Complement activation and increased systemic and pulmonary vascular resistance indices during infusion of postoperatively drained untreated blood

British Journal of Anaesthesia

Volumn 82, Issue 1, 1999, Pages 47-51

  Krohn, C D ^a   Reikeras O ^a   Mollnes, T E ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Blood, coagulation; Blood, transfusion; Cardiovascular system, effects; Surgery, orthopaedic

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3BC; TERMINAL COMPLEMENT COMPLEX; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTERY CATHETERIZATION; ARTICLE; BLOOD AUTOTRANSFUSION; BLOOD SAMPLING; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HEMODYNAMIC PARAMETERS; HUMAN; LEUKOCYTE COUNT; LUNG VASCULAR RESISTANCE; MALE; PRIORITY JOURNAL; SCOLIOSIS; STATISTICAL ANALYSIS; SYSTEMIC VASCULAR RESISTANCE; WOUND CLOSURE;

EID: 0032954776     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/82.1.47     Document Type: Article

References (27)

1. Fosse E, Mollnes TE, Ingvaldsen B. Complement activation during major surgery with or without cardiopulmonary bypass. J Thorac Cardiovasc Surg 1987; 93: 860-6
2. Gardinali M, Calcagno A, Conciato L, et al. Complement activation in dialysis: effects on cytokines, lymphocyte activation and β2-microglobulin. Int J Artif Organs 1994; 17: 337-44
3. Lundberg L, Johansen G, Karlsson L, Stegmayr BG. Complement activation is influenced by the membrane material, design of the dialyzer, sterilising method and type of dialysate. Nephrol Dial Transplant 1994; 9: 1310-14
4. Moat NE, Shore DF, Evans TW. Organ dysfunction and cardiopulmonary bypass: the role of complement and complement regulatory proteins. Eur J Cardiothorac Surg 1993; 7: 563-73
5. Saatvedt K, Lindberg H, Geiran OR, et al. Complement activation and release of tumour necrosis factor and interleukin-2 receptors, during and after cardiopulmonary bypass in children. Scand J Clin Lab Invest 1995; 55: 79-86
6. Steinberg JB, Kapelanski DP, Olson JD, Weiler JM. Cytokine and complement levels in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 1993; 106: 1008-16
7. Videm V, Fosse E, Mollnes TE, Garred P, Svennevig JL. Time for new concepts about measurement of complement activation by cardiopulmonary bypass. Ann Thorac Surg 1992; 54: 725-31
8. DeBoer JP, Wolbink GJ, Thijs LG, et al. Interplay of complement and cytokines in the pathogenesis of septic shock. Immunopharmacology 1992; 24: 135-48
9. Sprung, CL, Schultz DR, Marcial E, et al. Complement activation in septic shock patients. Crit Care Med 1986; 14: 525-8
10. Langlois PF, Gawryl M. Accentuated formation of the terminal C5b-9 complement complex in patients plasma precedes development of the adult respiratory distress syndrome. Am Rev Respir Dis 1988; 138: 368-75
11. Hohn DC, Meyers AJ, Gherini ST, et al. Production of acute pulmonary injury by leukocytes and activated complement. Surgery 1980; 88: 48-58
12. Mollnes TE, Fosse E. The complement system in trauma-related and ischemic tissue damage: a brief review. Shock 1994; 2: 301-10
13. Faris PM, Ritter MA, Keating EM, Valeri R. Unwashed filtered shed blood collected after knee and hip arthroplasties. J Bone Joint Surg 1991; 73: 1169-78
14. Russel W, Tetzlaff JE. Upper airway oedema following autologous blood transfusion from a wound drainage system. Can J Anaesth 1992; 39: 290-2
15. Hugli TE, Marceau F, Lundberg C. Effects of complement fragments on pulmonary and vascular smooth muscle. Am Rev Respir Dis 1987; 135: 9-13
16. Ishikawa S, Tsukada H, Battacharya J. Soluble complex of complement increases hydraulic conductivity in single vessels of rat lung. J Clin Invest 1993; 91: 103-9
17. Arnestad JP, Bengtsson A, Bengtson JP, et al. Release of cytokines, polymorphonuclear elastase and terminal C5b-9 complement complex by infusion of wound drainage blood. Acta Orthop Scand 1995; 66: 334-8
18. Bengtson JP, Backman L, Stenquist O, Heideman M, Bengtsson A. Complement activation and reinfusion of wound drainage blood. Anesthesiology 1990; 73: 376-80
19. Krohn CD, Reikerås O, Mollnes TE, Aasen AO. Complement activation and release of interleukin-6 and tumour necrosis factor-α in drained and systemic blood after major orthopaedic surgery. Eur J Surg 1998; 164: 103-8
20. Mollnes, TE. Analysis of in vivo complement activation. In: Herzenberg LA, Weir DM, Herzenberg LA, Blackwell C, eds. Weirs Handbook of Experimental Immunology, No. 25. Boston: Blackwell Science, 1997; 78.1-78.8
21. Garred P, Mollnes TE, Lea T, Fischer E. Characterisation of monoclonal antibody MoAb bH6 reacting with neoepitope of human C3 expressed on C3b, iC3b and C3c. Scand J Immunol 1988; 27: 319-27
22. Mollnes TE, Lea T, Harboe M, Tschopp J. Monoclonal antibodies recognising a neoantigen of poly(C9) detected the human terminal complement complex in tissue and plasma. Scand J Immunol 1985; 22: 183-95
23. Wagner JL, Hugli TE. Radioimmunoassay for anaphylatoxins: a sensitive method for determining complement activation products in biological fluids. Ann Biochem 1984; 136: 75-88
24. Mollnes TE. Early-and late-phase activation of complement evaluated by plasma levels of C3d,g and the terminal complement complex. Complement 1985; 2: 156-64
25. Mollnes TE, Videm V, Gotze O, Harboe M, Oppermann M. Formation of C5a during cardiopulmonary bypass - inhibition by precoating with heparin. Ann Thorac Surg 1991; 52: 92-7
26. Haviland DL, Mccoy RL, Whitehead WT, et al. Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of CSaR on nonmyeloid cells of the liver and lung. J Immunol 1995; 154: 1861-9
27. Varsano S, Frolkis I, Ophir D. Expression and distribution of cell-membrane complement regulatory glycoproteins along the human respiratory tract. Am J Respir Crit Care Med 1995; 152: 1087-93