Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 21, Issue 2, 1999, Pages 105-113

  Barber, Andrew ^a   Bender, H M ^a   Gottschlich, R ^a   Greiner, H E ^a   Harting, J ^a   Mauler, F ^b   Seyfried, C A ^a  

^a MERCK KGAA   (Germany)

^b BAYER AG   (Germany)

Author keywords

EMD 61569; EMD 61747; GR 89696; MCAO; Neuroprotection; OP2 agonist; Peripherally selective; Permanent focal ischemia

Indexed keywords

4 [(3,4 DICHLOROPHENYL)ACETYL] 3 (1 PYRROLIDINYLMETHYL) 1 PIPERAZINECARBOXYLIC ACID METHYL ESTER; EMD 61569; EMD 61747; N METHYL N [1 PHENYL 2 (3 HYDROXYPYRROLIDINE 1 YL) ETHYL] 2 (2,3 DIHYDRO 2 OXO BENZOXAZOL 5 YL)ACETAMIDE HYDROCHLORIDE; N METHYL N [1 PHENYL 2 (3 HYDROXYPYRROLIDINE 1 YL) ETHYL] 2 (4 METHANESULFONYLAMINOPHENYL)ACETAMIDE HYDROCHLORIDE; NARCOTIC AGENT; OPIATE AGONIST; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTERY OCCLUSION; ARTICLE; BLOOD BRAIN BARRIER; BODY TEMPERATURE; BRAIN ISCHEMIA; DOPAMINE RELEASE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; MIDDLE CEREBRAL ARTERY; NEUROPROTECTION; NONHUMAN; NUCLEUS ACCUMBENS; RAT; VAS DEFERENS;

EID: 0032954355     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1999.21.2.529237     Document Type: Article

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