Aldosterone metabolism in cultures of rat renal cortical and medullary cells

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 59, Issue 2, 1999, Pages 107-113

  Egfjord, M ^a   Dahl, H B ^b   Kayser, C ^b   Blaehr H ^b  

^a University of Copenhagen   (Denmark)

^b NONE

Author keywords

Aldosterone metabolism; Rat renal cortical and medullary cell cultures; Steroid

Indexed keywords

CANRENOATE POTASSIUM; CANRENOIC ACID; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR;

ALDOSTERONE BLOOD LEVEL; ALDOSTERONE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CHROMATOGRAPHY; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; STEROID BLOOD LEVEL; STEROID METABOLISM;

EID: 0032954965     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365519950185832     Document Type: Article

References (25)

1. 3H- aldosterone in human liver and kidneys and renal extraction of aldosterone and labeled conjugates from blood plasma. J Clin Endocrinol 1965; 25: 628-38.
2. Siegenthaler WE, Peterson RE, Frimpter GW. The renal clearance of aldosterone and its major metabolites. In: Baulieu EE, Robel P, editors. Aldosterone. Oxford, Blackwell, 1964: 51-72.
3. Scurry MT, Shear L, Barry KG. The renal tubular handling of aldosterone and its acid-labile conjugate. J Clin Invest 1968; 47: 242-8.
4. Deck KA, Siegenthaler WE. Further experimental evidence for the formation of the acid hydrolyzable conjugate of aldosterone by the kidney. Acta Endocrinol 1967; 55: 637-47.
5. Deck KA, Siegenthaler WE. Transport of aldosterone and of the acid labile conjugate of aldosterone by tubular cells of the kidney. Acta Endocrinol 1967; 55: 648-55.
6. Carpenter PC, Mattox VR. Isolation, determination of structure and synthesis of the acid labile conjugate of aldosterone. Biochem J 1976; 157: 1-14.
7. Morris DJ, McDermott MJ, Latif SA, Keating A, Kenyon CJ. The metabolism of aldosterone in target tissues. J Steroid Biochem 1981; 15: 473-7.
8. McDermott MJ, Latif SA, Morris DJ. The metabolism of aldosterone in the kidney. J Steroid Biochem 1983; 19: 1205-11.
9. McDermott MJ, Freiberger M, Latif SA, Morris DJ. The synthesis of reduced metabolites of aldosterone by subcellular fractions of rat kidney: effects of antimineralocorticoids. J Steroid Biochem 1985; 23: 503-9.
10. Allemand F D, Siebe H, Tsiakiras D, Hoyer GA, Vecseí P, Hierholzer K. Aldosterone metabolism in rat renal tissue in vitro. Formation of lipid soluble metabolites. Pflugers Arch 1988; 411: 529-39.
11. Farman N, Pradelles P, Bonvalet JP. Binding of aldosterone metabolites in isolated tubular segments. Am J Physiol 1985; 249: E923-32.
12. Charest-Boule L, Mehdi AZ, Sandor T. Cortico-steroid receptors in the avian kidney. Steroids 1978; 32: 109-26.
13. Morris DJ, Latif SA, Conca TJ, Wei L, Watlington CO, Kirk DN, Toms HC, Shackleton CHL. Synthesis of 6β-hydroxyaldosterone by A6 (toad kidney) cells in culture. Steroids 1990; 55: 482-7.
14. Matsuzaki K, Kimura K, Kurokawa K, Miyazaki T. Identification of aldosterone metabolites formed by A6 cells. J Steroid Biochem Molec Biol 1991; 38: 657-62.
15. Morris DJ, McDermott MJ, Freiberger M, Latif SA, Pacholski M, Brem AS. The effects of antimineralocorticoids on synthesis of aldosterone metabolites in target tissues. J Steroid Biochem 1986; 24: 341-4.
16. Brem AS, Pacholski M, Morris DJ. Time-dependent aldosterone metabolism in toad urinary bladder. Am J Physiol 1988; 254: F547-53.
17. Egfjord M, Daugaard H, Olgaard K. Aldosterone metabolism in combined isolated perfused liver and kidney. Am J Physiol 1991; 260: F536-48.
18. Nakane H, Nakane Y, Reach G, Corvol P, Menard J. Aldosterone metabolism in isolated perfused rat kidney. Am J Physiol 1978; 234: E472-9.
19. Hatano T, Ogawa K, Yamamoto M, Kanda K, Matsui N. Rat renal cell monolayer culture: a sensitive method for investigating ADH and PTH actions on the kidney by determining adenosine 3′:5′-cyclic monophosphate. Endocrinol Japon 1985; 32: 215-23.
20. Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976; 72: 248-54.
21. Egfjord M, Olgaard K. Aldosterone metabolism in the isolated perfused liver of female and male rats. Endocrinology 1989; 125: 3011-21.
22. Blæhr H, Friis S. Acute inhibition of human tubular cell growth by cyclosporin A. Pharmacol Toxicol 1990; 66: 115-20.
23. Egfjord M. Corticosteroid metabolism in isolated perfused rat liver and kidney. Acta Physiol Scand 1995; 155: Suppl 627: 1-42.
24. Morris DJ, Brem AS. Metabolic derivatives of aldosterone. Am J Physiol 1987; 252: F365-73.
25. Rafestin-Oblin ME, Couette B, Radanyi C, Lombès M, Baulieu EE. Mineralocorticosteroid receptor of the chick intestine. Oligomeric structure and transformation. J Biol Chem 1989; 264: 9304-9.