Effects of sustained cocaine exposure on sensorimotor gating of startle in rats

Psychopharmacology

Volumn 142, Issue 3, 1999, Pages 253-260

  Martinez, Zoe A ^a   Ellison, Gaylord D ^a   Geyer, Mark A ^b   Swerdlow, Neal R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cocaine; Neurotoxicity; Prepulse inhibition; Schizophrenia; Startle

Indexed keywords

COCAINE;

ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG DEPENDENCE; DRUG EFFECT; FEMALE; MOTOR ACTIVITY; NEUROCHEMISTRY; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE SPECIFICITY;

ACOUSTIC STIMULATION; ANIMALS; BRAIN; COCAINE; DOPAMINE UPTAKE INHIBITORS; FEMALE; HABITUATION, PSYCHOPHYSIOLOGIC; MOTOR ACTIVITY; OBSERVATION; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA; STARTLE REACTION;

EID: 0032955586     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050887     Document Type: Article

References (34)

1. 2 dopamine receptors in prepulse inhibition of the startle reflex in man. J Psychopharmacol 11 [Suppl 3]:A69
2. Bakshi VP, Swerdlow NR, Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271:787-794
3. Braff D, Stone C, Callaway E, Geyer MA, Glick ID, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343
4. Braff D, Grillon C, Geyer M (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215
5. Braff DL, Swerdlow NR, Geyer MA (1995) Prepulse intensity of the startle response in schizophrenia: the effects of varying prepulse intensity and gender. Proc Am Coll Neuropsychopharmacolp 107
6. Castellanos FX, Fine EJ, Kaysen DL, Kozuch PL, Hamburger SD, Rapoport JL, Hallet M (1996) Sensorimotor gating deficits in boys with Tourette's Syndrome and ADHD: preliminary results. Biol Psychiatr 39:33-41
7. Ellison G (1992) Continuous amphetamine and cocaine have similar neurotoxic effects in lateral habenular nucleus and fasciculus retroflexus. Brain Res 598:353-356
8. Ellison G (1994) Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula. Brain Res Rev 19:223-239
9. Ellison G, Switzer RC (1993) Dissimilar patterns of degeneration in brain following four different addictive stimulants. Neuro-Report 5:17-20
10. Geyer MA, Tapson GS (1988) Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors. Neuropsychopharmacology 1:135-147
11. Hoffman DC, Donovan H Cassella JV (1993) The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801. Psychopharmacology 111:339-344
12. Hutchinson KE, Swift R (1997) Effects of amphetamine on psychophysiological and subjective measures of stimulation in humans. Proc Soc Psychophysiol Res 545
13. Keith VA, Mansbach RS, Geyer MA (1991) Failure of haloperidol to block the effects of phencyclidine and dizolcipine on prepulse inhibition of startle. Biol Psychiatry 30:557-566
14. Lesko LM, Fischman M, Javaid J, Davis J (1982) latrogenous cocaine psychosis. N Engl J Med 307:1153-1156
15. Lipton JW, Ellison GD (1992) Continuous cocaine induces persisting changes in behavioral responsivity to both scopolamine and diazepam. Neuropsychopharmacology 7:143-148
16. Lipton J, Zeigler S, Wilkins J, Ellison G (1991) Silicone pellet for continuous cocaine administration: comparison with continuous amphetamine. Pharmacol Biochem Behav 38:927-930
17. Mansbach RS, Geyer MA (1989) Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2:299-308
18. Mansbach RS, Geyer MA (1991) Parametric determinants in prestimulus modification of acoustic startle: interaction with ketamine. Psychopharmacology 105:162-168
19. Mansbach RS, Geyer MA, Braff DL (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94:507-514
20. Manschreck TC, Laughery JA, Weisstein CC, Allen D, Humblestone B, Neville M, Podlewski H, Mitra N (1988) Characteristics of freebase cocaine psychosis. Yale J Biol Med 61:115-122
21. Morton N, Ellis C, Gray NS, Toone BK, Leigh PN, Chaudhuri KR (1995) The effects of apomorphine and L-dopa challenge on prepulse inhibition in patients with Parkinson's disease. Schizophr Res 15:181
22. Perry W, Braff D (1994) Information-processing deficits and thought disorder in schizophrenia. Am J Psychiatry 151:363-367
23. Sams-Dodd F (1998) A test of predictive validity of animal models of schizophrenia based on phencyclidine and D-amphetamine. Neuropsychopharmacology 18:293-304
24. Swerdlow NR, Geyer MA (1993) Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44:741-744
25. Swerdlow NR, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull (in press)
26. Swerdlow NR, Braff DL, Geyer MA, Koob GF (1986) Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biol Psychiatry 21:23-33
27. Swerdlow NR, Braff DL, Masten VL, Geyer MA (1990a) Schizophrenia-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology 101:414-420
28. Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL (1990b) Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology 100:413-416
29. Swerdlow NR, Keith VA, Braff DL, Geyer MA (1991) Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol Exp Ther 256:530-536
30. Swerdlow NR, Caine SB, Braff DL, Geyer MA (1992) The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications. J Psychopharmacol 6:176-190
31. Swerdlow NR, Braff DL, Taaid N, Geyer, MA (1994) Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51:139-154
32. Swerdlow NR, Paulsen J, Braff DL, Butters N, Geyer MA, Swenson MR (1995) Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's Disease. J Neurol Neurosurg Psychiat 58:192-200
33. 2 modulation of sensorimotor gating in rats: Assessing anatomical localization. Pharmacol Biochem Behav 49: 155-163
34. Zeigler S, Lipton J, Toga A, Ellison G (1991) Continuous cocaine administration produces persisting changes in brain neurochemistry and behavior. Brain Res 552:27-35