Comparative effects of dilator drugs on human penile dorsal artery and deep dorsal vein

Clinical Science

Volumn 96, Issue 1, 1999, Pages 59-65

  Segarra, G ^a   Medina, P ^a   Acuna A ^a   Domenech, C ^a   Martinez Leon J B ^a   Vila, J M ^a   Lluch, S ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Constriction; Penile vessels; Relaxation; Sympathetic neurotransmission

Indexed keywords

LINSIDOMINE; NITROPRUSSIDE SODIUM; PAPAVERINE; PROSTAGLANDIN E1; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADOLESCENT; ADULT; AGED; ARTERY DILATATION; ARTICLE; HUMAN; MALE; NORMAL HUMAN; PENIS ARTERY; PENIS VEIN; PRIORITY JOURNAL; VEIN; VEIN DILATATION;

ADOLESCENT; ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HUMANS; IMPOTENCE; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; PENIS; REGRESSION ANALYSIS; SYMPATHETIC NERVOUS SYSTEM; VASODILATOR AGENTS;

EID: 0032949062     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19980207     Document Type: Article

References (37)

1. 1 Krane, R. J., Goldstein, I. and Saenz de Tejada, I. (1989) Impotence. N. Engl. J. Med. 321, 1648-1659
2. 2 Hedlund, P., Holmquist, F., Hedlund, H. and Andersson, K. (1994) Effects of nicorandil on human isolated corpus cavernosum and cavernous artery. J. Urol. 151, 1107-1113
3. 3 Diederichs, W., Stief, C. G., Lue, T. F. and Tanagho, E. A. (1991) Sympathetic inhibition of papaverine induced erection. J. Urol. 146, 195-198
4. 4 Carati, C. J., Creed, K. E. and Keogh, E. J. (1987) Autonomic control of penile erection in the dog. J. Physiol. 384, 525-538
5. 5 Giuliano, F., Bernabe, A., Jardin, A. and Rousseau, J. P. (1993) Antierectile role of the sympathetic nervous system in rats. J. Urol. 150, 519-524
6. 6 Diederichs, W., Stief, C. G., Lue, T. F. and Tanagho, E. A. (1990) Norepinephrine involvement in penile detumescence. J. Urol. 143, 1264-1266
7. 7 Lue, T. F. (1992) Physiology of erection and pathophysiology of impotence. In Campbell's Urology (Walsh, P. C., Gittes, R. F., Perlmutter, A. D. and Stamey, T. A., eds.), pp. 709-728, W. B. Saunders Company, Philadelphia
8. 8 Segarra, G., Medina, P., Domenech, C. et al. (1998) Neurogenic contraction and relaxation of human penile deep dorsal vein. Br. J. Pharmacol. 124, 788-794
9. 9 O'Rourke, M. F. (1982) Arterial Function in Health and Disease, Churchill Livingstone, Edinburgh, London, New York
10. 10 Azadzoi, K. M., Kim, N., Brown, M. L., Goldstein, I., Cohen, R. A. and Saenz de Tejada, I. (1992) Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J. Urol. 147, 220-225
11. 11 Schoeffter, P. and Stoclet, J. (1985) Effects of vasoactive intestinal polypeptide (VIP) on cyclic AMP level and relaxation in rat isolated aorta. Eur. J. Pharmacol. 109, 275-279
12. 12 Molderings, G. J., Gothert, M., Van Ahlen, H. and Porst, H. (1992) Modulation of noradrenaline release in human corpus cavernosum by presynaptic prostaglandin receptors. Int. J. Impotence Res. 4, 19-26
13. 3H]noradrenaline in the rat portal vein. Regul. Pept. 33, 331-337
14. 14 Larsen, J. J., Ottosen, B., Fahrenkrug, J. and Fahrenkrug, G. (1981) Vasoactive intestinal polypeptide (VIP) in the male genito-urinary tract; concentration and motor effect. Invest. Urol. 19, 211-213
15. 15 Hedlund, P., Alm, P., Ekström, P. et al. (1995) Pituitary adenylate cyclase-activating polypeptide, helospectin and vasoactive intestinal polypeptide in human corpus carvernosum. Br. J. Pharmacol. 116, 2258-2266
16. 16 Jünemann, K.-P., Lue, T. F., Luo, J., Jadallah, S. A., Nunes, L. L. and Tanagho, E. A. (1987) The role of vasoactive intestinal polypeptide as a neurotransmitter in penile erection. J. Urol. 138, 871-877
17. 17 Adaikan, P. G., Kottegoda, S. R. and Ratnam, S. S. (1986) Is vasoactive intestinal polypeptide the principal transmitter involved in human penile erection? J. Urol. 135, 638-640
18. 18 Wagner, G. and Gerstenberg, T. (1987) Intracavernous injection of vasoactive intestinal polypeptide (VIP) does not induce erection in man per se. World J. Urol. 5, 171-177
19. 19 Gerstenberg, T. C., Metz, P., Ottesen, B. and Fahrenkrug, J. (1992) Intracavernous self-injection with vasoactive intestinal polypeptide and phentolamine in the management of erectile failure. J. Urol. 147, 1277-1279
20. 20 Virag, R. (1982) Intracavernous injection of papaverine for erectile failure. Lancet ii, 938
21. 21 Rüegg, J. C. (1992) Calcium in muscle contraction. In Cellular and Molecular Physiology, pp. 226-244, Springer-Verlag, Berlin
22. ++ current in isolated smooth muscle cells from the guinea pig trachea. J. Pharmacol. Exp. Ther. 263, 194-200
23. 23 Bülbring, E. and Tomita, T. (1987) Catecholamine action on smooth muscle. Pharmacol. Rev. 39, 49-96
24. 1 in erectile failure: a survey of worldwide experience. J. Urol. 155, 802-815
25. 25 Palmer, R. M. J., Ferrige, A. G. and Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (London) 327, 524-526
26. 26 Moncada, S., Palmer, R. M. J. and Higgs, E. A. (1988) The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension 12, 365-372
27. 27 Moncada, S., Palmer, R. M. J. and Higgs, E. A. (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142
28. 28 Ignarro, L. J., Lippton, H. L., Edwards, J. C. et al. (1981) Mechanisms of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J. Pharmacol. Exp. Ther. 218, 739-749
29. 29 Macarthur, H., Mattammal, M. B. and Westfall, T. C. (1995) A new perspective on the inhibitory role of nitric oxide in sympathetic neurotransmission. Biochem. Biophys. Res. Commun. 216, 686-692
30. 30 Burnett, A. L., Tillman, S. L., Chang, T. S. K. et al. (1993) Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J. Urol. 150, 73-76
31. + - channels. Br. J. Pharmacol. 116, 2582-2590
32. 32 Dail, W. G., Barba, V., Leyba, L. and Galindo, R. (1995) Neural and endothelial nitric oxide synthase activity in rat penile erectile tissue. Cell Tissue Res. 282, 109-116
33. 33 Ignarro, L. J., Bush, P. A., Buga, K. S., Wood, K. S., Fukoto, J. M. and Rajfer, J. (1990) Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun. 170, 843-850
34. 34 Kim, N., Azadzoi, K. M., Goldstein, I. and Saenz de Tejada, I. (1991) A nitric oxide-like factor mediates nonadrenergic - noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J. Clin. Invest. 88, 112-118
35. 35 Stief, C. G., Holmquist, F., Djamilian, M., Krah, H., Andersson, K. E. and Jonas, U. (1992) Preliminary results with the nitric oxide donor linsidomine chlorhydrate in the treatment of human erectile dysfunction. J. Urol. 148, 1437-1440
36. 1 in patients with erectile dysfunction. J. Urol. 153, 1487-1490
37. 37 Andersson, K. and Wagner, G. (1995) Physiology of penile erection. Physiol. Rev. 75, 191-235