A new methodology for controlled particle inhalation by small rodents

Experimental Lung Research

Volumn 25, Issue 2, 1999, Pages 113-125

  Waber, U ^a   Im Hof, V ^b   Geiser, M ^a   Baumann, M ^a   Scheuch, G ^c   Gebhardt, J ^c   Stahlhofen, W ^c   Gehr, P ^a,d  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Breathing pattern; Continuous negative pressure ventilation; On line open flow set up; Particle deposition ratio; Syrian golden hamster

Indexed keywords

MICROSPHERE; POLYBEAD 7312; POLYSTYRENE; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; BREATHING PATTERN; BREATHING RATE; CONTROLLED STUDY; INHALATION; INHALATIONAL DRUG ADMINISTRATION; LUNG INFLATION; MALE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; SYRIAN HAMSTER; TIDAL VOLUME;

EID: 0032952373     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.1080/019021499270330     Document Type: Article

References (13)

1. Sweeney TD: Exposing animals to aerosols: considerations that influence regional lung deposition. J Aerosol Med. 1990;3:169-186.
2. Harbison ML, Brain JD: Effect of exercise on particle deposition in Syrian golden hamster. Am Rev Respir Dis. 1983;128:904-908.
3. Sweeney TD, Tryka AF, Brain JD: Effects of exercise on redistribution and clearance of inhaled particles from hamster lungs. J Appl Physiol. 1990;68:967-972.
4. Zeltner TB, Sweeney TD, Skornik WA, Feldman HA, Brain JD: Retention and clearance of 0.9 μm particles inhaled by hamsters during rest or exercise. J Appl Physiol. 1991;70:1137-1145.
5. Sweeney TD, Leith DE, Brain JD: Restraining hamsters alters their breathing pattern. J Appl Physiol. 1991;70:1271-1276.
6. Vinegar A, Sinnett EE, Leith DE: Dynamic mechanisms determine functional residual capacity in mice, Mus musculus. J Appl Physiol: Respir Environ Exercise Physiol. 1979;46:867-871.
7. Sweeney TD, Brain JD, LeMott S: Anesthesia alters the pattern of aerosol retention in hamsters. J Appl Physiol. 1983;54:37-44.
8. Skornik, WA, Brain JD: Breathing and lung mechanics in hamsters: effect of pentobarbital anesthesia. J Appl Physiol. 1990;68:2536-2541.
9. Im Hof V, Scheuch G, Geiser M, Gebhardt J, Gehr P, Heyder J: Techniques for the determination of particle deposition in lungs of hamsters. J Aerosol Med. 1989;3:247-259.
10. Lorino, MA, Bénichou M, Macquin-Mavier I, Lorino H, Harf A: Respiratory mechanics for assessment of histamine bronchopulmonary reactivity in guinea pigs. Respir Physiol. 1988;73:155-162.
11. Koo KW, Leith DE, Sherter CB, Snider GL: Respiratory mechanics in normal hamster. J Appl Physiol. 1976;40:936-942.
12. Lai YL: Lung volume and pleural pressure in the anesthetized hamster. J Appl Physiol: Respir Environ Exercise Physiol. 1979;46:927-931.
13. Geiser M, Cruz-Orive LM, Waber U, Im Hof V, Gehr P: Particle retention in airways estimated by unbiased stereology and photometry. J Aerosol Med. 1995;8:149-169.