Hyperinsulinemia produces cardiac vagal withdrawal and nonuniform sympathetic activation in normal subjects

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 276, Issue 1 45-1, 1999, Pages

  Van De Borne, Philippe ^a,b   Hausberg, Martin ^a   Hoffman, Robert P ^a   Mark, Allyn L ^a   Anderson, Erling A ^a  

^a UNIVERSITY OF IOWA   (United States)

^b ERASME HOSPITAL   (Belgium)

Author keywords

Insulin; Muscle sympathetic nerve activity

Indexed keywords

INSULIN; PROPRANOLOL;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEART; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; MALE; MUSCLE; NEUROGRAPHY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RR INTERVAL; SYMPATHETIC NERVE; VAGUS NERVE; VAGUS TONE;

EID: 0032950061     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.1.r178     Document Type: Article

References (36)

1. Akselrod, S., D. Gordon, F. A. Ubel, D. C. Shannon, A. C. Barger, and R. J. Cohen. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat to beat cardiovascular control. Science 213: 220-222, 1981.
2. Anderson, E. A., T. W. Balon, R. P. Hoffman, C. A. Sinkey, and A. L. Mark. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension 19: 621-627, 1992.
3. Anderson, E. A., R. P. Hoffman, T. W. Balon, C. A. Sinkey, and A. L. Mark. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J. Clin. Invest. 87: 2246-2252, 1991.
4. Anderson, E. A., C. A. Sinkey, W. J. Lawton, and A. L. Mark. Elevated sympathetic nerve activity in borderline hypertensive humans. Hypertension 14: 177-183, 1989.
5. Arone, L. J., R. Mackintosh, M. Rosenbaum, R. L. Leibel, and J. Hirsch. Autonomic nervous system activity in weight gain and weight loss. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R222-R225, 1995.
6. Baron, A. D., and G. Brechtel. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E61-E67, 1993.
7. Bellavere, F., V. Cacciatori, P. Moghetti, M. L. Gemma, A. Dellera, F. Tosi, C. Negri, K. Thomaseth, and M. Muggeo. Acute effect of insulin on autonomic regulation of the cardiovascular system. Diabet. Med. 13: 709-714, 1996.
8. Berne, C., J. Faqius, T. Pollare, and P. Hjemdahl. The sympathetic response to euglycemic hyperinsulinaemia: evidence from microelectrode nerve recordings in healthy subjects. Diabetologia 35: 873-879, 1992.
9. Bunag, R. D., D. Krizsan, and H. Itoh. Diminished cardiovascular responsiveness to vagal stimulation in obese rats. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R842-R848, 1990.
10. Eckberg, D. L. Sympathovagal balance. A critical appraisal. Circulation 96: 3224-3232, 1997.
11. Emdin, M., E. Muscelli, C. Carpeggiani, A. Natali, C. Catalano, S. Camastra, E. Ferrannini, and A. L'Abbate. Effect of insulin on sympatho-vagal balance in lean and obese subjects (Abstract). Eur. Heart J. 18: 111, 1997.
12. Fei, L., D. J. Statters, K. Hnatkova, J. Poloniecki, M. Malik, and A. J. Camm. Change of autonomic influence on the heart immediately before the onset of spontaneous idiopathic ventricular tachycardia. J. Am. Coll. Cardiol. 24: 1515-1522, 1994.
13. Gray, T. S., and J. E. Morley. Neuropeptide Y: anatomical distribution and possible function in mamalian nervous system. Life Sci. 38: 389-401, 1986.
14. Hayano, J., S. Mukai, M. Sakakibara, A. Okada, K. Takata, and T. Fujinami. Effects of respiratory interval on vagal modulation of heart rate. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H33-H40, 1994.
15. Hirsch, J., R. L. Leibel, R. Mackintosh, and A. Aguirre. Heart rate variability as a measure of autonomic function during weight change in humans. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1418-R1423, 1991.
16. Katona, P. G., and F. Jih. Respiratory sinus arrhythmia: noninvasive measure of parasympathetic control. J. Appl. Physiol. 39: 801-805, 1975.
17. Malik, M., and A. J. Camm. Components of heart rate variability-what they really mean and what we really measure. Am. J. Cardiol. 72: 821-822, 1993.
18. Malliani, A., M. Pagani, F. Lombardi, and S. Cerutti. Cardiovascular neural regulation explored in the frequency domain. Circulation 84: 1482-1492, 1991.
19. Mark, A. L., R. G. Victor, G. Nerhed, and B. G. Wallin. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ. Res. 57: 461-469, 1985.
20. Morgan, D. A., T. W. Balon, B. H. Ginsberg, and A. L. Mark. Nonuniform regional sympathetic nerve response to hyperinsulinemia in rats. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R423-R427, 1993.
21. Mulder, L. J. M. Measurement and analysis methods of heart rate and respiration for use in applied environments. Biol. Psychol. 34: 205-236, 1992.
22. Mulder, L. J. M., H. Van Dellen, P. Van der Meulen, and S. B. Opheikens. CARSPAN: a spectral analysis program for cardiovascular time series. In: Proceedings of the Second Workshop on Computers in Psychology, edited by F. J. Maarse, L. J. M. Mulder, J. Sjouw, and A. E. Akkerman. Lisse, The Netherlands: Swets en Zeitlinger, 1987, p. 30-38.
23. Pagani, M., F. Lombardi, S. Guzzetti, O. Rimoldi, R. Furlan, P. Pizzinelli, G. Sandrone, G. Malfatto, S. Dell'Orto, E. Piccaluga, M. Turiel, G. Baselli, S. Cerutti, and A. Malliani. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympathovagal interaction in man and conscious dog. Circ. Res. 59: 178-193, 1986.
24. Patretta, M., D. Bonaduce, E. de Filippo, G. F. Mureddu, L. Scalfi, F. Marciano, V. Bianchi, L. Salemme, G. de Simone, and F. Contaldo. Assessment of cardiac autonomic control by heart period variability in patients with early-onset familial obesity. Eur. J. Clin. Invest. 25: 826-832, 1995.
25. Pomeranz, M., R. J. B. Macaulay, M. A. Caudill, I. Kutz, D. Adam, D. Gordon, K. M. Kilborn, A. C. Barger, D. C. Shannon, R. J. Cohen, and M. Benson. Assessment of autonomic function in humans by heart rate spectral analysis. Am. J. Physiol. 248 (Heart Circ. Physiol. 17): H151-H153, 1985.
26. Rizza, A. R., P. E. Cryer, and J. E. Gerich. Role of glucagon, catecholamines, and growth hormone in human glucose counter-regulation. J. Clin. Invest. 64: 62-71, 1979.
27. Robbe, H. W., L. J. Mulder, H. Ruddel, W. A. Langewitz, J. B. Veldman, and G. Mulder. Assessment of baroreceptor reflex sensitivity by means of spectral analysis. Hypertension 10: 538-543, 1987.
28. Scherrer, U., and C. Sartori. Insulin as a vascular and sympathoexcitatory hormone. Implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 96: 4104-4113, 1997.
29. Steinberg, H. O., G. Brechtel, A. Johnson, N. Fineberg, and A. D. Baron. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. J. Clin. Invest. 94: 1172-1179, 1994.
30. Task Force of the European Society of Cardiology, and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation 93: 1043-1065, 1996.
31. Truett, A. A., A. T. Borne, M. A. Poincot, and D. B. West. Autonomie control of blood pressure and heart rate in obese hypertensive dogs. Am. J. Physiol. 270 (Regulatory Integrative Comp. Physiol. 39): R541-R549, 1996.
32. Van de Borne, P., P. Biston, M. Paiva, H. Nguyen, P. Linkowski, and J. P. Degaute. Cardiorespiratory respiratory transfer during sleep: a study in young men. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H952-H958, 1995.
33. Vaz, M., G. Jennings, A. Turner, H. Cox, G. Lambert, and M. Esler. Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation 96: 3423-3429, 1997.
34. Wallin, G. Intraneural recording and autonomic function in man. In: Autonomic Failure, edited by R. Bannister. London: Oxford Univ. Press, 1983, p. 36-51.
35. Yalow, R. S., and S. A. Berson. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39: 1157-1175, 1960.
36. Yang, T., and M. N. Levy. Sequence of excitation as a factor in sympathetic-parasympathetic interactions in the heart. Circ. Res. 71: 898-905, 1992.