Adjustment of carbamazepine dose to offset the effects of the interaction with remacemide hydrochloride in a double-blind, multicentre, add-on drug trial (CR2237) in refractory epilepsy

Epilepsia

Volumn 40, Issue 2, 1999, Pages 190-196

  Mawer, George E ^a   Jamieson, Virginia ^b   Lucas, Samuel B ^a   Wild, Janet M ^a  

^a David Lewis Centre   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Carbamazepine; Interaction; Remacemide; Shewart control chart

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; REMACEMIDE;

ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENMARK; DOSE CALCULATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENTIATION; EPILEPSY; HUMAN; HUMAN CELL; HUMAN TISSUE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEIZURE;

ACETAMIDES; ANTICONVULSANTS; CARBAMAZEPINE; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; EPILEPSY; HUMANS; PLACEBOS; RESEARCH DESIGN; TREATMENT OUTCOME;

EID: 0032953593     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1999.tb02074.x     Document Type: Article

References (8)

1. Leach JP, Blacklaw J, Stewart M, et al. Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites. Epilepsia 1996;37:1100-6.
2. Marks, V. Immunoassays for drugs. In: Richens A, Marks V, eds. Therapeutic drug monitoring. Edinburgh: Churchill Livingstone, 1981:155-82.
3. Shewart WA. Economic control of quality of manufactured product. Princeton: Reinhold, 1931.
4. Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E. Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference. Epilepsy Res 1996;25:299-319.
5. Leppik IE, Dreifuss FE, Porter R, et al. A controlled study of progabide in partial seizures. Neurology 1987;37:963-8.
6. Leppik IE. Interactions between novel and standard antiepileptic drugs in clinical trials: progabide, felbamate and MK 801. In: Pitlick WH, ed. Antiepileptic drug interactions. New York: Demos, 1989:115-28.
7. Leppik IE. Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population. In: Schmidt D, Leppik IE, eds. Compliance in epilepsy (Epilepsy Res Suppl 1) Elsevier Science Publishers, 1988:85-90.
8. Tucker GT. Principles of pharmacokinetics. In: Richens A, Marks V, eds. Therapeutic drug monitoring. Edinburgh: Churchill Livingstone, 1981:31-53.