Neighboring glycine residues are essential for P2X2 receptor/channel function

European Journal of Pharmacology

Volumn 370, Issue 3, 1999, Pages R5-

  Nakazawa, Ken ^a   Ohno, Yasuo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

P2X receptor channel; Site directed mutagenesis; Xenopus oocyte

Indexed keywords

AMINO ACID; GLYCINE; PURINE P2X RECEPTOR;

ANIMAL CELL; CONTROLLED STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SHORT SURVEY; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

EID: 0032953496     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00159-4     Document Type: Article

References (7)

1. Brake A., Wagenbach M.J., Julius D. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature. 371:1994;519-523.
2. Buell G., Lewis C., Collo G., North R.A., Surprenant A. An antagonist insensitive P2X receptor expressed in epithelia and brain. EMBO J. 15:1996;55-62.
3. 6 receptors and the distribution of an extended family of ATP-gated ion channels. J. Neurosci. 16:1996;2495-2507.
4. Freist W., Verhey J.F., Stühmer W., Gauss D.H. ATP binding site of P2X channel proteins: structural similarities with class II aminoacyl-tRNA synthetases. FEBS Lett. 434:1998;61-65.
5. Nakazawa K., Ohno Y., Inoue K. An aspartic acid residue near the second transmembrane segment of ATP receptor/channel regulates agonist sensitivity. Biochem. Biophys. Res. Commun. 244:1998;599-603.
6. Walker J.E., Saraste M., Runswick M.J., Gay N.J. Distantly related sequences in the α- and β-subunits of ATP synthase, myosin kinase and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1:1982;945-951.
7. II-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition. J. Mol. Biol. 282:1998;149-165.