Dipyridamole modulated Tc-99m sestamibi lung SPECT in small cell lung cancer

Clinical Nuclear Medicine

Volumn 24, Issue 2, 1999, Pages 97-101

  Bom, Hee Seung ^a   Lim, Sung Chul ^a   Kim, Young Chul ^a   Song, Ho Cheon ^a   Min, Jung Jun ^a   Jeong, Hwan Jeong ^a   Kim, Ji Yeul ^a   Lee, Jaetae ^b   Park, Kyung Ok ^a  

^a Chonnam National University Medical School   (South Korea)

^b Kyungpook National University Hospital   (South Korea)

Author keywords

Dipyridamole; P glycoprotein; Small Cell Lung Cancer; Tc 99m Sestamibi

Indexed keywords

CISPLATIN; DIPYRIDAMOLE; ETOPOSIDE; GLYCOPROTEIN P; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; VERAPAMIL;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG SMALL CELL CANCER; MALE; PREDICTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SMALL CELL; CISPLATIN; DIPYRIDAMOLE; DRUG RESISTANCE, MULTIPLE; ETOPOSIDE; FEMALE; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; P-GLYCOPROTEIN; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M SESTAMIBI; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0032950475     PISSN: 03639762     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003072-199902000-00004     Document Type: Article

References (20)

1. Deuchars KL, Lung V: P-glycoprotein and multidrug resistance in cancer chemotherapy. Semin Oncol 1989; 16:156.
2. Piwnica-Worms D, Chiu ML, Budding M, et al: Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res 53:977, 1993.
3. Bom HS, Kim YC, Song HC, et al: Tc-99m sestamibi uptake in small cell lung cancer. J Nucl Med 39:91, 1998.
4. Howell SB, Hom DK, Sanga R, Vick JS, Chan TC: Dipyridamole enhancement of etoposide sensitivity. Cancer Res 49:4147, 1989.
5. Shalinsky DR, Howell SB: Synergistic enhancement of the cytotoxicity of vinblastine and colchicine by dipyridamole in drug resistant KB carcinoma cells. Proc Am Assoc Cancer Res 30: 527, 1989.
6. Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 47:207, 1981.
7. Benson AB, Trump DL, Koehler JM, et al: Phase I study of vinblastine and verapamil given by concurrent iv infusion. Cancer Treat Rep 69:795, 1985.
8. Ozols RF, Cunnion RE, Klecker RW Jr, et al: Verapamil and Adriamycin in the treatment of drug-resistant ovarian cancer patients. J Clin Oncol 5:641, 1987.
9. Philip PA, Joel S, Monkman SC, et al: A phase I study on the reversal of multidrug resistance (MDR) in vivo: Nifedipine plus etoposide. Br J Cancer 65:267, 1992.
10. Yahanda AM, Adler KM, Fisher GA, et al: Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance. J Clin Oncol 10:1624, 1992.
11. Lette J, Tatum JL, Fraser S, et al. for the Multicenter Dipyridamole Safety Study Investigators: Safety of dipyridamole testing in 73,806 patients: The Multicenter Dipyridamole Safety Study. J Nucl Cardiology 2:3, 1995.
12. Lette J, Carini G, Tatum JL, et al: Safety of Dipyridamole Testing in Patients With Cerebrovascular Disease. Am J Cardiol 75:535, 1995.
13. Howell SB, Sanga R, Vick JS, Hom D: Synergistic potentiation of etoposide, doxorubicin, and vinblastine activity by dipyridamole in sensitive and multiply drug-resistant human cells. Proc Am Soc Clin Oncol 7:56, 1988.
14. Kusumoto H, Maehara Y, Anai H, Kusumoto T, Sugimachi K: Potentiation of adriamycin cytotoxicity by dipyridamole against HeLa cells in vitro and sarcoma 180 cells in vivo. Cancer Res 48:1208, 1988.
15. Dresse A, Chevolet C, Delapierre D, et al: Pharmacokinetics of oral dipyridamole (Persantine) and its effect on platelet adenosine uptake in man. Eur J Clin Pharmacol 23:299, 1982.
16. Fischer PH, Pamukcu R, Bitter G, Willson JK: Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole. Cancer Res 44:3355, 1984.
17. Kolassa N, Pfleger K: Adenosine uptake by erythrocytes of man, rat and guinea-pig and its inhibition by hexobendine and dipyridamole. Biochem Pharmacol 24:154, 1975.
18. Summers A, Subbarao K, Boguslaw R, Niewiarowski S: The effect of dipyridamole on adenosine uptake by platelets ex vivo. Thromb Res 11:611, 1977.
19. Harker LA: Mechanism of action by dipyridamole. Thromb Res 4(Suppl):39, 1983.
20. Luker GD, Fracasso PM, Dobkin J, Piwnica-Worms D: Modulation of the multidrug resistance P-glycoprotein: Detection with technetium-99m sestamibi in vivo. J Nucl Med 38:369, 1997.