Substituted xanthones as antimycobacterial agents. Part 3: QSAR investigations

Archiv der Pharmazie

Volumn 332, Issue 3, 1999, Pages 91-102

  Schaper, Klaus Jürgen ^a   Pickert, Martina ^b   Frahm, August Wilhelm ^b  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Adaptive least squares; Antituberculous activity; Artificial neural networks; QSAR; Xanthones

Indexed keywords

ISONIAZID; RIFAMPICIN; XANTHONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL NEURAL NETWORK; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; INTERMETHOD COMPARISON; LIPID SOLUBILITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0032951602     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(19993)332:3<91::AID-ARDP91>3.0.CO;2-D     Document Type: Article

References (35)

1. M. Pickert, A.W. Frahm, Arch.Pharm. Pharm.Med.Chem. 1998, 331, 177-192.
2. M. Pickert, K.-J. Schaper, A. W. Frahm, Arch.Pharm. Pharm.Med.Chem. 1998, 331, 193-197.
3. L. W. Riley, Clin.Infect.Dis. 1993, 17 (Suppl.2) S442-S444
4. J. K. Seydel, K.-J. Schaper, Pharm. in uns. Zeit 1995, 24, 313-323.
5. M. Goble, M. D. Iseman, L. A. Madsen, D. Waite, L. Ackerson, R. Horshurgh Jr., New Engl.J.Med. 1993, 328, 527-532.
6. H. Hambloch, A. W. Frahm, B. Wiedemann, Eur.J.Med.Chem. 1985, 20, 71-77.
7. W. Ibrom, PhD Thesis, University of Freiburg, Germany, 1995.
8. W.G. Ibrom, K.-J. Schaper, A. W. Frahm, Arzneim.-Forsch./Drug Res. 1997, 47, 767-773.
9. J. Ungwitayatorn, M. Pickert, A. W. Frahm, Pharm. Acta Helv. 1997, 72, 23-29.
10. C. Hansch, A. Leo, D. Hoekman, Exploring QSAR: Hydrophobic, Electronic and Steric Constants, American Chemical Society, Washington DC 1995.
11. J. K. Seydel, K.-J. Schaper, Chemische Struktur und biologische Aktivität von Wirkstoffen; Methoden der Quantitativen Struktur-Wirkung-Analyse, Verlag Chemie, Weinheim 1979.
12. H. Nikaido, V. Jarlier, Forum Microbiol. 1991, 7, 437-443.
13. P.J. Brennan, H. Nikaido, Annu.Rev.Biochem. 1995, 64, 29-63.
14. N. Rastogi, C. Frehel, A. Ryter, H. Ohayon, M. Lesourd, H.L. David, Antimicrob.Agents Chemother. 1981, 20, 666-677.
15. N. Rastogi, W.W. Barrow, Res.Microbiol. 1994, 145, 243-252.
16. S. H. Unger, T. F. Feuerman, J. Chromatogr. 1979, 176, 426-429.
17. H. Kubinyi, QSAR: Hansch Analysis and Related Approaches, Vol.1 in R. Mannhold, P. Krogsgaard-Larsen, H. Timmerman (Eds.), Methods and Principles in Medicinal Chemistry, VCH, Weinheim 1993.
18. H. Kubinyi, QSAR: Hansch Analysis and Related Approaches, Vol.1 in R. Mannhold, P. Krogsgaard-Larsen, H. Timmerman (Eds.), Methods and Principles in Medicinal Chemistry, VCH, Weinheim 1993.
19. K.-J. Schaper, in D. Hadzy, B. Jerman-Blazic (Eds.), QSAR in Drug Design and Toxicology, Elsevier, Amsterdam 1987, 58-60.
20. K.-J. Schaper, A. K. Saxena, in C. Silipo, A. Vittoria (Eds.), QSAR: Rational Approaches to the Design of Bioactive Compounds, Elsevier, Amsterdam 1991, 45-48.
21. M. Wiese, K.-J. Schaper, SAR and QSAR in Environm.Res., 1993, 1, 137-152.
22. K.-J. Schaper, in H. van de Waterbeemd (Ed.), Advanced Computer Assisted Techniques in Drug Discovers, Vol.3 in R. Mannhold, P. Krogsgaard-Larsen, H. Timmerman (Eds.), Methods and Principles in Medicinal Chemistry, VCH, Weinheim 1995, 244-280.
23. K.-J. Schaper, in H. van de Waterbeemd (Ed.), Advanced Computer Assisted Techniques in Drug Discovers, Vol.3 in R. Mannhold, P. Krogsgaard-Larsen, H. Timmerman (Eds.), Methods and Principles in Medicinal Chemistry, VCH, Weinheim 1995, 244-280.
24. I. Moriguchi, K. Komatsu, Y. Matsushita, J. Med. Chem. 1980, 23, 20-26.
25. Y. Kawashima, F. Amanuma, M. Sato, S. Okuyama, Y. Nakashima, K. Sota, I. Moriguchi, J. Med. Chem. 1986, 29, 2284-2290.
26. T. Aoyama, H. Ichikawa, Chem.Pharm.Bull. 1991, 39, 358-366.
27. J. Zupan, J. Gasteiger, Neural Networks for Chemists - An Introduction, VCH, Weinheim 1993.
28. T. Aoyama, H. Ichikawa, Chem.Pharm.Bull 1991, 39, 1222-1228.
29. D. T. Manallack, D. J. Livingstone, in H. van de Waterbeemd (Ed.), Advanced Computer Assisted Techniques in Drug Discovery, Vol.3 in R. Mannhold, P. Krogsgaard-Larsen, H. Timmerman (Eds.), Methods and Principles in Medicinal Chemistry, VCH, Weinheim 1995, 293-318.
30. D. T. Manallack, D. J. Livingstone, in H. van de Waterbeemd (Ed.), Advanced Computer Assisted Techniques in Drug Discovery, Vol.3 in R. Mannhold, P. Krogsgaard-Larsen, H. Timmerman (Eds.), Methods and Principles in Medicinal Chemistry, VCH, Weinheim 1995, 293-318.
31. T. A. Andrea, H. Kalayeh, J.Med.Chem. 1991, 34, 2824-2836.
32. G. Hripcsak, M.D.Computing 1988, 5, 25-37.
33. T. Tollenaere, Neural Networks, 1990, 3, 561-573.
34. J. Moody, in V. Cherkassky, J.H. Friedman, H. Wechsler (Eds.), From Statistics to Neural Networks: Theory and Pattern Recognition Application: NATO ASI Series F: Computer and Systems Science, Vol. 136, Springer, Berlin 1994, 147-165.
35. M. Hesse, H. Maier, B. Zeeh, Spektroskopische Methoden in der organischen Chemie, Thieme Verlag, Stuttgart 1991.