-
1
-
-
0000763307
-
Phase I trial of farnesyl-transferase inhibitor, R115777, in advanced cancer
-
(abstr. 1848)
-
Zujewski J, Horak ID, Woestenborghs R, Chiao J, Cusack G, Kohler D, et al. Phase I trial of farnesyl-transferase inhibitor, R115777, in advanced cancer. Proc Am Assoc Cancer Res 1998 ; 39 : 270 (abstr. 1848).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 270
-
-
Zujewski, J.1
Horak, I.D.2
Woestenborghs, R.3
Chiao, J.4
Cusack, G.5
Kohler, D.6
-
2
-
-
0000179877
-
R115777, A novel imidazole farnesyl transferase inhibitor (FTI) with potent oral antitumor activity
-
(abstr. 2169)
-
Skrzat S, Angibaud P, Venet M, Sanz G, Bowden C, End D. R115777, a novel imidazole farnesyl transferase inhibitor (FTI) with potent oral antitumor activity. Proc Am Assoc Cancer Res 1998 ; 39 : 317 (abstr. 2169).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 317
-
-
Skrzat, S.1
Angibaud, P.2
Venet, M.3
Sanz, G.4
Bowden, C.5
End, D.6
-
3
-
-
0000489288
-
Synthesis and in vitro structure-activity relationships of imidazolyl-2-quinolinones as farnesyl protein transferase inhibitors (FTI)
-
(abstr. 2171)
-
Venet M, Angibaud P, Sanz G, Poignet H, End D, Bowden C. Synthesis and in vitro structure-activity relationships of imidazolyl-2-quinolinones as farnesyl protein transferase inhibitors (FTI). Proc Am Assoc Cancer Res 1998 ; 39 : 318 (abstr. 2171).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 318
-
-
Venet, M.1
Angibaud, P.2
Sanz, G.3
Poignet, H.4
End, D.5
Bowden, C.6
-
4
-
-
0000537153
-
SCH 66336, An orally bioavailable tricyclic farnesyl protein transferase inhibitor, demonstrates broad and potent in viva antitumor activity
-
(abstr. 1843)
-
Liu M, Lee S, Yaremko B, Chen J, Dell J, Nielsen L, et al. SCH 66336, an orally bioavailable tricyclic farnesyl protein transferase inhibitor, demonstrates broad and potent in viva antitumor activity. Proc Am Assoc Cancer Res 1998 ; 39 : 270 (abstr. 1843).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 270
-
-
Liu, M.1
Lee, S.2
Yaremko, B.3
Chen, J.4
Dell, J.5
Nielsen, L.6
-
5
-
-
0013553224
-
SCH 66336, An orally bioavailable tricyclic farnesyl transferase inhibitor blocks anchorage-independent growth of Ras-transformed fibroblasts and human tumor cell lines
-
(abstr. 2175)
-
Kirschmeier P, Carr D, Gray K, James L, Patton R, McGuirk M, et al. SCH 66336, an orally bioavailable tricyclic farnesyl transferase inhibitor blocks anchorage-independent growth of Ras-transformed fibroblasts and human tumor cell lines. Proc Am Assoc Cancer Res 1998 ; 39 : 318 (abstr. 2175).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 318
-
-
Kirschmeier, P.1
Carr, D.2
Gray, K.3
James, L.4
Patton, R.5
McGuirk, M.6
-
6
-
-
0000544234
-
In vivo evaluation of farnesyltransferase inhibitor, PD 169451 versus a panel of human tumor xenografts
-
(abstr. 1841)
-
Przybranowski SA, Vincent PW, Lathia C, Hollembaek J, Quin J, Shuler KR, et al. In vivo evaluation of farnesyltransferase inhibitor, PD 169451 versus a panel of human tumor xenografts. Proc Am Assoc Cancer Res 1998 ; 39 : 269 (abstr. 1841).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 269
-
-
Przybranowski, S.A.1
Vincent, P.W.2
Lathia, C.3
Hollembaek, J.4
Quin, J.5
Shuler, K.R.6
-
7
-
-
0000763309
-
RPR 130401, A non-peptidomimetic farnesyl transferase inhibitor with in vivo activity
-
(abstr. 1846)
-
Vrignaud P, Bello A, Bissery MC, Jenkins R, Hasnain A, Mailliet P, et al. RPR 130401, a non-peptidomimetic farnesyl transferase inhibitor with in vivo activity. Proc Am Assoc Cancer Res 1998 ; 39 : 560 (abstr. 1846).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 560
-
-
Vrignaud, P.1
Bello, A.2
Bissery, M.C.3
Jenkins, R.4
Hasnain, A.5
Mailliet, P.6
-
8
-
-
0030919869
-
American association for cancer research: Progress and new hope in the fight against cancer
-
Lavelle F. American Association for Cancer Research : progress and new hope in the fight against cancer. Exp Opin Inves Drugs 1997 ; 6 : 771-5.
-
(1997)
Exp Opin Inves Drugs
, vol.6
, pp. 771-775
-
-
Lavelle, F.1
-
9
-
-
0001360235
-
Specific, irreversible inhibitors of the epidermal growth factor receptor (EGFR) family of tyrosine kinases
-
(abstr. 3806)
-
Fry DW, Nelson JM, Slintak V, Keller PR, Loo J, Greis K, et al. Specific, irreversible inhibitors of the epidermal growth factor receptor (EGFR) family of tyrosine kinases. Proc Am Assoc Cancer Res 1998 ; 39 : 560 (abstr. 3806).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 560
-
-
Fry, D.W.1
Nelson, J.M.2
Slintak, V.3
Keller, P.R.4
Loo, J.5
Greis, K.6
-
10
-
-
0001360234
-
Characterization of the in vivo activity of a novel EGF receptor family kinase inhibitor, PD 169414
-
(abstr. 3807)
-
Vincent PW, Akinson BE, Zhou H, Dykes D, Leopold WR, Patmore SJ, et al. Characterization of the in vivo activity of a novel EGF receptor family kinase inhibitor, PD 169414. Proc Am Assoc Cancer Res 1998 ; 39 : 560 (abstr. 3807).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 560
-
-
Vincent, P.W.1
Akinson, B.E.2
Zhou, H.3
Dykes, D.4
Leopold, W.R.5
Patmore, S.J.6
-
11
-
-
0000784536
-
CGP 60474, A protein kinase inhibitor with potent antitumor activity in vivo at well tolerated doses
-
(abstr. 3794)
-
Meyer T, Zimmermann J, Geiger T, Mett H, Buchdunger E, Müller M, et al. CGP 60474, a protein kinase inhibitor with potent antitumor activity in vivo at well tolerated doses. Proc Am Assoc Cancer Res 1998 ; 39 : 558 (abstr. 3794).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 558
-
-
Meyer, T.1
Zimmermann, J.2
Geiger, T.3
Mett, H.4
Buchdunger, E.5
Müller, M.6
-
12
-
-
0013492951
-
Effect of CGP 60474 on cyclin dependent kinases (cdks), cell cycle progression and onset of apoptosis in normal and transformed cells
-
(abstr. 3796)
-
Ruetz St, Woods-Cook K, Solf R, Meyer T, Zimmermann J, Fabbro D. Effect of CGP 60474 on cyclin dependent kinases (cdks), cell cycle progression and onset of apoptosis in normal and transformed cells. Proc Am Assoc Cancer Res 1998 ; 39 : 558 (abstr. 3796).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 558
-
-
Ruetz, St.1
Woods-Cook, K.2
Solf, R.3
Meyer, T.4
Zimmermann, J.5
Fabbro, D.6
-
13
-
-
0000317208
-
The cyclin-dependent kinase inhibitor flavopiridol is an active and unexpectedly toxic agent in advanced gastric cancer
-
(abstr. 896)
-
Werner JL, Kelsen DP, Karpeh M, Inzeo D, Barazzuol J, Sugarman A, et al. The cyclin-dependent kinase inhibitor flavopiridol is an active and unexpectedly toxic agent in advanced gastric cancer. Proc Am Soc Clin Oncol 1998 ; 17 : 234a (abstr. 896).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Werner, J.L.1
Kelsen, D.P.2
Karpeh, M.3
Inzeo, D.4
Barazzuol, J.5
Sugarman, A.6
-
14
-
-
0000100112
-
A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer
-
(abstr. 838)
-
Adams M, Thomas H. A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer. Proc Am Soc Clin Oncol 1998 ; 17 : 217a (abstr. 838).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Adams, M.1
Thomas, H.2
-
15
-
-
0002930613
-
Phase I and pharmacokinetic study of the matrix metalloproteinase inhibitor (MMPI), BAY 12-9566
-
(abstr. 822)
-
Grochow L, O'Reilly S, Humphrey R, Sundaresan P, Donehower R, Satorius S, et al. Phase I and pharmacokinetic study of the matrix metalloproteinase inhibitor (MMPI), BAY 12-9566. Proc Am Soc Clin Oncol 1998 ; 17 : 213a (abstr. 822).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Grochow, L.1
O'Reilly, S.2
Humphrey, R.3
Sundaresan, P.4
Donehower, R.5
Satorius, S.6
-
16
-
-
0013559381
-
The importance of glycosylation and kringle 4 on the activity, of human Angiostatin™ protein
-
(abstr. 311)
-
Liang H, Dey C, Chang A, Lu Y, Zhou X-H, Lapcevich R, et al. The importance of glycosylation and kringle 4 on the activity, of human Angiostatin™ protein. Proc Am Assoc Cancer Res 1998 ; 39 : 46 (abstr. 311).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 46
-
-
Liang, H.1
Dey, C.2
Chang, A.3
Lu, Y.4
Zhou, X.-H.5
Lapcevich, R.6
-
17
-
-
0013559382
-
In vitro and in vivo characterization of CHO expressed human Angiostatin™ kringles 1-3 and kringles 1-4 proteins
-
(abstr. 314)
-
Mac Donald N, Chang A, Zhou X-H, Luu K, Madsen J, Kough E, et al. In vitro and in vivo characterization of CHO expressed human Angiostatin™ kringles 1-3 and kringles 1-4 proteins. Proc Am Assoc Cancer Res 1998 ; 39 : 46 (abstr. 314).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 46
-
-
Mac Donald, N.1
Chang, A.2
Zhou, X.-H.3
Luu, K.4
Madsen, J.5
Kough, E.6
-
18
-
-
0013560389
-
Effect of the Flk-1 antagonist SU5416 on tumor growth, angiogenesis and micro-hemodynamics
-
(abstr. 651)
-
Vajkoczy P, Menger MD, Vollmar B, Schilling L, Schmiedek P, Ullrich A, et al. Effect of the Flk-1 antagonist SU5416 on tumor growth, angiogenesis and micro-hemodynamics. Proc Am Assoc Cancer Res 1998 ; 39 : 96 (abstr. 651).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 96
-
-
Vajkoczy, P.1
Menger, M.D.2
Vollmar, B.3
Schilling, L.4
Schmiedek, P.5
Ullrich, A.6
-
19
-
-
0001360236
-
SU5416: A potent and selective Flk-1/KDR kinase inhibitor that blocks Flk-1 phosphorylation, endothelial cell mitogenesis, and tumor growth
-
(abstr. 3811)
-
Fong TAT, Shawver LK, App H, Sun L, Tang C, Rice A, et al. SU5416 : a potent and selective Flk-1/KDR kinase inhibitor that blocks Flk-1 phosphorylation, endothelial cell mitogenesis, and tumor growth. Proc Am Assoc Cancer Res 1998 ; 39 : 560 (abstr. 3811).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 560
-
-
Fong, T.A.T.1
Shawver, L.K.2
App, H.3
Sun, L.4
Tang, C.5
Rice, A.6
-
20
-
-
0000680988
-
Phase I trial of SU5416, a novel angiogenesis inhibitor in patients with advanced malignancies
-
(abstr. 843)
-
Rosen LS, Kabbinavar F, Rosen P, Mulay M, Quigley S, Hannah AL. Phase I trial of SU5416, a novel angiogenesis inhibitor in patients with advanced malignancies. Proc Am Soc Clin Oncol 1998 ; 17 : 218a (abstr. 843).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Rosen, L.S.1
Kabbinavar, F.2
Rosen, P.3
Mulay, M.4
Quigley, S.5
Hannah, A.L.6
-
21
-
-
0003303170
-
Phase I/pharmacokinetic/pharmacodynamic trial of Raf-1 antisense ODN (ISIS 5132, CGP 69846A)
-
(abstr. 810)
-
O'Dwyer PJ, Stevenson JP, Gallagher M, Mitchell F, Friedland D, Rose L, et al. Phase I/pharmacokinetic/pharmacodynamic trial of Raf-1 antisense ODN (ISIS 5132, CGP 69846A). Proc Am Soc Clin Oncol 1998 ; 17 : 210a (abstr. 810).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
O'Dwyer, P.J.1
Stevenson, J.P.2
Gallagher, M.3
Mitchell, F.4
Friedland, D.5
Rose, L.6
-
22
-
-
0003241331
-
Phase I trial of C-raf antisense oligonucleotide ISIS 5132 (CGP 69846A) by 21-day continuous intravenous infusion (CIV) in patients with advanced cancer
-
(abstr. 811)
-
Holmlund J, Nemunaitis J, Schiller J, Dorr A, Kisner D. Phase I trial of C-raf antisense oligonucleotide ISIS 5132 (CGP 69846A) by 21-day continuous intravenous infusion (CIV) in patients with advanced cancer. Proc Am Soc Clin Oncol 1998 ; 17 : 210a (abstr. 811).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Holmlund, J.1
Nemunaitis, J.2
Schiller, J.3
Dorr, A.4
Kisner, D.5
-
23
-
-
0003139221
-
Phase I/pharmacokinetic (PK) trial of a protein kinase C-A antisense oligonucleotide, ISIS 3521 (CGP 64128A), administered thrice weekly
-
(abstr. 812)
-
Nemunaitis J, Von Hoff DD, Holmlund J, Dorr A, Eckhardt SG. Phase I/pharmacokinetic (PK) trial of a protein kinase C-A antisense oligonucleotide, ISIS 3521 (CGP 64128A), administered thrice weekly. Proc Am Soc Clin Oncol 1998 ; 17 : 211a (abstr. 812).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Nemunaitis, J.1
Von Hoff, D.D.2
Holmlund, J.3
Dorr, A.4
Eckhardt, S.G.5
-
24
-
-
0000905158
-
Efficacy and safety of herceptin™ (humanized anti-HER2 antibody) as a single agent in 222 women with HER2 overexpression who relapsed following chemotherapy for metastatic breast cancer
-
(abstr. 376)
-
Cobleigh MA, Vogel CI, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, et al. Efficacy and safety of herceptin™ (humanized anti-HER2 antibody) as a single agent in 222 women with HER2 overexpression who relapsed following chemotherapy for metastatic breast cancer. Proc Am Soc Clin Oncol 1998 ; 17 : 97a (abstr. 376).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Cobleigh, M.A.1
Vogel, C.I.2
Tripathy, D.3
Robert, N.J.4
Scholl, S.5
Fehrenbacher, L.6
-
25
-
-
0000405942
-
Addition of Herceptin™ (humanized anti-HER2 antibody) to first line chemotherapy for HER2 overexpressing metastatic breast cancer (HER2′/MBC) markedly increases anticancer activity: A randomized, multinational controlled phase III trial
-
(abstr. 377)
-
Slamon D, Leyland-Jones B, Shak S, Paton V, Bajamonde A, Fleming T, et al. Addition of Herceptin™ (humanized anti-HER2 antibody) to first line chemotherapy for HER2 overexpressing metastatic breast cancer (HER2′/MBC) markedly increases anticancer activity : a randomized, multinational controlled phase III trial. Proc Am Soc Clin Oncol 1998 ; 17 : 98a (abstr. 377).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Slamon, D.1
Leyland-Jones, B.2
Shak, S.3
Paton, V.4
Bajamonde, A.5
Fleming, T.6
-
26
-
-
0001123178
-
Phase I trial of recombinant humanized monoclonal anti-vascular endothelial growth factor (anti-VEGF MAB) in patients (pts) with metastatic cancer
-
(abstr. 809)
-
Gordon MS, Talpaz M, Margolin K, Holmgren E, Sledge GW, Benjamin R, et al. Phase I trial of recombinant humanized monoclonal anti-vascular endothelial growth factor (anti-VEGF MAB) in patients (pts) with metastatic cancer. Proc Am Son Clin Oncol 1998 ; 17 : 210a (abstr. 809).
-
(1998)
Proc Am Son Clin Oncol
, vol.17
-
-
Gordon, M.S.1
Talpaz, M.2
Margolin, K.3
Holmgren, E.4
Sledge, G.W.5
Benjamin, R.6
-
27
-
-
0013523499
-
High-field NMR studies of G-quadruplex binding by a telomerase-inhibiting compound
-
(abstr. 2084)
-
Fedorov OY, Salazar M, Kerwin SM, Han H, Hurley LH. High-field NMR studies of G-quadruplex binding by a telomerase-inhibiting compound. Proc Am Assoc Cancer Res 1998 ; 39 : 305 (abstr. 2084).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 305
-
-
Fedorov, O.Y.1
Salazar, M.2
Kerwin, S.M.3
Han, H.4
Hurley, L.H.5
-
28
-
-
0342652613
-
Screening for antitelomerase agents with the aid of Compare analysis
-
(abstr. 3854)
-
Naasani I, Seimiya H, Yamori T, Tsuruo T. Screening for antitelomerase agents with the aid of Compare analysis. Proc Am Assoc Cancer Res 1998 ; 39 : 567 (abstr. 3854).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 567
-
-
Naasani, I.1
Seimiya, H.2
Yamori, T.3
Tsuruo, T.4
-
29
-
-
0006581530
-
A phase I clinical and pharmacokinetic (PK) study of RPR 109881A, a new taxoid administered as a 1-hour infusion in patients (pts) with solid tumors
-
(abstr. 728)
-
Sessa C, Cuvier C, Caldiera S, Vernillet L, Pérard D, Riva A, et al. A phase I clinical and pharmacokinetic (PK) study of RPR 109881A, a new taxoid administered as a 1-hour infusion in patients (pts) with solid tumors. Proc Am Soc Clin Oncol 1998 ; 17 : 189a (abstr. 728).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Sessa, C.1
Cuvier, C.2
Caldiera, S.3
Vernillet, L.4
Pérard, D.5
Riva, A.6
-
31
-
-
0013536862
-
Tubulin polymerization induced by eleutherobin, a novel and potent cytotoxic agent
-
(abstr. 1128)
-
Long BH, Wasserman AJ, Carboni JM, Oh S, Cornell LA, Peterson RW, et al. Tubulin polymerization induced by eleutherobin, a novel and potent cytotoxic agent. Proc Am Assoc Cancer Res 1998 ; 39 : 165 (abstr. 1128).
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 165
-
-
Long, B.H.1
Wasserman, A.J.2
Carboni, J.M.3
Oh, S.4
Cornell, L.A.5
Peterson, R.W.6
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