Does sulphasalazine cause drug induced systemic lupus erythematosus? No effect evident in a prospective randomised trial of 200 rheumatoid patients treated with sulphasalazine or auranofin over five years

Annals of the Rheumatic Diseases

Volumn 58, Issue 5, 1999, Pages 288-290

  Gordon, Margaret Mary ^a   Porter, Duncan R ^b   Capell, Hilary A ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AURANOFIN; RHEUMATOID FACTOR; SALAZOSULFAPYRIDINE;

ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG INDUCED DISEASE; EVIDENCE BASED MEDICINE; FOLLOW UP; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MOUTH ULCER; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0032952111     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.58.5.288     Document Type: Article

References (20)

1. 1 Hess E. Drug-related lupus. N Engl J Med 1988;318:1460-3.
2. 2 Clementz GL, Dolin BJ. Sulfasalazine-induced lupus erythematosus. Am J Med 1988;84:535-8.
3. 3 Laversuch CJ, Collins DA, Charles PJ, Bourke BE. Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease. Br J Rheumatol 1995;34: 435-9.
4. 4 Caulier M, Dromer C, Andrieu V, Le Guennec P, Fournie B. Sulphasalazine-induced lupus in rheumatoid arthritis. J Rheumatol 1994;21:750-1.
5. 5 Carr-Locke DL. Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease. Am J Gastroenterol 1983;77: 614-16.
6. 6 Griffiths ID, Kane SP. Sulphasalazine-induced lupus syndrome in ulcerative colitis. BMJ 1997;2:188-9.
7. 7 Deboever G, Devogelaere R, Holvoet G. Sulphasalazine-induced lupus like syndrome with cardiac tamponade in a patient with ulcerative colitis. Am J Gastroenterol 1988;84: 85-6.
8. 8 Veale DJ, Ho M, Morley KD. Sulphasalazine-induced lupus in a patient with psoriatic arthritis. Br J Rheumatol 1995;34:383-4.
9. 9 Hobbs RN, Clayton AL, Bernstein RM. Antibodies to the five histones and poly (adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis. Ann Rheum Dis 1987;46:408-16.
10. 10 Skaer TL. Medication-induced systemic lupus erythematosus. Clin Ther 1992;14:496-506.
11. 11 Stratton MA. Drug induced systemic lupus erythematosus. Clinical Pharmacy 1985;4:657-63.
12. 12 Mc Entegert A, Porter D, Capell HA, Thomson EA. Sulfasalazine has a better efficacy/ toxicity profile than auranofin: evidence from a 5 year prospective, randomized trial. J Rheumatol 1996;23:1887-90.
13. 13 Porter DR, McInnes I, Hunter J, Capell HA. Outcome of second line therapy in rheumatoid arthritis. Ann Rheum Dis 1994;53:812-15.
14. 14 Barnett EV, North AE, Condemi JJ. Anti nuclear factors in systemic lupus erythematosus and rheumatoid arthritis. Ann Intern Med 1965;63:100-8.
15. 15 Linn JE, Hardin JG, Halla JT. A controlled study of ANA+ and RF-arthritis. Arthritis Rheum 1978;21:645-51.
16. 16 Caulier M, Dromer C, Andrieu V, Le Guennec P, Fournie B. Sulfasalazine induced lupus in rheumatoid arthritis. J Rheumatol 1994;21:750-1.
17. 17 Alarcon-Segovia D, Kraus A. Drug related lupus syndromes and their relationship to spontaneously occurring systemic lupus erythematosus. Ballieres Clin Rheumatol 1991;5:1-12.
18. 18 Mongey AB, Hess EV. Sulphasalazine-induced systemic lupus erythematosus. Br J Rheumatol 1994;33:789-90.
19. 19 Mielke H, Wildhangen K, Mau W, Ziedler H. Follow up of patients with double stranded DNA antibodies induced by sulfasalazine during the treatment of inflammatory rheumatic diseases. Scand J Rheumatol 1993;22:299-301.
20. 20 Drayer DE, Reidenberg MM. Clinical consequences of polymorphic acetylation of basic drugs. Clin Pharmacol Ther 1977;22:251-8.