979;1043-1061.
98. Falcón J., Tanabe J. Early receptor potential of pineal organ and lateral eye of the pike. Naturwissenschaften. 70:1983;149-150.
99. Falcón J., Juillard M. T., Collin J. P. The pineal organ of the pike (Esox lucius L.). IV. Endogenous serotonin and monoamine oxidase activity: an histochemical, ultracytochemical and pharmacological study. Reprod. Nutr. Dev. 20:1980;139-154.
100. Falcón J., Geffard M., Juillard M. T., Delaage, Collin J. P. Melatonin-like immunoreactivity in photoreceptor cells: a study in the teleost pineal organ and the concept of photoneuroendocrine cells. Biol. Cell. 42:1981;65-68.
101. Falcón J., Geffard M., Juillard M. T., Steinbusch H. W., Séguela P., Collin J. P. Immunocytochemical localization and circadian variations of serotonin and N-acetylserotonin in photoreceptor cells. Light and electron microscopic study in the teleost pineal organ. J. Histochem. Cytochem. 32:1984;486-492.
102. 3H]indole compounds in the pineal organ of the pike II. A radioautographic study. J. Pineal Res. 2:1985;357-373.
103. Falcón J., Guerlotté J., Voisin P., Collin J. P. Rhythmic melatonin biosynthesis in a photoreceptive pineal organ: a study in the pike. Neuroendocrinology. 45:1987;479-486.
104. Falcón J., Brun-Marmillon J., Claustrat B., Collin J. P. Melatonin production in organ cultured chicken pineal: modulation by adenosine and its analogs. Pflugers Arch. 413:1988;93-95.
105. Falcón J., Marmillon J. B., Claustrat B., Collin J. P. Regulation of melatonin secretion in a photoreceptive pineal organ: an in vitro study in the pike. J. Neurosci. 9:1989;1943-1950.
106. Falcón J., Thibault C., Blazquez J. L., Vaudry H., Lin N., Collin J. P. Atrial natriuretic factor increases cyclic GMP and cyclic AMP levels in a directly photosensitive fish pineal organ. Pflügers Arch. (Eur. J. Physiol.). 417:1990;243-245.
107. Falcón J., Thibault C., Martin C., Brun-Marmillon J., Claustrat B., Collin J. P. Regulation of melatonin production by catecholamines and adenosine in a photoreceptive pineal organ. An in vitro study in the pike and the trout. J. Pineal Res. 11:1991;123-134.
108. Falcón, J., Thibault, C., Bégay, V., Zachmann, A. and Collin, J. P. (1992a) Regulation of the rhythmic melatonin secretion by the fish pineal photoreceptor cells. In: Rhythms in Fishes, pp. 167-198. Ed. M. A. Ali. Plenum Press, New York.
109. Falcón J., Bégay V., Besse C., Ravault J. P., Collin J. P. Pineal photoreceptor cells in culture: fine structure and light control of cyclic nucleotide levels. J. Neuroendocrinol. 4:1992;641-651.
110. Falcón, J., Thibault, C., Bégay, V., Zachmann, A. and Collin, J. P. (1992c) Regulation of the rhythmic melatonin secretion by the fish pineal photoreceptor cells. In: Rhythms in Fishes, pp. 167-198. Ed. M. A. Ali. Plenum Press, New York.
111. Falcón J., Bégay V., Goujon J. M., Voisin P., Guerlotté J., Collin J. P. Immunocytochemical localisation of hydroxyindole-O-methyltransferase in pineal photoreceptor cells of several fish species. J. Comp. Neurol. 341:1994;559-566.
112. Falcón J., Bolliet V., Ravault J. P., Chesneau D., Ali M. A., Collin J. P. Rhythmic secretion of melatonin by the superfused pike pineal organ: thermo- and photoperiod interaction. Neuroendocrinology. 60:1994;535-543.
113. Falcón J., Van Camp G., Collin J. P. Adenosine A2 receptor-mediated stimulation of cyclic AMP in cultured chicken pineal cells. J. Pineal Res. 19:1995;72-78.
114. Firth B. T., Kennaway D. J. Melatonin content of the pineal, parietal eye and blood plasma of the lizard, Trachydosaurus rugosus: effect of constant and fluctuating temperature. Brain Res. 404:1987;313-318.
115. Foà A., Menaker M. Contribution of the pineal and retinae to the circadian rhythms of circulating melatonin in the pigeons. J. Comp. Physiol. 164:1988;25-30.
116. Foà A., Janik D., Minutini L. Circadian rhythms of plasma melatonin in the ruin lizard Podarcis sicula: effects of pinealectomy. J. Pineal Res. 12:1992;109-113.
117. Foulkes N. S., Borjigin J., Snyder S. H., Sassonecorsi P. Transcriptional control of circadian hormone synthesis via the CREM feedback loop. Proc. natl Acad. Sci. USA. 93(24):1996;14140-14145.
118. Foulkes N. S., Borjigin J., Snyder S. H., Sassone-Corsi P. Rhythmic transcription: the molecular basis of circadian melatonin synthesis. Trends. Neurosci. 20:1997;487-492.
119. Foulkes N. S., Whitmore D., Sassone-Corsi P. Rhythmic transcription: the molecular basis of circadian melatonin synthesis. Biol. Cell. 89:1997;487-494.
120. Garceau N. Y., Liu Y., Loros J. J., Dunlap J. C. Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell. 89:1997;469-476.
121. Gastel J. A., Roseboom P. H., Rinaldi P. A., Weller J. L., Klein D. C. Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science. 279:1998;1358-1360.
122. Gauer F., Masson-Pevet M., Skene D. J., Vivien-Roels B., Pevet P. Daily rhythms of melatonin binding sites in the rat pars tuberalis and suprachiasmatic nuclei; evidence for a regulation of melatonin receptors by melatonin itself. Neuroendocrinology. 57:1993;120-126.
123. Gekakis N., Staknis D., Nguyen H. B., Davis F. C., Wilsbacher L. D., King D. P., Takahashi J. S., Weitz C. J. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280:1998;1564-1569.
124. Gern, W. A. and Nervina, J. N. (1986) Melatonin in vertebrates: arguments for local functions and hormonal effects. In: Pineal-Retinal Relationships, pp. 119-131. Eds. P. J. O'Brien and D. C. Klein. Academic Press, Orlando.
125. Gern W. A., Greenhouse S. S. Examination of in vitro melatonin secretion from superfused trout (Salmo gairdneri) pineal organs maintained under diel illumination or continuous darkness. Gen. Comp. Endocrinol. 71:1988;163-174.
126. Gern W. A., Ralph C. L. Melatonin synthesis by the retina. Science. 204:1979;183-184.
127. Gern W. A., Owens D. W., Ralph C. L. Plasma melatonin in the trout: day-night change demonstrated by radioimmunoassay. Gen. Comp. Endocrinol. 34:1978;453-458.
128. Gern W. A., Owens D. W., Ralph C. L. Persistence of the nycthemeral rhythm of melatonin secretion in pinealectomized or optic tract-sectioned trout. J. Exp. Zool. 206:1978;371-376.
129. Gern W. A., Owens D. W., Ralph C. L. The synthesis of melatonin by the trout retina. J. Exp. Zool. 206:1978;263-270.
130. Gern W. A., Wechsler E., Duvall D. Characteristics and non-rhythmicity of retinal hydroxyindole-O-methyltransferase activity in trout (Salmo gairdneri). Gen. Comp. Endocrinol. 53:1984;169-178.
131. Gillette, M. U., Medanic, M., McArthur, A. J., Liu, C., Ding, J. M., Faiman, L. E., Weber, E. T., Tcheng, T. and Gallman, E. A. (1995) Intrinsic neuronal rhythms in the suprachiasmatic nuclei and their adjustment. In: Anonymous Circadian Clocks and their Adjustment, pp. 134-153. Wiley, Chichester.
132. Grace M. S., Besharse J. C. Melatonin deacetylase activity in the pineal gland and brain of the lizards Anolis carolinensis and Sceloporus jarrovi. Neuroscience. 62:1994;615-623.
133. Grady R. K. Jr., Caliguri A., Mefford I. N. Day/night differences in pineal indoles in the adult pigeon (Columba livia). Comp. Biochem. Physiol. [C]. 78:1984;141-143.
134. Green C. B., Besharse J. C., Zatz M. Tryptophan hydroxylase mRNA levels are regulated by the circadian clock, temperature, and cAMP in chick pineal cells. Brain Res. 738:1996;1-7.
135. Grève P., Bernard M., Voisin P., Cogné M., Collin J. P., Guerlotté J. Cellular localization of hydroxyindole-O-methyltransferase mRNA in the chicken pineal gland. Neuroreport. 4:1993;803-806.
136. Grève P., Voisin P., Gréchez-Cassiau A., Bernard M., Collin J. P., Guerlotté J. Circadian regulation of hydroxyindole-O-methyltransferase mRNA in the chicken pineal gland in vivo and in vitro. Biochem. J. 319:1996;761-766.
137. Gréchez-Cassiau A., Grève P., Guerlotté J., Collin J. P., Voisin P. Hydroxyindole-O-methyltransferase gene expression in the pineal gland of chicken embryo: development of messenger RNA levels and regulation by serum. Brain Res. Dev. Brain Res. 88:1995;204-211.
138. Guerlotté J., Falcón J., Voisin P., Collin J. P. Indoles in the photoreceptor cells of the lamprey pineal complex. Ann. Endocrinol. (Paris). 47:1986;62-64.
139. Guerlotté J., Voisin P., Brisson P., Faure J. P., Collin J. P. Synthesis of melatonin by the pineal modified photoreceptors of birds immunocytochemical localization of hydroxyindole-O-methyltransferase. Biol. Cell. 64:1988;93-96.
140. Gwinner E., Benzinger I. Synchronization of a circadian rhythm in pinealectomized european starlings by daily injections of melatonin. J. Comp. Physiol. 127:1978;209-213.
141. Gwinner E., Hau M., Heigl S. Melatonin: generation and modulation of avian circadian rhythms. Brain Res. Bull. 44:1997;439-444.
142. Hall J. C. Tripping along the trail to the molecular mechanisms of biological clocks. Trends. Neurosci. 18:1995;230-240.
143. Hamasaki, D. I. and Eder, D. J. (1977) Adaptative radiation of the pineal system. In: Handbook of Sensory Physiology, Vol. VII/5. The Visual System in Vertebrates, pp. 497-548. Ed. F. Crescitelli. Springer verlag, Berlin.
144. Hamm H., Takahashi J. S., Menaker M. Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina. Brain Res. 266:1983;287-293.
145. Hasegawa M., Ebihara S. Circadian rhythms of pineal melatonin release in the pigeon measured by in vivo microdialysis. Neurosci. Lett. 148:1992;89-92.
146. Herbuté S., Bayle J. D. Multiple-unit activity in the pineal gland of the Japanese quail: spontaneous firing and responses to photic stimulations. Neuroendocrinology. 16:1974;52-64.
147. Herbuté S., Bayle J. D. Suppression of pineal multiunit response to flash after habenular lesion in quail. Am. J. Physiol. 233:1977;E293-7.
148. Hirunagi K., Ebihara S., Okano T., Takanaka Y., Fukada Y. Immunoelectron-microscopic investigation of the subcellular localization of pinopsin in the pineal organ of the chicken. Cell Tissue Res. 289:1997;235-241.
149. Iigo M., Aida K. Effects of season, temperature, and photoperiod on plasma melatonin rhythms in the goldfish, Carassius auratus. J. Pineal Res. 18:1995;62-68.
150. Iigo M., Kezuka H., Aida K., Hanyu I. Circadian rhythms of melatonin secretion from superfused goldfish (Carassius auratus) pineal glands in vitro. Gen. Comp. Endocrinol. 83:1991;152-158.
151. Iigo M., Furukawa K., Hattori A., Ohtani-Kaneko R., Hara M., Suzuki T., Tabata M., Aida K. Ocular melatonin rhythms in the goldfish, Carassius auratus. J. Biol. Rhythms. 12:1997;182-192.
152. Illnerova H., Vanecek J., Hoffmann K. Different mechanisms of phase delays and phase advances of the circadian rhythm in rat pineal N-acetyltransferase activity. J. Biol. Rhythms. 4:1989;187-200.
153. Ishida I., Ohsako S., Nakane M., Deguchi T. Expression and characterization of hydroxyindole O-methyltransferase from a cloned cDNA in Chinese hamster ovary cells. Brain Res. 388:1987;185-189.
154. Iuvone, P. M. (1986) Rhythms of melatonin biosynthesis in retina: involvement of calcium, cyclic AMP and dopamine in the regulation of serotonin N-acetyltransferase. In: Pineal and Retinal Relationships, pp. 197-218. Eds. P. J. O'Brien and D. C. Klein. Academic Press, Orlando.
155. Johnson, C. H. (1993) Phase response curves: what do they tell us about circadian rhythm. In: Circadian Clocks from Cells to Humans, pp. 209-247. Eds. T. Hiroshigue and K. Honna. Hokkaïdo University Press, Tokyo.
156. Jojich L., Pourcho R. G. Glutamate immunoreactivity in the cat retina: a quantitative study. Vis. Neurosci. 13:1996;117-133.
157. Kasal C. A., Menaker M., Perez-Polo J. R. Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro. Science. 203:1979;656-658.
158. Kezuka H., Furukawa K., Aida K., Hanyu I. Daily cycles in plasma melatonin levels under long or short photoperiod in the common carp, Cyprinus carpio. Gen. Comp. Endocrinol. 72:1988;296-302.
159. Kezuka H., Aida K., Hanyu I. Melatonin secretion from goldfish pineal gland in organ culture. Gen. Comp. Endocrinol. 75:1989;217-221.
160. Kezuka H., Iigo M., Furukawa K., Aida K., Hanyu I. Effects of photoperiod, pinealectomy and ophthalmectomy on circulating melatonin rhythms in the goldfish, Carassius auratus. Zool. Sci. 9:1992;1047-1053.
161. Khalsa S. B., Whitmore D., Block G. D. Stopping the circadian pacemaker with inhibitors of protein synthesis. Proc. natl Acad. Sci. USA. 89:1992;10862-10866.
162. Khalsa S. B., Whitmore D., Bogart B., Block G. D. Evidence for a central role of transcription in the timing mechanism of a circadian clock. Am. J. Physiol. 271:1996;C1646-51.
163. King D. P., Zhao Y., Sangoram A. M., Wilsbacher L. D., Tanaka M., Antoch M. P., Steeves T. D., Vitaterna M. H., Kornhauser J. M., Lowrey P. L., Turek F. W., Takahashi J. S. Positional cloning of the mouse circadian clock gene. Cell. 89:1997;641-653.
164. Klein D. C. Photoneural regulation of the mammalian pineal gland. Ciba Found. Symp. 117:1985;38-56.
165. Klein D. C., Moore R. Y. Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus. Brain Res. 174:1979;245-262.
166. Klein D. C., Weller J. L. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science. 169:1970;1093-1095.
167. Klein D. C., Weller J. L. Rapid light-induced decrease in pineal serotonin N-acetyltransferase activity. Science. 177:1972;532-533.
168. Klein, D. C., Auerbach, D. A., Namboodiri, M. A. and Wheler, G. H. T. (1981) Indole metabolism in the mammalian pineal gland. In: The Pineal Gland, pp. 199-227. Ed. R. J. Reiter. CRC Press, Boca Raton.
169. Klein D. C., Coon S. L., Roseboom P. H., Weller J. L., Bernard M., Gastel J. A., Zatz M., Iuvone P. M., Rodriguez I. R., Bégay V., Falcón J., Cahill G. M., Cassone V. M., Baler R. The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent. Prog. Horm. Res. 52:1997;307-357.
170. Korf B., Rollag M. D., Korf H. W. Ontogenetic development of S-antigen- and rod-opsin immunoreactions in retinal and pineal photoreceptors of Xenopus laevis in relation to the onset of melatonin-dependent color-change mechanisms. Cell Tissue Res. 258:1989;319-329.
171. Korf H. W., White B. H., Schaad N. C., Klein D. C. Recoverin in pineal organs and retinae of various vertebrate species including man. Brain Res. 595:1992;57-66.
172. Korf H. W., Schomerus C., Maronde E., Stehle J. H. Signal transduction molecules in the rat pineal organ: Ca2+, pCREB, and ICER. Naturwissenschaften. 83:1996;535-543.
173. Kramm C. M., de Grip W. J., Korf H. W. Rod-opsin immunoreaction in the pineal organ of the pigmented mouse does not indicate the presence of a functional photopigment. Cell Tissue Res. 274:1993;71-78.
174. Kroeber S., Schomerus C., Korf H. W. Calcium oscillations in a subpopulation of S-antigen- immunoreactive pinealocytes of the rainbow trout (Oncorhynchus mykiss). Brain Res. 744:1997;68-76.
175. Kuwano R., Iwanaga T., Nakajima T., Masuda T., Takahashi Y. Immunocytochemical demonstration of hydroxyindole O-methyltransferase (HIOMT), neuron-specific enolase (NSE) and S-100 protein in the bovine pineal gland. Brain Res. 274:1983;171-175.
176. Lakhdar-Ghazal N., Vivien-Roels B., Pevet P. Seasonal variations in pineal 5-methoxytryptophol (5-ML) concentrations and in the daily pattern of pineal 5-ML and melatonin in the desert rodent Jaculus orientalis: effect of prolonged illumination during the night. J. Pineal Res. 13:1992;28-35.
177. Lee C., Parikh V., Itsukaichi T., Bae K., Edery I. Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science. 271:1996;1740-1744.
178. Lee J. H., Hung C. F., Ho C. C., Chang S. H., Lai Y. S., Chung J. G. Light-induced changes in frog pineal gland N-acetyltransferase activity. Neurochem. Int. 31:1997;533-540.
179. Lewy A. J., Tetsuo M., Markey S. P., Goodwin F. K., Kopin I. J. Pinealectomy abolishes plasma melatonin in the rat. J. Clin. Endocrinol. Metab. 50:1980;204-205.
180. Liebmann P. M., Wolfler A., Felsner P., Hofer D., Schauenstein K. Melatonin and the immune system. Int. Arch. Allergy Immunol. 112:1997;203-211.
181. Liou S. S., Cogburn L. A., Biellier H. V. Photoperiodic regulation of plasma melatonin levels in the laying chicken (Gallus domesticus). Gen. Comp. Endocrinol. 67:1987;221-226.
182. Liu Y., Garceau N. Y., Loros J. J., Dunlap J. C. Thermally regulated translational control of FRQ mediates aspects of temperature responses in the neurospora circadian clock. Cell. 89:1997;477-486.
183. Martin C., Meissl H. Characterization of the light response in the pineal gland of intact and sympathectomized rats. J. Neural Transm. Gen. Sect. 79:1990;81-91.
184. Martin C., Meissl H. Effects of dopaminergic and noradrenergic mechanisms on the neuronal activity of the isolated pineal organ of the trout, Oncorhynchus mykiss. J. Neural Transm. Gen. Sect. 88:1992;37-51.
185. Martin C., Falcón J., Collin J. P. Catecholamines regulate cAMP levels in the photosensitive trout pineal organ. Adv. Pin. Res. 5:1991;137-140.
186. Max M., Menaker M. Regulation of melatonin production by light, darkness, and temperature in the trout pineal. J. Comp. Physiol. [A]. 170:1992;479-489.
187. Max M., McKinnon P. J., Seidenman K. J., Barrett R. K., Applebury M. L., Takahashi J. S., Margolskee R. F. Pineal opsin: a nonvisual opsin expressed in chick pineal. Science. 267:1995;1502-1506.
188. McArthur A. J., Gillette M. U., Prosser R. A. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res. 565:1991;158-161.
189. McNulty J. A. Functional morphology of the pineal complex in cyclostomes, elasmobranchs and bony fishes. Pin. Res. Rev. 2:1984;1-40.
190. Meiniel A. L'épiphyse embryonnaire de Lacerta vivipara J. I. Différenciation des cellules de la lignée sensorielle (CLS). Le gradient morphologique. J. Neural Transm. 39:1976;139-174.
191. Meissl, H. (1986) Photoneurophysiology of pinealocytes. In: Pineal and Retinal Relationships, pp. 33-45. Eds. P. J. O'Brien and D. C. Klein. Academic Press, Orlando.
192. Meissl, H. and Dodt, E. (1981) Comparative physiology of pineal photoreceptor organs. In: The Pineal Organ: Photobiology-Biochronometry-Endocrinology, pp. 61-80. Eds. A. Oksche and P. Pévet. Elsevier, Amsterdam.
193. Meissl H., George S. R. Photosensory properties of the pineal organ. Microiontophoretic application of excitatory amino acids onto pineal neurons. Ophthalmic Res. 16:1984;114-118.
194. Meissl H., George S. R. Electrophysiological studies on neuronal transmission in the frog's photosensory pineal organ. The effect of amino acids and biogenic amines. Vision Res. 24:1984;1727-1734.
195. Meissl H., Ekström P. Dark and light adaptation of pineal photoreceptors. Vision Res. 28:1988;49-56.
196. Meissl H., Ekström P. Photoreceptor responses to light in the isolated pineal organ of the trout, Salmo gairdneri. Neuroscience. 25:1988;1071-1076.
197. Meissl H., Kroeber S., Yanez J., Korf H. W. Regulation of melatonin production and intracellular calcium concentrations in the trout pineal organ. Cell Tissue Res. 286:1996;315-323.
198. Menaker M., Wisner S. Temperature-compensated circadian clock in the pineal of Anolis. Proc. natl Acad. Sci. USA. 80:1983;6119-6121.
199. Mendonça M. T., Tousignant A. J., Crews D. Seasonal changes and annual variability in daily plasma melatonin in the red-sided garter snake (Thamnophis sirtalis parietalis). Gen. Comp. Endocrinol. 100:1995;226-237.
200. Meunier A. C., Voisin P., Van Camp G., Cenatiempo Y., Muller J. M. Molecular characterization and peptide specificity of two vasoactive intestinal peptide (VIP) binding sites in the chicken pineal. Neuropeptides. 19:1991;1-8.
201. Miguez J. M., Recio J., Vivien-Roels B., Pevet P. Daily variation in the content of indoleamines, catecholamines and related compounds in the pineal gland of Syrian hamsters kept under long and short photoperiods. J. Pineal Res. 19:1995;139-148.
202. Miguez J. M., Recio J., Vivien-Roels B., Pevet P. Diurnal changes in the content of indoleamines, catecholamines, and methoxyindoles in the pineal gland of the Djungarian hamster (Phodopus sungorus): effect of photoperiod. J. Pineal Res. 21:1996;7-14.
203. Mirshahi M., Faure J. P., Brisson P., Falcón J., Guerlotté J., Collin J. S-antigen immunoreactivity in retinal rods and cones and pineal photosensitive cells. Biol. Cell. 52:1984;195-198.
204. Molina-Borja M., Falcón J., Urquiola E., Ravault J. P., Collin J. P. Production of melatonin by the seabream pineal: an in vivo and in vitro study. Fish Physiol. Biochem. 15:1996;413-419.
205. Moller, M. and van Veen, T. (1981) Fluorescence histochemistry of the pineal gland. In: The Pineal Gland. Volume I. Anatomy and Biochemistry, pp. 69-93, Ed. R. J. Reiter. CRC Press, Boca Raton.
206. Moller M., Ravault J. P., Cozzi B. The chemical neuroanatomy of the mammalian pineal gland: neuropeptides. Neurochem. Int. 28:1996;23-33.
207. Moore R. Y. Organization of the mammalian circadian system. Ciba Found. Symp. 183:1995;88-99.
208. Moore R. Y. Circadian rhythms: basic neurobiology and clinical applications. A. Rev. Med. 48:1997;253-266.
209. Morita Y. Absence of electrical activity of the pigeon's pineal organ in response to light. Experientia. 22:1966;402.
210. Morton D. J., Forbes H. J. Pineal gland N-acetyltransferase and hydroxyindole-O- methyltransferase activity in the rainbow trout (Salmo gairdneri): seasonal variation linked to photoperiod. Neurosci. Lett. 94:1988;333-337.
211. Moyer R. W., Firth B. T., Kennaway D. J. Effect of variable temperatures, darkness and light on the secretion of melatonin by pineal explants in the gecko, Christinus marmoratus. Brain Res. 747:1997;230-235.
212. Murakami N., Nakamura H., Nishi R., Marumoto N., Nasu T. Comparison of circadian oscillation of melatonin release in pineal cells of house sparrow, pigeon and Japanese quail, using cell perfusion systems. Brain Res. 651:1994;209-214.
213. Murakami N., Nishi R., Katayama T., Nasu T. Inhibitor of protein synthesis phase-shifts the circadian oscillator and inhibits the light induced-phase shift of the melatonin rhythm in pigeon pineal cells. Brain Res. 693:1995;1-7.
214. Myers M. P., Wager-Smith K., Rothenfluh-Hilfiker A., Young M. W. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science. 271:1996;1736-1740.
215. Nakahara K., Murakami N., Nasu T., Kuroda H., Murakami T. Individual pineal cells in chick possess photoreceptive, circadian clock and melatonin-synthesizing capacities in vitro. Brain Res. 774:1997;242-245.
216. Namboodiri M. A., Sugden D., Klein D. C., Grady R. Jr., Mefford I. N. Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: effects of cycloheximide. J. Neurochem. 45:1985;832-835.
217. Nikaido S. S., Takahashi J. S. Twenty-four hour oscillation of cAMP in chick pineal cells: role of cAMP in the acute and circadian regulation of melatonin production. Neuron. 3:1989;609-619.
218. Ohshima K., Matsuo S. Immunohistochemical localization of serotonin in the pineal gland of the chicken during post-hatching development in relation to light-dark cycle. Anat. Anz. 173:1991;65-72.
219. Okano T., Yoshizawa T., Fukada Y. Pinopsin is a chicken pineal photoreceptive molecule. Nature. 372:1994;94-97.
220. Okano T., Yamazaki K., Kasahara T., Fukada Y. Molecular cloning of heterotrimeric G-protein alpha-subunits in chicken pineal gland. J. Mol. Evol. 44:1997;91-97.
221. Okimoto, D. and Stetson, M. (1997) In vitro characterization of a circadian oscillator regulating pineal melatonin production in the sailfin molly, Poecilia velifera. Abstract book, Poitiers, 9-11 July, P4-3 p.
222. Oksche, A. (1971) Sensory and glandular elements of the pineal organ. In: The Pineal Gland, pp. 127-146. Eds. G. E. W. Wolstenholme and J. Knight. Churchill Livingstone, London.
223. Olcese J., Moller M. Characterization of serotonin N-acetyltransferase activity in the retina of the Mongolian gerbil, Meriones unguiculates. Neurosci. Lett. 102:1989;235-240.
224. Omura Y., Oguri M. Histological studies on the pineal organ of 15 species of teleost fishes. Bull. Jap. Soc. Fish. 35:1969;991-1000.
225. Oshima I., Yamada H., Goto M., Sato K., Ebihara S. Pineal and retinal melatonin is involved in the control of circadian locomotor activity and body temperature rhythms in the pigeon. J. Comp. Physiol. [A]. 166:1989;217-226.
226. Osol G., Schwartz B., Foss D. C. Effects of time, photoperiod, and pinealectomy on ocular and plasma melatonin concentrations in the chick. Gen. Comp. Endocrinol. 58:1985;415-420.
227. Palczewski K., Carruth M. E., Adamus G., McDowell J. H., Hargrave P. A. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 30:1990;1129-1137.
228. Pang S. F., Chow P. H., Wong T. M., Tso E. C. Diurnal variations of melatonin and N-acetylserotonin in the tissues of quails (Coturnix sp.), pigeons (Columba livia), and chickens (Gallus domesticus). Gen. Comp. Endocrinol. 51:1983;1-7.
229. Pévet P., Vivien-Roels B., Masson-Pevet M., Steinlechner S., Skene D., Canguilhem B. Melatonin, serotonin, 5-hydroxyindole-3-acetic acid and N- acetyltransferase in the pineal of the European hamster (Cricetus cricetus) kept under natural environmental conditions: lack of a day/night rhythm in melatonin formation in spring and early summer. J. Pineal Res. 6:1989;233-242.
230. Pickard G. E., Tang W. X. Individual pineal cells exhibit a circadian rhythm in melatonin secretion. Brain Res. 627:1993;141-146.
231. Pickard G. E., Tang W. X. Pineal photoreceptors rhythmically secrete melatonin. Neurosci. Lett. 171:1994;109-112.
232. Polans A., Baehr W., Palczewski K. Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends. Neurosci. 19:1996;547-554.
233. Pratt B. L., Takahashi J. S. Alpha-2 adrenergic regulation of melatonin release in chick pineal cell cultures. J. Neurosci. 7:1987;3665-3674.
234. Pratt B. L., Takahashi J. S. Vasoactive intestinal polypeptide and alpha 2-adrenoceptor agonists regulate adenosine 3′,5′-monophosphate accumulation and melatonin release in chick pineal cell cultures. Endocrinology. 125:1989;2375-2384.
235. Prosser R. A., Gillette M. U. Cyclic changes in cAMP concentration and phosphodiesterase activity in a mammalian circadian clock studied in vitro. Brain Res. 568:1991;185-192.
236. Prosser R. A., McArthur A. J., Gillette M. U. cGMP induces phase shifts of a mammalian circadian pacemaker at night, in antiphase to cAMP effects. Proc. natl Acad. Sci. USA. 86:1989;6812-6815.
237. Prosser R. A., Edgar D. M., Heller H. C., Miller J. D. A possible glial role in the mammalian circadian clock. Brain Res. 643:1994;296-301.
238. Pugh E. N. Jr., Lamb T. D. Cyclic GMP and calcium: the internal messengers of excitation and adaptation in vertebrate photoreceptors. Vision Res. 30:1990;1923-1948.
239. Pugh E. N. Jr., Lamb T. D. Amplification and kinetics of the activation steps in phototransduction. Biochim. Biophys. Acta. 1141:1993;111-149.
240. Quay W. B. Retinal and pineal hydroxyindole-O-methyl transferase activity in vertebrates. Life Sci. 4:1965;983-991.
241. Quay W. B. Rhythmic and light-induced changes in levels of pineal 5-hydroxyindoles in the pigeon (Columbia livia). Gen. Comp. Endocrinol. 6:1966;371-377.
242. Quay, W. B. (1974) Pineal Chemistry, pp. 1-430. Charles C. Thomas, Springfield.
243. Ralph C. L. Correlations of melatonin content in the pineal gland, blood and brain of some birds and mammals. Am. Zool. 16:1976;35-43.
244. Ralph C. L., Dawson D. C. Failure of the pineal body of 2 species of birds (Coturnix coturnix japonica and Passer domesticus) to show electrical responses to illumination. Experientia. 24:1968;147-148.
245. Ralph M. R., Menaker M. A mutation of the circadian system in golden hamsters. Science. 241:1988;1225-1227.
246. Ralph C. L., Mull D., Lynch H. J., Hedlund L. A melatonin rhythm persists in rat pineals in darkness. Endocrinology. 89:1971;1361-1366.
247. Ralph C. L., Pelham R. W., MacBride S. E., Reilly D. P. Persistent rhythms of pineal and serum melatonin in cockerels in continuous darkness. J. Endocrinol. 63:1974;319-324.
248. Ralph C. L., Binkley S., MacBride S. E., Klein D. C. Regulation of pineal rhythms in chickens: effects of blinding, constant light, constant dark, and superior cervical ganglionectomy. Endocrinology. 97:1975;1373-1378.
249. Randall C. F., Bromage N. R., Thorpe J. E., Miles M. S., Muir J. S. Melatonin rhythms in Atlantic salmon (Salmo salar) maintained under natural and out-of-phase photoperiods. Gen. Comp. Endocrinol. 98:1995;73-86.
250. Reiter, R. J. (1981) The pineal gland. Anatomy and biochemistry. In: Pineal Biochemistry: Comparative aspects and Circadian Rhythms, pp. 155-172. Ed. S. A. Binkley. CRC Press, Orlando.
251. Reiter R. J. Melatonin synthesis: multiplicity of regulation. Adv. Exp. Med. Biol. 294:1991;149-158.
252. Reiter R. J., Richardson B. A., Hurlbut E. C. Pineal, retinal and harderian gland melatonin in a diurnal species, the Rhicharson's ground squirrel. Neurosci. Lett. 22:1981;285-288.
253. Robertson L. M., Takahashi J. S. Circadian clock in cell culture: I. Oscillation of melatonin release from dissociated chick pineal cells in flow-through microcarrier culture. J. Neurosci. 8:1988;12-21.
254. Robertson L. M., Takahashi J. S. Circadian clock in cell culture: II. In vitro photic entrainment of melatonin oscillation from dissociated chick pineal cells. J. Neurosci. 8:1988;22-30.
255. Robinson J., Schmitt E. A., Dowling J. E. Temporal and spatial patterns of opsin gene expression in zebrafish (Danio rerio). Vis. Neurosci. 12:1995;895-906.
256. Roseboom P. H., Klein D. C. Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor/cyclic AMP mechanism. Mol. Pharmacol. 47:1995;439-449.
257. Roseboom P. H., Coon S. L., Baler R., McCune S. K., Weller J. L., Klein D. C. Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Endocrinology. 137:1996;3033-3045.
258. Samejima M., Morita Y. External sodium ions are required for the light response in pineal photoreceptors. Vision Res. 28:1988;251-258.
259. Sato T., Wake K. Innervation of the avian pineal organ. A comparative study. Cell Tissue Res. 233:1983;237-264.
260. Sato T., Deguchi T., Ichikawa T., Fujieda H., Wake K. Localization of hydroxyindole-O-methyltransferase-synthesizing cells in bovine epithalamus: immunocytochemistry and in-situ hybridization. Cell Tissue Res. 263:1991;413-418.
261. Schmitz Y., Witkovsky P. Dependence of photoreceptor glutamate release on a dihydropyridine-sensitive calcium channel. Neuroscience. 78:1997;1209-1216.
262. Schomerus C., Ruth P., Korf H. W. Photoreceptor-specific proteins in the mammalian pineal organ: immunocytochemical data and functional considerations. Acta Neurobiol. Exp. (Warsz). 54(Suppl.):1994;9-17.
263. Schomerus C., Maronde E., Laedtke E., Korf H. W. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) induce phosphorylation of the transcription factor CREB in subpopulations of rat pinealocytes: immunocytochemical and immunochemical evidence. Cell Tissue Res. 286:1996;305-313.
264. Sehgal A., Price J. L., Man B., Young M. W. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science. 263:1994;1603-1606.
265. Serino I., d'Istria M., Monteleone P. A comparative study of melatonin production in the retina, pineal gland and harderian gland of Bufo viridis and Rana esculenta. Comp. Biochem. Physiol. [C]. 106:1993;189-193.
266. Shigeyoshi Y., Taguchi K., Yamamoto S., Takekida S., Yan L., Tei H., Moriya T., Shibata S., Loros J. J., Dunlap J. C., Okamura H. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell. 91:1997;1043-1053.
267. Shinohara K., Honma S., Katsuno Y., Abe H., Honma K. Two distinct oscillators in the rat suprachiasmatic nucleus in vitro. Proc. natl Acad. Sci. USA. 92:1995;7396-7400.
268. Siwicki K. K., Eastman C., Petersen G., Rosbash M., Hall J. C. Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron. 1:1988;141-150.
269. Skene D. J., Pévet P., Vivien-Roels B., Masson-Pévet M., Arendt J. Effect of different photoperiods on concentrations of 5-methoxytryptophol and melatonin in the pineal gland of the Syrian hamster. J. Endocrinol. 114:1987;301-309.
270. Stehle J. H., Foulkes N. S., Molina C. A., Simonneaux V., Pévet P., Sassone-Corsi P. Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature. 365:1993;314-320.
271. Steinlechner S., Baumgartner I., Klante G., Reiter R. J. Melatonin synthesis in the retina and pineal gland of Djungarian hamsters at different times of the year. Neurochem. Int. 27:1995;245-251.
272. Sugden D. Melatonin biosynthesis in the mammalian pineal gland. Experientia. 45:1989;922-932.
273. Sun J. H., Reiter R. J., Mata N. L., Tsin A. T. Identification of 11-cis-retinal and demonstration of its light-induced isomerization in the chicken pineal gland. Neurosci. Lett. 133:1991;97-99.
274. Sun J. H., Reiter R. J., Hattori A., Yaga K., Herbert D. C., Tsin A. T. Phototransduction-related circadian changes in indoleamine metabolism in the chick pineal gland in vivo. J. Pineal Res. 15:1993;132-137.
275. Sun Z. S., Albrecht U., Zhuchenko O., Bailey J., Eichele G., Lee C. C. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell. 90:1997;1003-1011.
276. Takahashi J. S. Molecular neurobiology and genetics of circadian rhythms in mammals. A. Rev. Neurosci. 18:1995;531-553.
277. Takahashi J. S., Hamm H., Menaker M. Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. Proc. natl Acad. Sci. USA. 77:1980;2319-2322.
278. Takahashi J. S., Murakami N., Nikaido S. S., Pratt B. L., Robertson L. M. The avian pineal, a vertebrate model system of the circadian oscillator: cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis. Recent. Prog. Horm. Res. 45:1989;279-348.
279. Tamotsu S., Korf H. W., Morita Y., Oksche A. Immunocytochemical localization of serotonin and photoreceptor-specific proteins (rod-opsin, S-antigen) in the pineal complex of the river lamprey, Lampetra japonica, with special reference to photoneuroendocrine cells. Cell Tissue Res. 262:1990;205-216.
280. Tamotsu S., Schomerus C., Stehle J. H., Roseboom P. H., Korf H. W. Norepinephrine-induced phosphorylation of the transcription factor CREB in isolated rat pinealocytes: an immunocytochemical study. Cell Tissue Res. 282:1995;219-226.
281. Taniguchi M., Murakami N., Nakamura H., Nasu T., Shinohara S., Etoh T. Melatonin release from pineal cells of diurnal and nocturnal birds. Brain Res. 620:1993;297-300.
282. Thibault C., Falcón J., Greenhouse S. S., Lowery C. A., Gern W. A., Collin J. P. Regulation of melatonin production by pineal photoreceptor cells: role of cyclic nucleotides in the trout (Oncorhynchus mykiss). J. Neurochem. 61:1993;332-339.
283. Thibault, C., Collin, J. P. and Falcón, J. (1993b) Intrapineal circadian oscillator(s), cyclic nucleotides and melatonin production in pike pineal photoreceptor cells. In: Melatonin and the Pineal Gland: From Basic Science to Clinical Application, pp. 11-18. Ed. Y. Touitou. Elsevier, Amsterdam.
284. Torres G., Lytle L. D. Extraretinal mechanisms mediate light-induced changes in neonatal rat pineal gland N-acetyltransferase activity. J. Pineal Res. 7:1989;211-220.
285. Torres G., Lytle L. D. Light affects neonatal rat pineal gland N-acetyltransferase activity by an extra-retinal mechanism. J. Neural Transm. Gen. Sect. 80:1990;67-77.
286. Turek F. W. Circadian rhythms. Recent. Prog. Horm. Res. 49:1994;43-90.
287. Underwood H. Pineal melatonin rhythms in the lizard Anolis carolinensis: effects of light and temperature cycles. J. Comp. Physiol. [A]. 157:1985;57-65.
288. Underwood H. The pineal and melatonin: regulators of circadian function in lower vertebrates. Experientia. 45:1989;914-922.
289. Underwood H., Hyde The effect of daylength on the pineal melatonin rhythm of the lizard Anolis carolinensis. Comp. Biochem. Physiol. 94A:1989;53-56.
290. Underwood H., Binkley S., Siopes T., Mosher K. Melatonin rhythms in the eyes, pineal bodies, and blood of Japanese quail (Coturnix coturnix japonica). Gen. Comp. Endocrinol. 56:1984;70-81.
291. Vakkuri O., Rintamäki H., Leppäluoto J. Plasma and tissue concentrations of melatonin after midnight light exposure and pinealectomy in the pigeon. J. Endocrinol. 105:1985;263-268.
292. Van Camp G., Voisin P., Collin J. P. Mechanisms of the KCl-induced stimulation of serotonin N-acetyltransferase in chick pineal cells. Adv. Pineal Res. 5:1991;63.
293. Van't Hof T. J., Gwinner E. Development of post-hatching melatonin rhythm in zebra finches (Poephila guttata). Experientia. 52:1996;249-252.
294. van Veen T., Laxmyr L., Borg B. Diurnal variation of 5-hydroxytryptamine content in the pineal organ of the yellow eel (Anguilla anguilla (L.)). Gen. Comp. Endocrinol. 46:1982;322-326.
295. van Veen T., Ekström P., Nyberg L., Borg B., Vigh-Teichmann I., Vigh B. Serotonin and opsin immunoreactivities in the developing pineal organ of the three-spined stickleback, Gasterosteus aculeatus. L. Cell Tissue Res. 237:1984;559-564.
296. van Veen T., Vigh-Teichmann I., Vigh B., Hartwig H. G. Light and electron microscopy of S-antigen- and opsin-immunoreactive photoreceptors in the retina of turtle, chicken, and hedgehog. Exp. Biol. 45:1986;1-14.
297. Vigh B., Vigh-Teichmann I. Light- and electron-microscopic demonstration of immunoreactive opsin in the pinealocytes of various vertebrates. Cell Tissue Res. 221:1981;451-463.
298. Vigh B., Debreceni K., Manzano E. S. M. J. Similar localization of immunoreactive glutamate and aspartate in the pineal organ and retina of various nonmammalian vertebrates. Acta Biol. Hung. 46:1995;99-106.
299. Vigh B., Debreceni K., Fejeacuter Z., Vigh-Teichmann I. Immunoreactive excitatory amino acids in the parietal eye of lizards, a comparison with the pineal organ and retina. Cell Tissue Res. 287:1997;275-283.
300. Vigh-Teichmann I., Korf H. W., Nurnberger F., Oksche A., Vigh B., Olsson R. Opsin-immunoreactive outer segments in the pineal and parapineal organs of the lamprey (Lampetra fluviatilis), the eel (Anguilla anguilla), and the rainbow trout (Salmo gairdneri). Cell Tissue Res. 230:1983;289-307.
301. Vigh-Teichmann I., Vigh B., Szel A., Rohlich P., Wirtz G. H. Immunocytochemical localization of vitamin A in the retina and pineal organ of the frog, Rana esculenta. Histochemistry. 88:1988;533-543.
302. Viswanathan N., Davis F. C. Suprachiasmatic nucleus grafts restore circadian function in aged hamsters. Brain Res. 686:1995;10-16.
303. Vitaterna M. H., King D. P., Chang A. M., Kornhauser J. M., Lowrey P. L., McDonald J. D., Dove W. F., Pinto L. H., Turek F. W., Takahashi J. S. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 264:1994;719-725.
304. Vivien-Roels B., Pévet P. The pineal gland and the synchronization of reproductive cycles with variations of the environmental climatic conditions, with special reference to temperature. Pineal Res. Rev. 1:1983;91-143.
305. Vivien-Roels B., Arendt J., Bradtke J. Circadian and circannual fluctuations of pineal indoleamines (serotonin and melatonin) in Testudo hermanni Gmelin (Reptilia, Chelonia). I. Under natural conditions of photoperiod and temperature. Gen. Comp. Endocrinol. 37:1979;197-210.
306. Vivien-Roels B., Pevet P., Claustrat B. Pineal and circulating melatonin rhythms in the box turtle, Terrapene carolina triunguis: effect of photoperiod, light pulse, and environmental temperature. Gen. Comp. Endocrinol. 69:1988;163-173.
307. Vivien-Roels B., Pevet P., Masson-Pevet M., Canguilhem B. Seasonal variations in the daily rhythm of pineal gland and/or circulating melatonin and 5-methoxytryptophol concentrations in the European hamster, Cricetus cricetus. Gen. Comp. Endocrinol. 86:1992;239-247.
308. Vivien-Roels B., Pitrosky B., Zitouni M., Malan A., Canguilhem B., Bonn D., Pevet P. Environmental control of the seasonal variations in the daily pattern of melatonin synthesis in the European hamster, Cricetus cricetus. Gen. Comp. Endocrinol. 106:1997;85-94.
309. Voisin P., Collin J. P. Regulation of chicken pineal arylalkylamine-N-acetyltransferase by postsynaptic alpha 2-adrenergic receptors. Life Sci. 39:1986;2025-2032.
310. Voisin P., Guerlotte J., Collin J. P. An antiserum against chicken hydroxyindole-O-methyltransferase reacts with the enzyme from pineal gland and retina and labels pineal modified photoreceptors. Brain Res. 464:1988;53-61.
311. Vollrath, L. (1981) The Pineal Organ, VI/7, pp. 1-665. Springer Verlag, Berlin.
312. Vosshall L. B., Price J. L., Sehgal A., Saez L., Young M. W. Block in nuclear localization of period protein by a second clock mutation, timeless. Science. 263:1994;1606-1609.
313. Wainwright S. D. Diurnal cycles in serotonin acetyltransferase activity and cyclic GMP content of cultured chick pineal glands. Nature. 285:1980;478-480.
314. Wainwright S. D., Wainwright L. K. Chick pineal serotonin acetyltransferase: a diurnal cycle maintained in vitro and its regulation by light. Can. J. Biochem. 57:1979;700-709.
315. Wainwright S. D., Wainwright L. K. Regulation of the cycle in chick pineal serotonin N- acetyltransferase activity in vitro by light. J. Neurochem. 35:1980;451-457.
316. Wainwright S. D., Wainwright L. K. The relationship between variations in levels of serotonin acetyltransferase activity and cGMP content in cultured chick pineal glands. Can. J. Biochem. 59:1981;593-601.
317. Wainwright S. D., Wainwright L. K. Enzymes of guanine nucleotide metabolism and the diurnal cycle in cGMP content of the chick pineal gland. Can. J. Biochem. Cell Biol. 61:1983;137-143.
318. Wainwright S. D., Wainwright L. K. Phase-shifting of cycles in level of serotonin N-acetyltransferase activity and cyclic GMP content of cultured chick pineal glands by methotrexate. J. Neurochem. 43:1984;364-370.
319. Wang X. T., Pappas G. D., Sagen J., Unnerstall J. R. Cells expressing preproenkephalin mRNA in the rat pineal gland are not serotonin-producing pinealocytes: evidence using in situ hybridization combined with immunocytochemistry for serotonin. Cell Mol. Neurobiol. 16:1996;73-84.
320. Weaver D. R., Stehle J. H., Stopa E. G., Reppert S. M. Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. J. Clin. Endocrinol. Metab. 76:1993;295-301.
321. Wiechmann A. F., Craft C. M. Localization of mRNA encoding the indolamine synthesizing enzyme, hydroxyindole-O-methyltransferase, in chicken pineal gland and retina by in situ hybridization. Neurosci. Lett. 150:1993;207-211.
322. Yamazaki S., Maruyama M., Cagampang F. R., Inouye S. T. Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat. Brain Res. 651:1994;329-331.
323. Yañez J., Meissl H. Secretion of methoxyindoles from trout pineal organs in vitro: indication for a paracrine melatonin feedback. Neurochem. Int. 27:1995;195-200.
324. Yu H. S., Pang S. F., Tang P. L. Increase in the level of retinal melatonin and persistence of its diurnal rhythm in rats after pinealectomy. J. Endocrinol. 91:1981;477-481.
325. Zachmann, A., Ali, M. A. and Falcón, J. (1992a) Melatonin and its effects in fishes: an overview. In: Rhythms in Fishes, pp. 149-165. ED. M. A. Ali. Plenum Press, New York.
326. Zachmann A., Knijff S. C. M., Ali M. A., Anctil M. Effects of photoperiod and different intensities of light exposure on melatonin levels in the blood, pineal organ and retina of the brook trout (Salvelinus frontinalis Mitchill). Can. J. Zool. 70:1992;25-29.
327. Zachmann A., Falcón J., Knijff S. C., Bolliet V., Ali M. A. Effects of photoperiod and temperature on rhythmic melatonin secretion from the pineal organ of the white sucker (Catostomus commersoni) in vitro. Gen. Comp. Endocrinol. 86:1992;26-33.
328. Zatz M. Agents that affect calcium influx can change cyclic nucleotide levels in cultured chick pineal cells. Brain Res. 583:1992;304-307.
329. Zatz M. Does the circadian pacemaker act through cyclic AMP to drive the melatonin rhythm in chick pineal cells? J. Biol. Rhythms. 7:1992;301-311.
330. Zatz M. Melatonin rhythm: trekking toward the hart of darkness in the chick pineal. Cell Dev. Biol. 7:1996;811-820.
331. Zatz M., Mullen D. A. Does calcium influx regulate melatonin production through the circadian pacemaker in chick pineal cells? Effects of nitrendipine, Bay K 8644, Co2+, Mn2+, and low external Ca2+. Brain Res. 463:1988;305-316.
332. Zatz M., Kasper G., Marquez C. R. Vasoactive intestinal peptide stimulates chick pineal melatonin production and interacts with other stimulatory and inhibitory agents but does not show alpha 1-adrenergic potentiation. J. Neurochem. 55:1990;1149-1153.
333. Zatz M., Lange G. D., Rollag M. D. What does changing the temperature do to the melatonin rhythm in cultured chick pineal cells? Am. J. Physiol. 266:1994;R50-8.
334. Zhao X., Haeseleer F., Fariss R. N., Huang J., Baehr W., Milam A. H., Palczewski K. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Vis. Neurosci. 14:1997;225-232.
335. Zimmerman N. H., Menaker M. Neural connections of sparrow pineal: role in circadian control of activity. Science. 190:1975;477-479.
336. Zimmerman N. H., Menaker M. The pineal gland: a pacemaker within the circadian system of the house sparrow. Proc. natl Acad. Sci. USA. 76:1979;999-1003.
337. Zimmerman B. L., Tso M. O. Morphologic evidence of photoreceptor differentiation of pinealocytes in the neonatal rat. J. Cell Biol. 66:1975;60-75.
338. Zweig M., Snyder S. H., Axelrod J. Evidence for a non retinal pathway of light to pineal gland in newborn rats. Proc. natl Acad. Sci. USA. 56:1966;515-520.
339. Aschoff (1965): AUTHOR - PLEASE SUPPLY REFERENCE.
340. Gern and Karn (1983): AUTHOR - PLEASE SUPPLY REFERENCE.
341. Henderson and Dryer (1992): AUTHOR - PLEASE SUPPLY REFERENCE.
342. Kusmic et al. (1992): AUTHOR - PLEASE SUPPLY REFERENCE.
343. Pelham (1975): AUTHOR - PLEASE SUPPLY REFERENCE.
344. Ravault et al. (1997): AUTHOR - PLEASE SUPPLY REFERENCE.
345. Tilden and Hutchinson (1993): AUTHOR - PLEASE SUPPLY REFERENCE.