Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 1, 1999, Pages 7-12

  Dai Ho, Ginny ^a   Silverman, Lisa ^a   Bercovici, Ana ^a   Puchalski, Chester ^a   Tulshian, Deen ^a   Yan, Xia ^a   Czarniecki, Michael ^a   Green, Michael ^a   Cleven, Renee ^a   Hongtao, Zhang ^a   Fawzi, Ahmad ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; CYCLIC GMP PHOSPHODIESTERASE; GUANINE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR;

ARTICLE; CHEMICAL REACTION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; DRUG EVALUATION, PRECLINICAL; GUANINE; IMIDAZOLES; INHIBITORY CONCENTRATION 50; ISOENZYMES; PHOSPHODIESTERASE INHIBITORS; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032949441     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00681-7     Document Type: Article

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