Large-scale HCV RNA screening in first-time blood donors: The first step towards genomic screening of blood donations

Vox Sanguinis

Volumn 76, Issue 3, 1999, Pages 159-162

  Petrik, Juraj ^a,b   Hewitt, Patricia ^b   Barbara, John ^b   Allain, Jean Pierre ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c East Anglia Blood Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ARTICLE; BLOOD BANK; BLOOD DONOR; DIAGNOSTIC ACCURACY; GENOME; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAFETY; SCREENING; UNITED KINGDOM;

AUTOANALYSIS; BLOOD DONORS; FEASIBILITY STUDIES; GENOME, VIRAL; GREAT BRITAIN; HEPACIVIRUS; HEPATITIS C; HUMANS; MASS SCREENING; PREVALENCE; RNA, VIRAL; TIME FACTORS;

EID: 0032954994     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1159/000031041     Document Type: Article

References (17)

1. Lee, H, Morse S, Olsvik O (eds): Nucleic Acid Amplification Technologies. Natik Eaton Publishing, 1997.
2. Rogers PM, Saldanha J, Allain JP: Report of EPFA/NIBSC Workshop 'Nucleic Acid Amplification Tests (NAT) for the Detection of Blood-Borne Viruses', Amsterdam, October 1996. Vox Sang 1997;72:199-206.
3. Saldanha J, Minor P: Incidence of hepatitis C virus RNA in anti-HCV-negative plasma pools and blood products. Vox Sang 1996;70:232-234.
4. Schottstedt V: Identification of a single virmic donation with PCR minipool testing in a large blood bank. Transfus Med 1997;7(suppl 1):14.
5. Petrik J, Pearson GJM, Allain JP: High throughput PCR detection of HCV based on semiautomated multisample RNA capture. J Virol Methods 1997;64:147-159.
6. Giachetti C, Kolk D, Yang Y, Dockter J, Wang R, Hotaling S, Sitay A, McDonough S, Mimms L: A high throughout assay for sensitive detection of HCV RNA (abstract S444). Transfusion 1997(suppl 11S).
7. Kwok S, Higuchi R: Avoiding false positives with PCR. Nature 1989;339:237.
8. Soldan K, Barbara JAJ, Heptonstall J: Incidence of seroconversion to positivity for hepatitis C antibody in repeat blood donors in England 1993-5. Br Med J 1998;316:1413-1417.
9. Surveillance of viral infections in donated blood: England and Wales, 1996. Commun Dis Rep 1997;7:258.
10. Sugitani M, Inchauspe G, Shindo M, Prince AM: Sensitivity of serological assays to identify blood donors with hepatitis C viraemia. Lancet 1992;339:1018-1019.
11. Vrielink H, van der Poel CL, Reesink HW, Lelie PN: Transmission of hepatitis C virus by anti-HCV negative blood transfusion. Vox Sang 1995;68:55-56.
12. Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ: The risk of transfusion-transmitted viral infections. N Engl J Med 1996;334:1685-1690.
13. Williamson LM, Heptonstall J, Soldan K: A SHOT in the arm for safer blood transfusion. Br Med J 1996;313:1221-1222.
14. Busch MP, Taylor PE, Lenes BA, et al: Screening of selected male blood donors for p24 antigen of human immunodeficiency virus type 1. N Engl J Med 1990;323:1308-1312.
15. Blajchman MA, Bull SB, Feinman SV: Posttransfusion hepatitis: impact of non-A, non-B hepatitis surrogate tests. Lancet 1995;345:21-25.
16. Vrielink H, Zaaijer HL, Reesink HW, et al: Sensitivity and specificity of three third-generation anti-hepatitis C virus ELISAs. Vox Sang 1995;69:14-17.
17. Allain JP: Genomic screening of blood donations: which way to go. Transfus Med 1998;8: 6-8.