Esculetin suppresses proteoglycan metabolism by inhibiting the production of matrix metalloproteinases in rabbit chondrocytes

European Journal of Pharmacology

Volumn 370, Issue 3, 1999, Pages 297-305

  Watanabe, Koju ^a   Ito, Akira ^b   Sato, Takashi ^b   Saito, Tsuyoshi ^a   Hayashi, Haruhisa ^a   Niitani, Yoshiaki ^a  

^a KUREHA CORPORATION   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

6,7 Dihydroxycoumarin; Chondrocyte; Esculetin; Matrix metalloproteinase; Osteoarthritis; Proteoglycan

Indexed keywords

CHONDROPROTECTIVE AGENT; ESCULETIN; INTERLEUKIN 1; MATRIX METALLOPROTEINASE; PROCOLLAGEN; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; DENSITOMETRY; IMMUNOBLOTTING; MALE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; RABBIT;

ANIMALS; ANTIOXIDANTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CHONDROCYTES; COLLAGENASES; DRUG INTERACTIONS; ENZYME PRECURSORS; HUMANS; INTERLEUKIN-1; JOINTS; KNEE; MALE; METALLOENDOPEPTIDASES; PHENANTHROLINES; PROTEASE INHIBITORS; PROTEOGLYCANS; RABBITS; RNA; SHOULDER; UMBELLIFERONES;

EID: 0032952422     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00143-0     Document Type: Article

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