Comparison of biological activity and safety of recombinant canine erythropoietin with that of recombinant human erythropoietin in clinically normal dogs

American Journal of Veterinary Research

Volumn 60, Issue 5, 1999, Pages 636-642

  Randolph, John E ^a   Stokol, Tracy ^a   Scarlett, Janet M ^a   MacLeod, James N ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW BIOPSY; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG FORMULATION; DRUG SAFETY; ERYTHROPOIESIS; GENE ISOLATION; HYPOXIA; IMMUNOGENICITY; NONHUMAN; STEM CELL;

EID: 0032948486     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Eschbach JW. The anemia of chronic renal failure: pathophysiology and the effects of recombinant erythropoietin. Kidney Int 1989;35:134-148.
2. Koury ST, Bondurant MC, Koury MJ. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 1988;71:524-527.
3. Krantz SB. Erythropoietin. Blood 1991;77:419-434.
4. Mufson RA, Gesner TG. Binding and internalization of recombinant human erythropoietin in murine erythroid precursor cells. Blood 1987;69:1485-1490.
5. Krantz SB, Goldwasser E. Specific binding of erythropoietin to spleen cells infected with the anemia strain of friend virus. Proc Natl Acad Sci U S A 1984;81:7574-7578.
6. King LG, Giger U, Diserens D, et al. Anemia of chronic renal failure in dogs. J Vet Intern Med 1992;6:264-270.
7. Oishi A, Sakamoto H, Shimizu R. Canine plasma erythropoietin levels in 124 cases of anemia. J Vet Med Sci 1995;57:747-749.
8. Eschbach JW, Kelly MR, Haley NR, et al. Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. N Engl J Med 1989;321:158-163.
9. Eschbach JW, Egrie JC, Downing MR, et al. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 1987;316:73-78.
10. Cowgill LD. Erythropoietin: its use in the treatment of chronic renal failure in dogs and cats, in Proceedings. Annu Waltham/OSU Symp Treat Small Anim Dis 1991;15:65-71.
11. Giger U. Erythropoietin and its clinical use. Compend Contin Educ Pract Vet 1992;14:25-34.
12. Mikiciuk MG, Polzin DJ, Osborne CA. The use of erythropoietin in chronic renal failure. Adv Small Anim Med Surg 1990; 3:1-3.
13. Cowgill LD, James KM, Levy JK, et al. Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure. J Am Vet Med Assoc 1998;212:521-528.
14. Wen D, Boissel JPR, Tracy TE, et al. Erythropoietin structure-function relationship: high degree of sequence homology among mammals. Blood 1993;82:1507-1516.
15. MacLeod JN, Tetreault JW, Lorschy KS, et al. Expression and bioactivity of recombinant canine erythropoietin. Am J Vet Res 1998;59:1144-1148.
16. Cowgill LD. Medical management of the anemia of chronic renal failure. In: Osborne CA, Finco DR, eds. Canine and feline nephrology and urology. Baltimore: The Williams & Wilkins Co, 1995;539-554.
17. Relford RL. The steps in performing a bone marrow aspiration and core biopsy. Vet Med 1991;86:670-688.
18. Dawson-Saunders B, Trapp RG. Basic and clinical biostatistics. Norwalk, Conn: Appleton and Lange, 1994;109-110, 114-116, 134, 152.
19. Goto M, Murakami A, Akai K, et al. Characterization and use of monoclonal antibodies directed against human erythropoietin that recognize different antigenic determinants. Blood 1989;74: 1415-1423.
20. Woods PR, Campbell G, Cowell RL. Nonregenerative anemia associated with administration of recombinant human erythropoietin to a Thoroughbred racehorse. Equine Vet J 1997;29:326-328.
21. Piercy RJ, Swardson CJ, Hinchcliff KW. Erythroid hypoplasia and anemia following administration of recombinant human erythropoietin to two horses. J Am Vet Med Assoc 1997;212:244-247.
22. Bader R, Bode G, Rebel W, et al. Stimulation of bone marrow by administration of excessive doses of recombinant human erythropoietin. Pathol Res Pract 1992;188:676-679.
23. Cowgill LD. Clinical experience and use of recombinant human erythropoietin in uremic dogs and cats, in Proceedings. ACVIM Forum 1991;9:147-149.
24. Jelkmann W. Erythropoietin: structure, control of production, and function. Physiol Rev 1992;72:449-489.
25. Brugnara C, Chambers LA, Malynn E, et al. Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects. Blood 1993;81: 956-964.
26. Brugnara C, Colella GM, Cremins J, et al. Effects of subcutaneous recombinant human erythropoietin in normal subjects: development of decreased reticulocyte hemoglobin content and iron-deficient erythropoiesis. J Lab Clin Med 1994;123:660-667.
27. Biesma DH, Van deWiel A, Beguin Y, et al. Erythropoietic activity and iron metabolism in autologous blood donors during recombinant human erythropoietin therapy. Eur J Clin Invest 1994; 24:426-432.
28. Weiser MG. Erythrocyte responses and disorders. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. 4th ed. Philadelphia: WB Saunders Co, 1995;1864-1891.
29. Skikne BS, Cook JD. Effect of enhanced erythropoiesis on iron absorption. J Lab Clin Med 1992;120:746-751.
30. Goodnough LT, Rudnick S, Price TH, et al. Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy. N Engl J Med 1989;321:1163-1168.
31. Nonnast-Daniel B, Creutzig A, Kuhn K, et al. Effect of treatment with recombinant human erythropoietin on peripheral hemodynamics and oxygenation. Contrib Nephrol 1988;66:185-194.
32. Ellory JC, Tucker EM. Cation transport in red blood cells. In: Agar NS, Board PG, eds. Red blood cells of domestic mammals. Amsterdam: Elserier Scienttific Publishing Co, 1983;291-314.
33. Feldman EC, Nelson RW. Canine and feline endocrinology and reproduction. 2nd ed. Philadelphia: WB Saunders Co, 1996;429.
34. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990;1:43-46.