Synthesis and biological activity of 9-(2,6-difluorobenzyl)-9H-purines bearing chlorine

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 4, 1999, Pages 574-575

  Kozai, Shigetada ^a   Maruyama, Tokumi ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

9 benzylpurine; Mitsunobu reaction; Nucleobase; Phosphodiesterase inhibitor; Phosphodiesterase isozyme

Indexed keywords

2 AMINO 6 CHLORO 9 (2,6 DIFLUOROBENZYL) 9H PURINE; 2 CHLORO 9 (2,6 DIFLUOROBENZYL)ADENINE; 2,6 DICHLORO 9 (2,6 DIFLUOROBENZYL) 9H PURINE DERIVATIVE; 2,6 DICHLOROPURINE; 2,6 DIFLUOROBENZYL ALCOHOL; AMMONIA; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

EID: 0032949185     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.574     Document Type: Article

References (19)

1. Beavo J. A., Physiol. Rev., 75, 725-748 (1995).
2. Bourguignon J.-J., Desaubry L., Raboisson P., Wermuth C.-G., Lugnier C., J. Med. Chem., 40, 1768-1770 (1997).
3. Kelley J. L., Sokoro F. E., J. Med. Chem., 29, 1133-1134 (1986).
4. a) Honjo M., Maruyama T., Horikawa M., Balzarini J., De Clercq E., Chem. Pharm. Bull., 35, 3227-3234 (1987);
5. b) Maruyama T., Sato Y., Oto Y., Takahashi Y., Snoeck R., Andrei G., Witvrouw M., De Clercq E., Chem. Pharm. Bull., 44, 2331-2334 (1996).
6. a) Carson D. A., Wasson D. B., Esparza L. M., Carrera C. J., Kipps T. J., Cottam H. B., Proc. Natl. Acad. Sci. U.S.A., 89, 2970-2974 (1992);
7. b)Secrist J. A. III, Shortnacy A. T., Montgomery J. A., J. Med. Chem., 31, 405-410 (1988);
8. c) Christensen L. F., Broom A. D., J. Med. Chem., 15, 735-739 (1972);
9. d) Angus J. A., Cobbin L. B., Einstein R., Maguire M. H., Br. J. Pharmacol., 41, 592-599 (1971).
10. Kelley J. L., Koble C. S., Davis R. G., McLean E. W., Soroko F. E., Cooper B. R., J. Med. Chem., 38, 4131-4134 (1995).
11. Toyota A., Katagiri N., Kaneko C., Chem. Pharm. Bull., 40, 1039-1041 (1992).
12. Mitsunobu O., Yamada M., Bull. Chem. Soc. Jpn., 40, 2380-2382 (1967).
13. a) Montgomery J. A., Temple, Jr. C., J. Am. Chem. Soc., 83, 630-635 (1961);
14. b) Townsend L. B., Robins R. K., Loeppky R. N., Leonard N. J., J. Am. Chem. Soc., 86, 5320-5325 (1964).
15. Schaeffer H. J., Thomas H. J., J. Am. Chem. Soc., 80, 3738-3742 (1958).
16. Maruyama T., Kozai S., Uchida M., Nucleosides & Nucleotides, in press.
17. Beavo J. A., Reifsnyder D. H., Trends Pharmacol. Sci., 11, 150-155 (1990).
18. Hidaka H., Asano T., Biochim. Biophys. Acta, 429, 485-497 (1976).
19. Nicholson C. D., Chaliss R. A., Shalid M., Trends Pharmacol. Sci., 12, 19-27 (1991).