Treatment of experimental osteosarcoma tumors in rat by herpes simplex thymidine kinase gene transfer and ganciclovir

Anticancer Research

Volumn 19, Issue 1 A, 1999, Pages 77-80

  Charissoux, J L ^a   Grossin, L ^b   Leboutet, M J ^a   Rigaud, Michel ^b  

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF LIMOGES   (France)

Author keywords

Ganciclovir; Gene transfer; Herpes simplex; Osteosarcoma cells; Thymidine kinase gene

Indexed keywords

ANTIVIRUS AGENT; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; GENE TRANSFER; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 1; LUNG METASTASIS; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

ANIMALS; ANTIVIRAL AGENTS; GANCICLOVIR; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; LUNG; NEOPLASM TRANSPLANTATION; OSTEOSARCOMA; RATS; RATS, SPRAGUE-DAWLEY; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 0032949872     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Moolten FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase gene: paradigm for a prospective cancer control strategy. Cancer Res 46: 5276-5281, 1986.
2. Anonymous: Human gene marker/therapy clinical protocols. Hum Gene Ther 7: 1621-47, 1996.
3. Fyfe J, Keller P, Furman P, Miller RL, Elion GB: Thymidine kinase from herpes simplex virus phosphorylates the new antiviral coumpound, 9-(2-hydroxyethoxymethyl)guanine. J Biol Chem 253: 8721-8727, 1978.
4. Field AK, Davies M, DeWitt C, Perry HC, Liou R, Germershausen J, Karkas JD, Ashton WT, Johnoston DB, Tolman RL: 9-([2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci USA 80: 4139-4143, 1983.
5. Cheng YC, Grill SP, Dutschman GE, Nakayama K, Bastow KF: Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells. J Biol Chem 258: 12460-12464, 1983.
6. Elion G: The biochemistry and mechanism of action of acyclovir. J Antimicrob Chemother 12: 9-17, 1983 (Suppl B).
7. Oliver S, Bubley G, Crumpacker C: Inhibition of HSV-transformed murine cells by nucleosid analogs 2'-NDG and 2'-nor GMP. Virology 145: 84-93, 1985.
8. Moolten FL, Wells JM, Heyman RA, Evans RM: Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. Hum Gene Ther 1: 125-134, 1990.
9. Caruso M, Panis Y, Gagandeep S, Houssin D, Salzmann J-L, Klatzmann D: Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 90: 7024-7028, 1993.
10. Allouche M, Delbruck HG, Kle,in B, Masse R, Matar A, Morin M, Lafuma J, Jasmin C: Malignant bone tumours induced by a local injection of colloidal radoioactive 144 Cerium in rats as a model for human osteosarcoma. Int J Cancer 26: 777-782, 1980.
11. Klein B, Pals S, Masse R, Lafuma J, Morin M, Binart N, Jasmin JR, Jasmin C: Studies of bone and soft-tissue tumors indued in rats with radioactive Cerium chloride. Int J Cancer 20: 112-119, 1977.
12. Mazabraud A, Gongora R, Gongora G, Perdereau B, Bataini P, Pouillart P, Zucker JM: Interet de l'etude cinetique au 85 Sr pour la classification des sarcomes osteogenes. Sem Hop Paris 58: 1664-1667, 1982.
13. Thiery JP, Perdereau B, Gongora R, et al: Un modele experimental d'ostcosarcome chez le rat: II L'osteosarcome greffable du rat. Sem Hôp Paris 28-29: 1684-1689, 1982.
14. Carlsson G, Gullberg B, Hafstrom L: Estimation of liver tumor volume using differents formulas-An experimental study in rats. J Cancer Res Clin Oncol 105: 589-599, 1983.
15. Danos O, Mulligan RC: Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci 85: 6460-6464, 1988.
16. Kianmanesh AR, Perrin H, Panis Y, Fabre M, Nagy HJ, Houssin D, Klatzmann D: A distant bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor. Hum Gene Therap 8: 1807-1814, 1997.
17. Holmgren L, O'Reilly MS, Folkman J: Dormancy of micrometastase: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1: 149-153, 1995.