Regulation of lateral mobility and cellular trafficking of the CCK receptor by a partial agonist

American Journal of Physiology - Cell Physiology

Volumn 276, Issue 3 45-3, 1999, Pages

  Roettger, Belinda F ^a   Pinon, Delia I ^a   Burghardt, Thomas P ^a   Miller, Laurence J ^a  

^a MAYO CLINIC   (United States)

Author keywords

G protein coupled receptor; Receptor internalization; Receptor mobility

Indexed keywords

CHOLECYSTOKININ RECEPTOR; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; CLATHRIN; PARTIAL AGONIST; PHOSPHOLIPASE C;

ACINAR CELL; ANIMAL CELL; ARTICLE; BINDING COMPETITION; BLEACHING; CALCIUM MOBILIZATION; CELL FUNCTION; CHO CELL; CONTROLLED STUDY; DIFFUSION; DISSOCIATION; DRUG SELECTIVITY; ENDOCYTOSIS; ENZYME ACTIVITY; INTERNALIZATION; LIGAND BINDING; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SOLUBILIZATION; SIGNAL TRANSDUCTION; TEMPERATURE DEPENDENCE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0032950226     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.276.3.c539     Document Type: Article

References (18)

1. Axelrod, D., D. E. Koppel, J. Schlessinger, E. L. Elson, and W. W. Webb. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. Biophys. J. 16: 1055-1069, 1976.
2. Benya, R. V., M. Akeson, J. Mrozinski, R. T. Jensen, and J. F. Battey. Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes. Mol. Pharmacol. 46: 495-501, 1994.
3. Black, J. A personal view of pharmacology. Annu. Rev. Pharmacol. Toxicol. 36: 1-33, 1996.
4. Daukas, G., and S. H. Zigmond. Inhibition of receptor-mediated but not fluid-phase endocytosis in polymorphonuclear leukocytes. J. Cell Biol. 101: 1673-1679, 1985.
5. De Toledo, C. F., B. F. Roettger, C. Morys-Wortmann, W. E. Schmidt, and L. J. Miller. Cellular handling of unoccupied and agonist-stimulated cholecystokinin receptor determined by immunolocalization. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G488-G497, 1997.
6. Gaisano, H. Y., U. G. Klueppelberg, D. I. Pinon, M. A. Pfenning, S. P. Powers, and L. J. Miller. Novel tool for the study of cholecystokinin-stimulated pancreatic enzyme secretion. J. Clin. Invest. 83: 321-325, 1989.
7. Gaisano, H. Y., and L. J. Miller. Complex role of protein kinase C in mediating the supramaximal inhibition of pancreatic secretion observed with cholecystokinin. Biochem. Biophys. Res. Commun. 187: 498-506, 1992.
8. 2+ mobilization in rat pancreatic acini. Pancreas 9: 450-453, 1994.
9. Galas, M. C., M. F. Lignon, M. Rodriguez, C. Mendre, P. Fulcrand, J. Laur, and J. Martinez. Structure-activity relationship studies on cholecystokinin: analogues with partial agonist activity. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G176-G182, 1988.
10. Gates, L. K., C. D. Ulrich, and L. J. Miller. Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G840-G847, 1993.
11. Hadac, E. M., D. V. Ghanekar, E. L. Holicky, D. I. Pinon, R. W. Dougherty, and L. J. Miller. Relationship between native and recombinant cholecystokinin receptors: role of differential glycosylation. Pancreas 13: 130-139, 1996.
12. Heuser, J. E., and R. G. W. Anderson. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J. Cell Biol. 108: 389-400, 1989.
13. Hunyady, L., A. J. Baukal, T. Balla, and K. J. Catt. Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction. J. Biol. Chem. 269: 24798-24804, 1994.
14. Klueppelberg, U. G., L. K. Gates, F. S. Gorelick, and L. J. Miller. Agonist-regulated phosphorylation of the pancreatic cholecystokinin receptor. J. Biol. Chem. 266: 2403-2408, 1991.
15. Lignon, M., M. Galas, M. Rodriquez, G. Gaillon, and J. Martinez. A CCK-analogue that exhibits part of the CCK response on rat pancreatic acini: relationships among amylase release, receptor affinity and phosphoinositide breakdown. In: Gastrin and Cholecystokinin. Chemistry, Physiology, and Pharmacology, edited by J. P. Bali and J. Martinez. New York: Elsevier Science, 1987, p. 57-60.
16. Lignon, M. F., M. C. Galas, M. Rodriguez, and J. Martinez. Correlation between phospholipid breakdown, intracellular calcium mobilization and enzyme secretion in rat pancreatic acini treated with Boc-[Nle28, Nle31]-CCK-7 and JMV180, two cholecystokinin analogues. Cell. Signal. 2: 339-346, 1990.
17. Lutz, M. P., S. L. Sutor, R. T. Abraham, and L. J. Miller. A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. J. Biol. Chem. 268: 11119-11124, 1993.
18. 2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acini. Studies using a new cholecystokinin analog, JMV-180. J. Biol. Chem. 265: 6247-6254, 1990.